scholarly journals Eradication of hepatitis C virus infection in kidney transplant recipients using direct‐acting antiviral therapy: Qatar experience

2020 ◽  
Author(s):  
Mohamad M. Alkadi ◽  
Essa A. Abuhelaiqa ◽  
Mostafa F. Elshirbeny ◽  
Ahmed F. Hamdi ◽  
Omar M. Fituri ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Antiviral Therapy ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Hepatitis C Virus Infection ◽  
Kidney Transplant Recipients ◽  
Direct Acting Antiviral ◽  
Direct Acting

Efficacy of Direct-Acting Antiviral Combination Therapy in the Treat-ment of Hepatitis C Virus Among Kidney Transplant Patients

2020 ◽  
Vol 18 ◽  
Author(s):  
Mohammed Al Atbee ◽  
Saad Shaheen Al-Taher ◽  
Majid Alabbood
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Kidney Transplant ◽  
Virological Response ◽  
Hepatitis C Virus Infection ◽  
Direct Acting Antiviral ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
Direct Acting

Background: Up to date, there is no consensus on the best combination of direct-acting antiviral to treat hepatitis C virus in kidney transplant recipients. Objective: This study aims to analyze the efficacy of combination of sofosbuvir and ledipasvir regimen for treatment of hepatitis C virus infected kidney transplant patients. Method: A cross-sectional study conducted in a nephrology clinic and the Nephrology Center in Basrah Teaching Hospital from June 2015 to June 2018. Ledifos (90 mg Ledipasvir and 400 mg Sofosbuvir fixed-dose) was given as a single daily dose for all the participants for 12 weeks. Response for therapy was tested by follow up hepatitis C virus load at the end of 12 weeks and 24 weeks. The sustained virological response was defined as negative viral load of hepatitis C virus (aviremia) at the end of therapy. This study was done according to the Helsinki Congress. Results: A total of 60 (16 females) patients with renal transplantation and hepatitis C virus infection were included. Mean age was 40±6.2 years. A sustained virological response observed in all of the patients who received Ledifos after 12 and 24 weeks of therapy for all genotypes (1a, 1b and 4); p= 0.0001. Genotype 1a was more prevalent among males, 34 (56.6%); p= 0.0001, and it was the most common genotype tested negative serologically, 11 (18.3%). Conclusion: Ledifos therapy is effective and safe option for the treatment of hepatitis C virus infection in the post–renal transplant setting.

Changes in liver function and body composition by direct-acting antiviral therapy for hepatitis C virus infection

2017 ◽  
Vol 48 (5) ◽  
pp. 337-344 ◽  
Author(s):  
Ryosuke Sugimoto ◽  
Motoh Iwasa ◽  
Nagisa Hara ◽  
Yasuyuki Tamai ◽  
Kyoko Yoshikawa ◽  
...  
Keyword(s):  
Body Composition ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Liver Function ◽  
Antiviral Therapy ◽  
Hepatitis C Virus Infection ◽  
Direct Acting Antiviral ◽  
Direct Acting
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