scholarly journals Disruption in the balance between apolipoprotein A‐I and mast cell chymase in chronic hypersensitivity pneumonitis

2020 ◽  
Vol 8 (4) ◽  
pp. 659-671
Author(s):  
Yukihisa Inoue ◽  
Tsukasa Okamoto ◽  
Takayuki Honda ◽  
Yoshihisa Nukui ◽  
Takumi Akashi ◽  
...  
Keyword(s):  
Mast Cell ◽  
Hypersensitivity Pneumonitis ◽  
Apolipoprotein A ◽  
Chronic Hypersensitivity Pneumonitis ◽  
Mast Cell Chymase

scholarly journals Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties

2016 ◽  
Vol 36 (2) ◽  
pp. 274-284 ◽  
Author(s):  
Su Duy Nguyen ◽  
Katariina Maaninka ◽  
Jani Lappalainen ◽  
Katariina Nurmi ◽  
Jari Metso ◽  
...  
Keyword(s):  
Mast Cell ◽  
Human Mast Cell ◽  
Apolipoprotein A ◽  
Carboxyl Terminal ◽  
Anti Inflammatory ◽  
Mast Cell Chymase

Identification of Chronic Hypersensitivity Pneumonitis Biomarkers with Machine Learning and Differential Co-expression Analysis

2020 ◽  
Vol 20 ◽  
Author(s):  
Hongwei Zhang ◽  
Steven Wang ◽  
Tao Huang
Keyword(s):  
Feature Selection ◽  
Expression Analysis ◽  
Hypersensitivity Pneumonitis ◽  
Enrichment Analysis ◽  
Functional Enrichment ◽  
Great Promise ◽  
Support Vector ◽  
Svm Classifier ◽  
Clinical Tool ◽  
Chronic Hypersensitivity Pneumonitis

Aims: We would like to identify the biomarkers for chronic hypersensitivity pneumonitis (CHP) and facilitate the precise gene therapy of CHP. Background: Chronic hypersensitivity pneumonitis (CHP) is an interstitial lung disease caused by hypersensitive reactions to inhaled antigens. Clinically, the tasks of differentiating between CHP and other interstitial lungs diseases, especially idiopathic pulmonary fibrosis (IPF), were challenging. Objective: In this study, we analyzed the public available gene expression profile of 82 CHP patients, 103 IPF patients, and 103 control samples to identify the CHP biomarkers. Method: The CHP biomarkers were selected with advanced feature selection methods: Monte Carlo Feature Selection (MCFS) and Incremental Feature Selection (IFS). A Support Vector Machine (SVM) classifier was built. Then, we analyzed these CHP biomarkers through functional enrichment analysis and differential co-expression analysis. Result: There were 674 identified CHP biomarkers. The co-expression network of these biomarkers in CHP included more negative regulations and the network structure of CHP was quite different from the network of IPF and control. Conclusion: The SVM classifier may serve as an important clinical tool to address the challenging task of differentiating between CHP and IPF. Many of the biomarker genes on the differential co-expression network showed great promise in revealing the underlying mechanisms of CHP.

scholarly journals Identification of domains in apoA-I susceptible to proteolysis by mast cell chymase: implications for HDL function

2000 ◽  
Vol 41 (6) ◽  
pp. 975-984
Author(s):  
Miriam Lee ◽  
Patrizia Uboldi ◽  
Daniela Giudice ◽  
Alberico L. Catapano ◽  
Petri T. Kovanen
Keyword(s):  
Mast Cell ◽  
Hdl Function ◽  
Mast Cell Chymase

scholarly journals Proteome Analysis of Bronchoalveolar Lavage Fluid in Chronic Hypersensitivity Pneumonitis

2012 ◽  
Vol 61 (1) ◽  
pp. 83-92 ◽  
Author(s):  
Tsukasa Okamoto ◽  
Yasunari Miyazaki ◽  
Ryutaro Shirahama ◽  
Meiyo Tamaoka ◽  
Naohiko Inase
Keyword(s):  
Bronchoalveolar Lavage ◽  
Hypersensitivity Pneumonitis ◽  
Bronchoalveolar Lavage Fluid ◽  
Proteome Analysis ◽  
Lavage Fluid ◽  
Chronic Hypersensitivity Pneumonitis

Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-κB-mediated survival signaling☆

2006 ◽  
Vol 312 (8) ◽  
pp. 1289-1298 ◽  
Author(s):  
M LESKINEN ◽  
H HEIKKILA ◽  
M SPEER ◽  
J HAKALA ◽  
M LAINE ◽  
...  
Keyword(s):  
Mast Cell ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Apoptosis ◽  
Survival Signaling ◽  
Muscle Cell Apoptosis ◽  
Mast Cell Chymase

Mast Cell Hyperplasia in Experimental Hypersensitivity Pneumonitis

1991 ◽  
Vol 96 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Patrick J. Haley ◽  
Mark Schuyler ◽  
Katherine Gott ◽  
Thomas B. Casale
Keyword(s):  
Mast Cell ◽  
Hypersensitivity Pneumonitis ◽  
Cell Hyperplasia ◽  
Mast Cell Hyperplasia
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