Double-blind study of cyamemazine and diazepam in the alcohol withdrawal syndrome

2005 ◽  
Vol 20 (7) ◽  
pp. 511-519 ◽  
Author(s):  
Jean-Daniel Favre ◽  
Hervé Allain ◽  
Henri-Jean Aubin ◽  
Elisabeth Frija-Orvoen ◽  
Claudine Gillet ◽  
...  
Keyword(s):  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Alcohol Withdrawal Syndrome ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind

scholarly journals Efficacy of transcutaneous electrical acupoint stimulation combined with diazepam for acute alcohol withdrawal syndrome: A double-blind randomized sham-controlled trial

2020 ◽  
Vol 48 (4) ◽  
pp. 030006052091005
Author(s):  
Yun Song ◽  
Xiaobin Xue ◽  
Haibin Han ◽  
Cuiluan Li ◽  
Jia Jian ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Pittsburgh Sleep Quality Index ◽  
Controlled Trial ◽  
Alcohol Withdrawal Syndrome ◽  
Control Group ◽  
Double Blind ◽  
Improve Sleep Quality ◽  
Acupoint Stimulation

Objective To compare the efficacy of transcutaneous electrical acupoint stimulation (TEAS) combined with diazepam against diazepam alone for treatment of acute alcohol withdrawal syndrome (AWS). Methods In this double-blind randomized sham-controlled trial, men with acute AWS were randomly allocated to either a group treated with TEAS combined with diazepam (n = 57) or a control group treated with sham TEAS combined with diazepam (n = 60). Treatment was performed at four acupoints twice a day for 14 days. The Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar), visual analogue scale (VAS), Pittsburgh Sleep Quality Index (PSQI) and modified Epworth Sleepiness Scale (mESS) were used to evaluate treatment efficacy. Results All scores improved significantly in both groups during the trial. CIWA-Ar scores were lower in the TEAS group than in the control group from day 3 until the end of observation. VAS and mESS scores were also lower in the TEAS group than in the control group on day 7. VAS and PSQI scores were lower in the TEAS group on day 14. Conclusion Combining diazepam with TEAS may result in milder AWS symptoms than diazepam alone, improve sleep quality and reduce sleepiness.

Treatment of Acute Alcohol Withdrawal Syndrome with Carbamazepine: A Double-Blind Comparison with Tiapride

1982 ◽  
Vol 10 (3) ◽  
pp. 160-165 ◽  
Author(s):  
R Agricola ◽  
M Mazzarino ◽  
R Urani ◽  
V Gallo ◽  
E Grossi
Keyword(s):  
Visual Analogue Scale ◽  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Analogue Scale ◽  
Clinical Effect ◽  
Delirium Tremens ◽  
Alcohol Withdrawal Syndrome ◽  
Double Blind ◽  
Significant Difference ◽  
Blind Comparison

A double-blind, randomized trial is described which was designed to compare the clinical effect of 600 mg daily of carbamazepine (Tegretol®) and of tiapride (Sereprile®) in hospitalized patients with pre-delirium tremens. Physicians' assessment of patients' progress was made following 2, 4 and 7 days of treatment. Of the sixty patients admitted to the study, five dropped out for various reasons, leaving fifty-five patients who completed the study. Both drugs were effective in the treatment of alcohol withdrawal symptoms; no significant difference was found between the two treatments with respect to total symptoms' score and visual analogue scale assessment. Carbamazepine gave faster relief of symptoms and demonstrated a preferential action on symptoms like fear and hallucinations. No case of delirium tremens was observed in those patients who completed the trial.

Mesoridazine and Chlorpromazine in the Treatment of Alcohol Withdrawal Syndrome

1973 ◽  
Vol 18 (5) ◽  
pp. 385-387
Author(s):  
J.B. Frost
Keyword(s):  
Side Effects ◽  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Alcohol Intoxication ◽  
Alcohol Withdrawal Syndrome ◽  
Acute Alcohol Intoxication ◽  
Double Blind ◽  
Therapeutic Regime ◽  
Significant Difference

Forty patients admitted for the treatment of alcohol withdrawal were placed on either chlorpromazine or mesoridazine on a double-blind basis. No significant difference in rate or degree of improvement between the two groups was noted and both groups showed an improvement which was more marked in the first week of treatment. There were few significant side effects from either drug. Improvement on either therapeutic regime is predictable and both are effective in relieving or lessening agitation, tremulousness, hallucinations and anxiety in patients recovering from acute alcohol intoxication.

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