scholarly journals Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells

2018 ◽  
Vol 6 (2) ◽  
pp. 221-233 ◽  
Author(s):  
Becky Omodho ◽  
Tizong Miao ◽  
Alistair L.J. Symonds ◽  
Randeep Singh ◽  
Suling Li ◽  
...  
Keyword(s):  
T Cells ◽  
Transcription Factors ◽  
Growth Response ◽  
Inflammatory Responses ◽  
Early Growth ◽  
Response Gene ◽  
Early Growth Response ◽  
Early Growth Response Gene

scholarly journals Early Growth Response Gene-2 (Egr-2) Regulates the Development of B and T Cells

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
pp. e18498 ◽  
Author(s):  
Suling Li ◽  
Alistair L. J. Symonds ◽  
Bo Zhu ◽  
Mengya Liu ◽  
Meera V. Raymond ◽  
...  
Keyword(s):  
T Cells ◽  
Growth Response ◽  
Early Growth ◽  
Response Gene ◽  
Early Growth Response ◽  
Early Growth Response Gene

scholarly journals Early Growth Response Gene-2, a Zinc-Finger Transcription Factor, Is Required for Full Induction of Clonal Anergy in CD4+ T Cells

2004 ◽  
Vol 173 (12) ◽  
pp. 7331-7338 ◽  
Author(s):  
John E. Harris ◽  
Kenneth D. Bishop ◽  
Nancy E. Phillips ◽  
John P. Mordes ◽  
Dale L. Greiner ◽  
...  
Keyword(s):  
T Cells ◽  
Transcription Factor ◽  
Zinc Finger ◽  
Growth Response ◽  
Early Growth ◽  
Response Gene ◽  
Zinc Finger Transcription Factor ◽  
Early Growth Response ◽  
Early Growth Response Gene ◽  
Clonal Anergy

scholarly journals Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease

2008 ◽  
Vol 205 (10) ◽  
pp. 2295-2307 ◽  
Author(s):  
Bo Zhu ◽  
Alistair L.J. Symonds ◽  
Joanne E. Martin ◽  
Dimitris Kioussis ◽  
David C. Wraith ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Autoimmune Disease ◽  
Growth Response ◽  
Late Onset ◽  
Early Growth ◽  
Response Gene ◽  
Early Growth Response ◽  
Early Growth Response Gene ◽  
Ifn Γ

Maintaining tolerance of T cells to self-antigens is essential to avoid autoimmune disease. How self-reactive T cells are kept functionally inactive is, however, unknown. In this study, we show that early growth response gene 2 (Egr-2), a zinc-finger transcription factor, is expressed in CD44high T cells and controls their proliferation and activation. In the absence of Egr-2, CD44high, but not CD44low T cells, are hyperreactive and hyperproliferative in vivo. The accumulation of activated CD4+CD44high T cells leads to the development of a late onset lupuslike autoimmune disease characterized by the accumulation of interferon (IFN)-γ and interleukin (IL)-17–producing CD4+ T cells, loss of tolerance to nuclear antigens, massive infiltration of T cells into multiple organs and glomerulonephritis. We found that the expression of cyclin-dependent kinase inhibitor p21cip1 was impaired in Egr-2–deficient T cells, whereas the expression of IFN-γ and IL-17 in response to T cell receptor ligation was significantly increased, suggesting that Egr-2 activates the expression of genes involved in the negative regulation of T cell proliferation and inflammation. These results demonstrate that Egr-2 is an intrinsic regulator of effector T cells and controls the expansion of self-reactive T cells and development of autoimmune disease.

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