scholarly journals MICA polymorphisms associated with antithyroid drug‐induced agranulocytosis in the Chinese Han population

2020 ◽  
Vol 8 (4) ◽  
pp. 695-703
Author(s):  
Xiaojuan Gong ◽  
Pu Chen ◽  
Pan Ma ◽  
Jiayang Gao ◽  
Jingsi Yang ◽  
...  
Keyword(s):  
Antithyroid Drug ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Drug Induced ◽  
Han Population

Novel Association between Flavin-Containing Monooxygenase 3 Gene Polymorphism and Antithyroid Drug-Induced Agranulocytosis in the Han Population

2019 ◽  
Vol 74 (3) ◽  
pp. 200-206 ◽  
Author(s):  
Ya-Yi He ◽  
Abdulbaqi Mohamed Esmail Hasan ◽  
Qian Zhang ◽  
Shao-Qing Li ◽  
Jing-Si Yang ◽  
...  
Keyword(s):  
Strong Association ◽  
Antithyroid Drug ◽  
Chinese Han Population ◽  
Antithyroid Drugs ◽  
P Value ◽  
Chinese Han ◽  
Drug Induced ◽  
Association Analyses ◽  
Han Population ◽  
Novel Association

Some effective antithyroid drugs (ATDs) have been widely used for patients with Graves’ disease (GD) but are associated with ATD-induced agranulocytosis. We selected 29 ATD-induced agranulocytosis patients, 44 ATD-induced neutropenia patients, and 140 GD controls among the Chinese Han population who were recruited at the First Affiliated Hospital of Xi’an Jiao Tong University. We assessed their response to ATDs treatment by performing genotyping for a candidate gene association study of samples from patients receiving treatment. Human flavin-containing monooxygenase 3 (FMO3), which is the major hepatic enzyme involved in the production of N-oxide of trimethylamine, catalyzes the oxygenation of a variety of drug compounds. Six single SNP, genotype, haplotype (HAP), and association analyses of the FMO3 gene with ATD-induced agranulocytosis/neutropenia under different models (i.e., additive, dominant, and recessive models) were performed. Rs1736557, which caused an amino acid variation V257M, showed a strong association between ATD-induced agranulocytosis and GD controls after Bonferroni correction (p = 0.011, OR 2.301, 95% CI 1.201–4.409). The presence of HAP 3 (HAP3) in the FMO3 gene HAP was statistically associated with ATD-induced agranulocytosis (p = 0.038, permutation p value). Our findings indicate that genetic variations in the FMO3 gene are associated with the response to ATDs maintenance treatment in ATD-induced agranulocytosis patients of ­Chinese Han population.

Relevance of NAT2 genotype to anti‐tuberculosis drug‐induced hepatotoxicity in a Chinese Han population

2019 ◽  
Vol 21 (6) ◽  
Author(s):  
Lihuan Lu ◽  
Bilin Tao ◽  
Haixu Wei ◽  
Hongbo Chen ◽  
Xiaomin He ◽  
...  
Keyword(s):  
Chinese Han Population ◽  
Chinese Han ◽  
Drug Induced ◽  
Han Population ◽  
Nat2 Genotype

CYP2B6 Polymorphisms Are Associated with Ischemic Stroke Risk in a Chinese Han Population

2020 ◽  
Vol 70 (7) ◽  
pp. 1130-1139
Author(s):  
Guolong Tu ◽  
Wenliang Zhan ◽  
Yao Sun ◽  
Jiamin Wu ◽  
Zichao Xiong ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Stroke Risk ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Ischemic Stroke Risk

Association of KIF21B genetic polymorphisms with ankylosing spondylitis in a Chinese Han population of Shandong Province

2014 ◽  
Vol 34 (10) ◽  
pp. 1729-1736 ◽  
Author(s):  
Xinglin Yang ◽  
Ming Li ◽  
Liya Wang ◽  
Zhongdan Hu ◽  
Yuanchao Zhang ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Genetic Polymorphisms ◽  
Shandong Province ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population
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