scholarly journals Clinical efficacy of fecal microbial transplantation treatment in adults with moderate‐to‐severe atopic dermatitis

2021 ◽  
Author(s):  
Jacob Mashiah ◽  
Tal Karady ◽  
Naomi Fliss‐Isakov ◽  
Eli Sprecher ◽  
Dan Slodownik ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Efficacy ◽  
Severe Atopic Dermatitis

scholarly journals Clinical Efficacy of Blue Light Full Body Irradiation as Treatment Option for Severe Atopic Dermatitis

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e20566 ◽  
Author(s):  
Detlef Becker ◽  
Elise Langer ◽  
Martin Seemann ◽  
Gunda Seemann ◽  
Isabel Fell ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Blue Light ◽  
Treatment Option ◽  
Clinical Efficacy ◽  
Severe Atopic Dermatitis ◽  
Full Body

scholarly journals Early Clinical Efficacy After Dupilumab Therapy for Adult Severe Atopic Dermatitis in a Real-World Setting

2021 ◽  
Vol 147 (2) ◽  
pp. AB28
Author(s):  
Paloma Poza Guedes ◽  
Ruperto Gonzalez Perez ◽  
Elena Mederos Luis ◽  
Victor Matheu ◽  
Cristina Alava ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Efficacy ◽  
Real World ◽  
Severe Atopic Dermatitis ◽  
Real World Setting

scholarly journals Influence of topical immunosuppressive therapy with tacrolimus on local immune response in skin of atopic dermatitis patients

2017 ◽  
Vol 14 (3) ◽  
pp. 27-34
Author(s):  
O G Elisyutina ◽  
E S Fedenko ◽  
M N Boldyreva ◽  
V V Kadochnikova
Keyword(s):  
Gene Expression ◽  
Immune Response ◽  
Atopic Dermatitis ◽  
Clinical Efficacy ◽  
Skin Lesions ◽  
Severe Atopic Dermatitis ◽  
Local Immune Response ◽  
Topical Tacrolimus ◽  
Immune Parameters ◽  
Before And After

Background. To study tacrolimus 0,1% ointment influence on the skin local immune parameters in patients with moderate and severe atopic dermatitis (AD). Materials and methods. The study included 30 patients with moderate (n=20) and severe (n=10) AD. All patients underwent a topical continuous course of treatment with tacrolimus 0,1% ointment twice a day for 14 days. The clinical efficacy of tacrolimus 0,1% ointment was evaluated by the change of the following parameters: SCORAD index, Investigator Global Assessment (IGA) before and after the treatment. All patients underwent a study of local immune response before and after the treatment with the assessment of the expression of IL4, IL5, IL7, IL8, IL10, IL17A, IL23, IL23, IFNγ TGFB1, FOXP3 genes in irritated and treated skin lesions obtained by biopsy. Results. Positive clinical effect - reduction of infiltration, papular rash, dryness, intensity of itch, reflected in the significant decreasing of SCORAD index and IGA was found. The significant decreasing of TGFß (p=0,043308) and IL8 (p=0,038867) gene expression level was revealed, TGFβ and IL8 are the markers of chronic inflammation in atopic dermatitis. The decrease of these parameters during the topical tacrolimus treatment demonstrates local immune response changes in the skin, accompanied by improvement of AD symptoms. Conclusion. The study showed clinical efficacy as well as immunosuppressive activity of tacrolimus 0,1% ointment in patients with moderate and severe AD represented in decreasing of proinflammatory cytokines gene expression TGFβ and IL8 in skin lesions.

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