scholarly journals Differential susceptibility between skin and vaginal mucosa in sensitization phase of allergic contact dermatitis in mice

2020 ◽  
Vol 8 (4) ◽  
pp. 629-637
Author(s):  
Taku Nishijo ◽  
Kanako Nakayama ◽  
Masaaki Miyazawa ◽  
Yasutaka Kuroda ◽  
Hitoshi Sakaguchi
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Differential Susceptibility ◽  
Vaginal Mucosa ◽  
Sensitization Phase ◽  
Allergic Contact

Participation of Complement 3a receptor (C3aR) in the sensitization phase of Th2 mediated allergic contact dermatitis

2011 ◽  
Vol 21 (1) ◽  
pp. 52-56 ◽  
Author(s):  
Margarete Niebuhr ◽  
Wolfgang Bäumer ◽  
Manfred Kietzmann ◽  
Katja Wichmann ◽  
Annice Heratizadeh ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Sensitization Phase ◽  
Allergic Contact

scholarly journals Selective Elimination of NG2-Expressing Hair Follicle Stem Cells Exacerbates the Sensitization Phase of Contact Dermatitis in a Transgenic Rat Model

2020 ◽  
Vol 21 (18) ◽  
pp. 6922
Author(s):  
Yasuhisa Tamura ◽  
Kumi Takata ◽  
Asami Eguchi ◽  
Yosky Kataoka
Keyword(s):  
Stem Cells ◽  
Immune System ◽  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Hair Cycle ◽  
Anagen Phase ◽  
Hair Follicle Stem Cells ◽  
Sensitization Phase ◽  
Allergic Contact ◽  
Follicle Stem Cells

The hair cycle consists of three different phases: anagen (growth), catagen (regression), and telogen (resting). During the anagen phase, hair follicle stem cells (HFSCs) in the bulge and the secondary hair germ proliferate and generate the outer and inner root sheath cells and the hair shafts. We previously identified NG2-immunoreactive (NG2+) cells as HFSCs in both regions of the hair follicles. Recently, the interaction between the hair cycle and the cutaneous immune system has been re-examined under physiological and pathological conditions. However, the roles of NG2+ HFSCs in the skin’s immune system remain completely elucidated. In the present study, we investigated whether the elimination of NG2+ HFSCs affects the induction of allergic contact dermatitis, using a herpes simplex virus thymidine kinase (HSVtk)/ganciclovir (GCV) suicide gene system. When the GCV solution was applied to the skin of NG2-HSVtk transgenic (Tg) rats during the depilation-induced anagen phase, NG2+ HFSCs in the Tg rat skin induced apoptotic cell death. Under exposure of a hapten, the selective ablation of NG2+ HFSCs during the anagen phase aggravated the sensitization phase of allergic contact dermatitis. These findings suggest that NG2+ HFSCs and their progeny have immunosuppressive abilities during the anagen phase.

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