scholarly journals Tumor necrosis factor-α represses the expression of NHE2 through NF-κB activation in intestinal epithelial cell model, C2BBe1

2011 ◽  
Vol 17 (3) ◽  
pp. 720-731 ◽  
Author(s):  
Ruhul Amin ◽  
Temitope Orenuga ◽  
Sangeeta Tyagi ◽  
Pradeep K. Dudeja ◽  
Krishnamurthy Ramaswamy ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Epithelial Cell ◽  
Tumor Necrosis ◽  
Intestinal Epithelial Cell ◽  
Tumor Necrosis Factor Α ◽  
Cell Model ◽  
Intestinal Epithelial ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Activation of muscarinic cholinoceptor ameliorates tumor necrosis factor-α-induced barrier dysfunction in intestinal epithelial cells

FEBS Letters ◽  
2015 ◽  
Vol 589 (23) ◽  
pp. 3640-3647 ◽  
Author(s):  
Md Rafiqul Islam Khan ◽  
Junsuke Uwada ◽  
Takashi Yazawa ◽  
Md Tariqul Islam ◽  
Susanne M. Krug ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Epithelial Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Barrier Dysfunction ◽  
Factor Α ◽  
Necrosis Factor

Developmentally regulated tumor necrosis factor-α induced nuclear factor-κB activation in intestinal epithelium

2007 ◽  
Vol 292 (5) ◽  
pp. G1411-G1419 ◽  
Author(s):  
Erika C. Claud ◽  
Xiaoqiong Zhang ◽  
Elaine O. Petrof ◽  
Jun Sun
Keyword(s):  
Tumor Necrosis Factor ◽  
Epithelial Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Intestinal Epithelial Cells ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Intestinal Epithelial ◽  
Factor Α ◽  
Necrosis Factor

Premature infants are susceptible to many conditions that are inflammatory in nature. For this patient population, which is expecting the intrauterine environment, pathways necessary for fetal life and development may not have completed the transitions necessary for extrauterine life. In this study, responses to tumor necrosis factor-α were compared in human fetal and adult intestinal epithelial cell lines along with preweaned and postweaned mouse intestinal sections to identify a potential developmental difference that may explain the heightened inflammatory response of preterm infants. The nuclear factor-κB (NF-κB) pathway regulates a wide variety of genes involved in immune and inflammatory processes. We report that, compared with adult intestinal epithelial cells, immature intestinal epithelial cells have increased NF-κB activity associated with increased NF-κB-DNA binding and transcriptional activity. This increased activity appears due to inadequate inhibition of signaling leading to NF-κB activation since there is also increased phosphorylation, ubiquitination, and degradation of the inhibitor of NF-κB in conjunction with decreased baseline expression and delayed resynthesis of this inhibitor. Thus we demonstrate a potential mechanism for the heightened inflammatory response of immature intestinal epithelial cells.

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