Blockade of Cytotoxic T-lymphocyte Antigen-4 by Ipilimumab is Associated with a Profound Long-Lasting Depletion of Foxp3+ Regulatory T Cells: A Mechanistic Explanation for Ipilimumab-Induced Severe Enterocolitis?

2012 ◽  
Vol 18 (8) ◽  
pp. E1598-E1600 ◽  
Author(s):  
S. Nancey ◽  
G. Boschetti ◽  
E. Cotte ◽  
K. Ruel ◽  
T. Almeras ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Mechanistic Explanation ◽  
Lymphocyte Antigen

scholarly journals Ligation of Cytotoxic T Lymphocyte Antigen-4 to T Cell Receptor Inhibits T Cell Activation and Directs Differentiation into Foxp3+Regulatory T Cells

2012 ◽  
Vol 287 (14) ◽  
pp. 11098-11107 ◽  
Author(s):  
Jozsef Karman ◽  
Ji-Lei Jiang ◽  
Nathan Gumlaw ◽  
Hongmei Zhao ◽  
Juanita Campos-Rivera ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
T Cell Receptor ◽  
T Cell Activation ◽  
T Lymphocyte ◽  
Cell Activation ◽  
Cytotoxic T Lymphocyte ◽  
Cell Receptor ◽  
Lymphocyte Antigen

scholarly journals Regulatory T cells control epitope spreading in autoimmune arthritis independent of cytotoxic T-lymphocyte antigen-4

Immunology ◽  
2018 ◽  
Vol 155 (4) ◽  
pp. 446-457 ◽  
Author(s):  
Min Yang ◽  
Katrin Klocke ◽  
Clara Marquina Hernandez ◽  
Bingze Xu ◽  
Inger Gjertsson ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Autoimmune Arthritis ◽  
Epitope Spreading ◽  
Lymphocyte Antigen

Decreased Cytotoxic T-Lymphocyte Antigen 4 Expression on Regulatory T Cells and Th17 Cells in Sarcoidosis: Double Trouble?

2015 ◽  
Vol 192 (6) ◽  
pp. 763-765 ◽  
Author(s):  
Caroline E. Broos ◽  
Menno van Nimwegen ◽  
Johannes C. C. M. in ’t Veen ◽  
Henk C. Hoogsteden ◽  
Rudi W. Hendriks ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
T Lymphocyte ◽  
Th17 Cells ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Antigen

scholarly journals UV irradiation of immunized mice induces type 1 regulatory T cells that suppress tumor antigen specific cytotoxic T lymphocyte responses

2011 ◽  
Vol 129 (5) ◽  
pp. 1126-1136 ◽  
Author(s):  
Masaaki Toda ◽  
Linan Wang ◽  
Suguru Ogura ◽  
Mie Torii ◽  
Makoto Kurachi ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Uv Irradiation ◽  
T Lymphocyte ◽  
Tumor Antigen ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Responses

scholarly journals Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Restricts Clonal Expansion of Helper T Cells

2001 ◽  
Vol 194 (7) ◽  
pp. 893-902 ◽  
Author(s):  
Alden M. Doyle ◽  
Alan C. Mullen ◽  
Alejandro V. Villarino ◽  
Anne S. Hutchins ◽  
Frances A. High ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell Activation ◽  
T Lymphocyte ◽  
Cd4 T Cells ◽  
Cell Activation ◽  
Cytotoxic T Lymphocyte ◽  
Clonal Expansion ◽  
Negative Regulator ◽  
Lymphocyte Antigen ◽  
Cell Divisions

Cytotoxic T lymphocyte antigen (CTLA)-4 plays an essential role in immunologic homeostasis. How this negative regulator of T cell activation executes its functions has remained controversial. We now provide evidence that CTLA-4 mediates a cell-intrinsic counterbalance to restrict the clonal expansion of proliferating CD4+ T cells. The regulation of CTLA-4 expression and function ensures that, after ∼3 cell divisions of expansion, most progeny will succumb to either proliferative arrest or death over the ensuing three cell divisions. The quantitative precision of the counterbalance hinges on the graded, time-independent induction of CTLA-4 expression during the first three cell divisions. In contrast to the limits imposed on unpolarized cells, T helper type 1 (Th1) and Th2 effector progeny may be rescued from proliferative arrest by interleukin (IL)-12 and IL-4 signaling, respectively, allowing appropriately stimulated progeny to proceed to the stage of tissue homing. These results suggest that the cell-autonomous regulation of CTLA-4 induction may be a central checkpoint of clonal expansion of CD4+ T cells, allowing temporally and spatially restricted growth of progeny to be dictated by the nature of the threat posed to the host.

Expression of Cytotoxic T-Lymphocyte Antigen 4 on CD4+ and CD8+ T Cells Is Increased in Acute Lung Injury

2013 ◽  
Vol 32 (12) ◽  
pp. 722-726 ◽  
Author(s):  
Yujia Zhou ◽  
Lunxian Tang ◽  
Minjia Lin ◽  
Shumin Xu ◽  
Jianwen Bai ◽  
...  
Keyword(s):  
T Cells ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
T Lymphocyte ◽  
Cd8 T Cells ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Antigen
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