Antiglycan antibodies as serological markers in the differential diagnosis of inflammatory bowel disease

2008 ◽  
Vol 14 (5) ◽  
pp. 645-651 ◽  
Author(s):  
Daniele Simondi ◽  
Giulio Mengozzi ◽  
Silvia Betteto ◽  
Renato Bonardi ◽  
Roberta Patrizia Ghignone ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Differential Diagnosis ◽  
Bowel Disease ◽  
Serological Markers ◽  
Inflammatory Bowel ◽  
Antiglycan Antibodies

scholarly journals Rational Use of Fecal Calprotectin in Irritable Bowel Syndrome and Inflammatory Bowel Disease

2021 ◽  
Author(s):  
Roberto Catanzaro ◽  
Alfio Maugeri ◽  
Morena Sciuto ◽  
Fang He ◽  
Baskar Balakrishnan ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Irritable Bowel Syndrome ◽  
Differential Diagnosis ◽  
Bowel Disease ◽  
Intestinal Inflammation ◽  
Gastrointestinal Disorder ◽  
Fecal Calprotectin ◽  
Mean Values ◽  
Inflammatory Bowel ◽  
Irritable Bowel

The gastrointestinal pathologies have increased over the last years. The clinical pictures of inflammatory and irritable bowel disease might overlap, leading to expensive and invasive tests. Our study aims to investigate fecal calprotectin as an effective tool for differential diagnosis of gastrointestinal disorders. Two hundred fifty-six patients with the diagnosis of the gastrointestinal disorder and subjected to colonoscopy were collected for the statistical analysis of fecal calprotectin. The differential diagnosis of intestinal inflammation or non-inflammation was performed according to the Receiver Operating Characteristic (ROC) curve that outlines the Area Under Curve (AUC), Sensitivity (Se), Specificity (Sp). Fecal calprotectin was significantly elevated in patients with inflammatory bowel disease compared with patients with irritable bowel syndrome. Especially, the mean values of fecal calprotectin were 522 g/g (IQR=215-975) and 21 g/g (IQR=14-34.5) in patients with and without inflammation, respectively (P<0.0001). AUC value of fecal calprotectin was 0.958 (Se=88.9%, Sp=91.1%, with a cut-off value of 50 g/g) for differentiating between inflammatory bowel disease and irritable bowel syndrome. Fecal calprotectin seems to be a non-invasive and inexpensive biomarker useful for the purpose of a differential diagnosis between inflammatory bowel disease and irritable bowel syndrome.

scholarly journals Evaluation of novel serological markers and autoantibodies in dogs with inflammatory bowel disease

2020 ◽  
Vol 34 (3) ◽  
pp. 1177-1186 ◽  
Author(s):  
Juan J. Estruch ◽  
Derren Barken ◽  
Nicole Bennett ◽  
Donald K. Krawiec ◽  
Gregory K. Ogilvie ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Serological Markers ◽  
Inflammatory Bowel
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