scholarly journals Data mining combined with experiments to validate CEP55 as a prognostic biomarker in colorectal cancer

2020 ◽  
Author(s):  
Kang Lin ◽  
Xiaojian Zhu ◽  
Chen Luo ◽  
Fanqin Bu ◽  
Jinfeng Zhu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Data Mining ◽  
Prognostic Biomarker

scholarly journals Proteomics Identification of Desmin as a Potential Oncofetal Diagnostic and Prognostic Biomarker in Colorectal Cancer

2009 ◽  
Vol 8 (8) ◽  
pp. 1878-1890 ◽  
Author(s):  
Yanlei Ma ◽  
Jiayuan Peng ◽  
Weijie Liu ◽  
Peng Zhang ◽  
Long Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Biomarker

scholarly journals Prokineticin 2 expression as a novel prognostic biomarker for human colorectal cancer

Oncotarget ◽  
2018 ◽  
Vol 9 (53) ◽  
pp. 30079-30091 ◽  
Author(s):  
Yu Yoshida ◽  
Takanori Goi ◽  
Hidetaka Kurebayashi ◽  
Mitsuhiro Morikawa ◽  
Yasuo Hirono ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Biomarker ◽  
Human Colorectal Cancer ◽  
Prokineticin 2

scholarly journals Hsa_circ_0004831 serves as a blood-based prognostic biomarker for colorectal cancer and its potentially circRNA-miRNA-mRNA regulatory network construction

2020 ◽  
Author(s):  
Linlin Xing ◽  
Mengyan Xia ◽  
Xin Jiao ◽  
Ling Fan
Keyword(s):  
Colorectal Cancer ◽  
Extracellular Vesicles ◽  
Regulatory Network ◽  
Prognostic Biomarker ◽  
Qpcr Assay ◽  
Gene Set Enrichment Analysis ◽  
Differentially Expressed ◽  
Expression Level ◽  
Blood Samples ◽  
Tumorigenesis And Progression

Abstract Background: Colorectal cancer (CRC) is a common malignant tumor with unsatisfactory overall prognosis. CircRNAs could be promising prognostic biomarkers in cancers, and play important role in the process of tumorigenesis and progression. Here, we explored the role of hsa_circ_0004831 in blood extracellular vesicles and its prognostic value in CRC. Methods: The circRNA and mRNA expression level matrix in extracellular vesicles of CRC and normal samples were obtained from the exoRBase database. The corresponding miRNA expression level matrix in extracellular vesicles was downloaded from the BBCancer database. Differentially expressed circRNAs, miRNAs and mRNAs were identified using the limma package of R software at the cut-off criteria of fold change (FC) > 2 and adj. p < 0.05. RT-qPCR assay was conducted to measure hsa_circ_0004831 expression level in CRC blood samples. A circRNA-miRNA-mRNA regulatory network of hsa_circ_0004831 was constructed based on competitive endogenous RNA mechanism and differentially expressed genes. The mRNAs co-expressed with hsa_circ_0004831 were screened at the cut-off criteria of pearson |r| > 0.3 and p < 0.05. Gene set enrichment analysis (GSEA) based on co-expressed mRNAs was used to explore the potential molecular function of hsa_circ_0004831. Results: Differentially expressed circRNAs, miRNAs and mRNAs were identified and hsa_circ_0004831 had a FC value of 3.92 in CRC blood extracellular vesicles. The RT-qPCR assay showed that the hsa_circ_0004831 was up-regulated in CRC blood samples. The overall survival analysis found that high expression of hsa_circ_0004831 was linked with poorer prognosis. Finally, a circRNA-miRNA-mRNA regulatory network of hsa_circ_0004831 was constructed based on down-regulated miR-4326 and 12 up-regulated mRNAs. GSEA indicated that mRNAs co-expressed with hsa_circ_0004831 were involved in EMT, WNT and p53 signaling pathways.Conclusions: The study confirmed the up-regulation of hsa_circ_0004831 in CRC, and it may act as a vital prognostic biomarker. The circRNA-miRNA-mRNA regulatory network of hsa_circ_0004831 could be used to uncover the tumorigenesis and progression of CRC.

scholarly journals Data Mining via the Electronic Medical Record to Identify Inherited Colorectal Cancer in an HMO Patient Population

2015 ◽  
Vol 2 (2) ◽  
pp. 82
Author(s):  
Monica Alvarado ◽  
Hilary Kershberg ◽  
George Tiller ◽  
Patty Miller ◽  
Ivan Lizarraga ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Data Mining ◽  
Medical Record ◽  
Electronic Medical Record ◽  
Patient Population

scholarly journals Could gut microbiota serve as prognostic biomarker associated with colorectal cancer patients' survival? A pilot study on relevant mechanism

Oncotarget ◽  
2016 ◽  
Vol 7 (29) ◽  
pp. 46158-46172 ◽  
Author(s):  
Zhiliang Wei ◽  
Shougen Cao ◽  
Shanglong Liu ◽  
Zengwu Yao ◽  
Teng Sun ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Pilot Study ◽  
Gut Microbiota ◽  
Cancer Patients ◽  
Prognostic Biomarker ◽  
Colorectal Cancer Patients

scholarly journals Mitochondrial UQCRB as a new molecular prognostic biomarker of human colorectal cancer

2017 ◽  
Vol 49 (11) ◽  
pp. e391-e391 ◽  
Author(s):  
Hyun-Chul Kim ◽  
Junghwa Chang ◽  
Hannah S Lee ◽  
Ho Jeong Kwon
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Biomarker ◽  
Human Colorectal Cancer

scholarly journals TROY is a promising prognostic biomarker in patients with colorectal cancer

2018 ◽  
Author(s):  
Mitsuaki Nishioka ◽  
Yutaka Suehiro ◽  
Kouhei Sakai ◽  
Toshihiko Matsumoto ◽  
Naoko Okayama ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Biomarker
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