Expression of nonclassical class I molecules by intestinal epithelial cells

2007 ◽  
Vol 13 (3) ◽  
pp. 298-307 ◽  
Author(s):  
Lilani Perera ◽  
Ling Shao ◽  
Anjlee Patel ◽  
Kelly Evans ◽  
Bertrand Meresse ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Class I ◽  
Intestinal Epithelial ◽  
Nonclassical Class

scholarly journals The Nonclassical Class I Molecule CD1d Associates with the Novel CD8 Ligand gp180 on Intestinal Epithelial Cells

1999 ◽  
Vol 274 (37) ◽  
pp. 26259-26265 ◽  
Author(s):  
Nicola A. Campbell ◽  
Hyun S. Kim ◽  
Richard S. Blumberg ◽  
Lloyd Mayer
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Class I ◽  
Intestinal Epithelial ◽  
The Novel ◽  
Nonclassical Class

Intestinal lumen-derived heat shock protein 110 regulates expression of the MHC-class I-like molecule CD1d on intestinal epithelial cells

2003 ◽  
Vol 124 (4) ◽  
pp. A82-A83 ◽  
Author(s):  
Sean P. Colgan ◽  
Takashi Nagaishi ◽  
Atsushi Mizoguchi ◽  
Emiko Mizoguchi ◽  
Lloyd Mayer ◽  
...  
Keyword(s):  
Heat Shock ◽  
Epithelial Cells ◽  
Heat Shock Protein ◽  
Mhc Class I ◽  
Intestinal Epithelial Cells ◽  
Class I ◽  
Intestinal Lumen ◽  
Intestinal Epithelial

scholarly journals Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells.

1991 ◽  
Vol 174 (1) ◽  
pp. 213-218 ◽  
Author(s):  
M Wu ◽  
L van Kaer ◽  
S Itohara ◽  
S Tonegawa
Keyword(s):  
T Cells ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intraepithelial Lymphocytes ◽  
Class I ◽  
Mouse Strains ◽  
Gamma Delta T Cells ◽  
Intestinal Epithelial ◽  
Gamma Delta ◽  
Activated T Cells

The TL region of the major histocompatibility complex of the mouse contains dozens of tandemly arranged class I genes, including those encoding the thymus leukemia (TL) antigens. TL antigens have been thought to be expressed only on the surface of some T lineage cells, namely immature thymocytes of some mouse strains (TL+ strains), some leukemia cells, and activated T cells. While the function of TL antigens is unknown, recent studies have implicated the products of at least some TL region class I genes as molecules that present antigens to gamma/delta T cells. Since some gamma/delta T cells are known to be specifically associated with certain epithelial tissues, we have investigated the expression of some TL region class I genes in a variety of epithelium-containing tissues. Our results show that the TL antigen gene of C57BL/6 mice, T3b, and the TL antigen genes of BALB/c mice, T3d (previously T3c) and T18d (previously T13c), are highly expressed in the epithelium of the small intestine. In the case of T3b, we further show, using a T3 product-specific antibody, that its product is expressed on the surface of the columnar epithelial cells. In addition, we demonstrated that two other TL region class I genes of C57BL/6 origin, T9b and T21b, are also expressed nearly exclusively in intestinal epithelial cells. These results are consistent with the hypothesis that the products of these TL region class I genes are recognized by gamma/delta T cell receptors of intestinal intraepithelial lymphocytes, a subset of gamma/delta T cells that is localized in the intestinal epithelium and has a restricted V gamma repertoire. Finally, our study indicates that the relative levels of expression of the two homologous TL antigen genes, T3d and T18d, differ widely between the thymus and the intestine.

scholarly journals Intraepithelial lymphocytes coinduce nitric oxide synthase in intestinal epithelial cells

2000 ◽  
Vol 278 (6) ◽  
pp. G886-G894 ◽  
Author(s):  
Rosemary A. Hoffman
Keyword(s):  
Nitric Oxide ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Antigen Expression ◽  
Intraepithelial Lymphocytes ◽  
Class I ◽  
Epithelial Cell Line ◽  
Cell Contact ◽  
Intestinal Epithelial ◽  
Ifn Γ

The study of mucosal immunity has revealed that complex reciprocal interactions occur between intestinal intraepithelial lymphocytes (IEL) and intestinal epithelial cells (IEC). The present study focuses on the induction of inducible nitric oxide (NO) synthase in cocultures of freshly isolated rat IEL and the rat epithelial cell line IEC-18 after the addition of interleukin-1β (IL-1β), tumor necrosis factor-α, or lipopolysaccharide. When IEL and IEC were separated using Transwell chambers, NO synthesis was not induced, indicating that cell-cell contact was required. Culture of IEC-18 with IEL, even in the absence of inflammatory stimuli such as IL-1β, resulted in upregulation of class I and II antigens on IEC-18, due to the interferon-γ (IFN-γ) that is constitutively produced by IEL. Addition of anti-IFN-γ antibody to the NO-producing cocultures resulted in inhibition of NO synthesis as well as the upregulation of class I and II antigen expression. These data indicate that IFN-γ production by IEL conditions IEC for the expression of other components of the inflammatory process.

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