scholarly journals N-3 and N-6 fatty acids in breast adipose tissue and relative risk of breast cancer in a case-control study in Tours, France

2001 ◽  
Vol 98 (1) ◽  
pp. 78-83 ◽  
Author(s):  
Virginie Maillard ◽  
Philippe Bougnoux ◽  
Pietro Ferrari ◽  
Marie-Lise Jourdan ◽  
Michelle Pinault ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Relative Risk ◽  
Case Control Study ◽  
Case Control ◽  
Breast Adipose Tissue ◽  
Breast Adipose ◽  
Control Study

Omega-3 fatty acids and ERPR(-) and HER2/neu(+/-) breast cancer prevention.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. TPS1589-TPS1589
Author(s):  
Chidimma Kalu ◽  
Sarah Woelke ◽  
Jianying Zhang ◽  
Martha Belury ◽  
Rulong Shen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Corn Oil ◽  
Breast Cancer Subtypes ◽  
Cancer Subtypes ◽  
Her2 Breast Cancer ◽  
Breast Adipose Tissue ◽  
Breast Adipose

TPS1589 Background: The most aggressive breast cancer subtypes tend to be estrogen and progesterone receptor negative (ERPR(-)) and human epidermal growth factor receptor type 2 positive (HER2(+)). Women with these breast cancer subtypes (triple negative, ERPR(-)HER2(+)) tend to experience worse clinical outcomes and have a relatively higher risk of recurrence. Our previous research demonstrated that dietary omega-3 (n-3) fatty acids can significantly inhibit ERPR(-) HER2(+) tumorigenesis in MMTV-HER2/neu transgenic mice fed fish oil vs corn oil-based diets. The fish oil diet group developed 30% fewer breast tumors, had lower Ki67 expression, and experienced less mammary atypia relative to the corn oil diet group. Other studies involving diet, nutrition and breast cancer point to the potentially protective effect of an anti-inflammatory diet on the risk of developing ER(-) and HER2(+) breast cancer, further supporting the evidence that the ERPR(-), HER2(±) subtypes may be highly responsive to this bioactive nutrient. Methods: This is a double-blinded, randomized clinical trial of high dose (~5.4 g EPA+DHA) vs low dose (~0.9 g EPA+DHA in fatty acid mix of the typical American diet) of n-3 fatty acids in breast cancer survivors of ERPR(-), HER2(±) breast cancer. Eligible participants will take 5 capsules/day for 12 months, with cellular samples of breast epithelial and/or adipose tissue obtained by fine needle aspirations of the contralateral breast. The study aims to determine whether n-3 fatty acid supplementation will modify fatty acid metabolite content in breast adipose tissue, modulate cytomorphology and/or cell proliferation in breast epithelial cells, affect DNA methylation patterns, and modulate pro- vs anti-inflammatory gene expression patterns in breast adipose tissue. Correlative aims will evaluate possible associations between factors such as breast adipose tissue, red cell membrane fatty acid profiles, BMI, and reported dietary intake. Sample size of 40 participants per arm was calculated to provide at least 80% power to detect a statistically significant difference for each primary endpoint. This study focuses on women survivors of high risk breast cancer subtypes, specifically triple negative or ERPR(-)HER2(+) disease, who are currently without long term adjuvant options. Eligibility criteria include prior diagnosis of ERPR(-) stage 0 to III breast cancer, ≤5 years from completion of standard therapy.The study was closed to accrual in November 2018; less than 9 months of follow-up remain for active study participants. Clinical trial information: NCT02295059.

scholarly journals Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease

2017 ◽  
Vol 33 (6) ◽  
Author(s):  
Lisiane Lopes Conceição ◽  
Mariana De Moura Dias ◽  
Milene Cristine Pessoa ◽  
Geórgia Das Graças Pena ◽  
Maria Carolina Santos Mendes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Stearic Acid ◽  
Dietary Intake ◽  
Benign Breast Disease ◽  
Breast Disease ◽  
Fatty Acids Composition ◽  
Breast Adipose Tissue ◽  
Breast Adipose

Introduction: Breast cancer is the second most common cancer in the world, and the most frequent cancer among women. Moreover, there are factors that influence the risk for breast cancer including the age, genetic and endocrine factors, and lifestyle.Objectives: Evaluate the consumption of fatty acids; compare the fatty acids composition in the breast adipose tissue of women with breast cancer and benign breast disease as well as potential risk factors; and describe the genotypic frequency of the Pro12Ala PPARγpolymorphism.Material and Methods: A hospital-based case-control study was conducted including incident cases (n = 38 breast cancer; n = 75 benign breast disease; n = 166 control). Lifestyle features, socioeconomic issues, dietary intake, anthropometry, and blood and tissue data were assessed.Results: No differences were observed for fatty acids intake. Interestingly, lauric acid (P = 0.001), myristic acid (P = 0.036), stearic acid (P = 0.031), and total saturated fatty acids (SFAs) (P=0.048) had lower concentrations in BC than in BBD women, while palmitoleic acid (P = 0.022), erucic acid (P = 0.002), total monounsaturated fatty acids (MUFAs) (P = 0.039) and oleic acid/stearic acid ratio (P = 0.015) increased. There was no significant association between PPARγ polymorphism and studied groups (P = 0.977). The age at first full pregnancy (P = 0.004) was significantly associated with the development BC, whereas BMI (P = 0.005); percentage of body fat (P = 0.024); physical activity (P = 0.036); and age at menarche (P = 0.008), at first full pregnancy (P < 0.001), and of first mammogram (P = 0.018) were significantly associated with the development of BBD.Conclusion: The results suggest a different fatty acids composition of breast adipose tissue, a biomarker of long-term dietary intake, particularly for SFAs, MUFA and 18: 1 n-9/18: 00 ratio. Our findings also show that are differences in the factors related to the development of BC and BBC.

Adipose Tissue Trans Fatty Acids and Risk of Coronary Artery Disease: A Case-Control Study

2008 ◽  
Vol 52 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Faranak Ghahremanpour ◽  
Mohsen Firoozrai ◽  
Masoud Darabi ◽  
Abbas Zavarei ◽  
Ahmad Mohebbi
Keyword(s):  
Coronary Artery Disease ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Coronary Artery ◽  
Trans Fatty Acids ◽  
Case Control Study ◽  
Case Control ◽  
Artery Disease ◽  
Control Study

scholarly journals Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China

2007 ◽  
Vol 85 (4) ◽  
pp. 1090-1097 ◽  
Author(s):  
Jackilen Shannon ◽  
Irena B King ◽  
Rachel Moshofsky ◽  
Johanna W Lampe ◽  
Dao Li Gao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Essential fatty acids and breast cancer: A case-control study in Uruguay

1998 ◽  
Vol 76 (4) ◽  
pp. 491-494 ◽  
Author(s):  
Eduardo De Stefani ◽  
Hugo Deneo-Pellegrini ◽  
María Mendilaharsu ◽  
Alvaro Ronco
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Case Control Study ◽  
Essential Fatty Acids ◽  
Case Control ◽  
Control Study
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