scholarly journals Influence of eight ABCB1 polymorphisms on antidepressant response in a prospective cohort of treatment‐free Russian patients with moderate or severe depression: An explorative psychopharmacological study with naturalistic design

2021 ◽  
Author(s):  
Lisanne M. Geers ◽  
Taichi Ochi ◽  
Natalya M. Vyalova ◽  
Innokentiy S. Losenkov ◽  
Diana Z. Paderina ◽  
...  
Keyword(s):  
Prospective Cohort ◽  
Severe Depression ◽  
Antidepressant Response

scholarly journals Moderation of antidepressant response by the serotonin transporter gene

2009 ◽  
Vol 195 (1) ◽  
pp. 30-38 ◽  
Author(s):  
Patricia Huezo-Diaz ◽  
Rudolf Uher ◽  
Rebecca Smith ◽  
Marcella Rietschel ◽  
Neven Henigsberg ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Severe Depression ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Antidepressant Response ◽  
Therapeutic Drugs ◽  
Noradrenaline Reuptake ◽  
Antidepressant Effects ◽  
And Gender

BackgroundThere have been conflicting reports on whether the length polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) moderates the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs). We hypothesised that the pharmacogenetic effect of 5-HTTLPR is modulated by gender, age and other variants in the serotonin transporter gene.AimsTo test the hypothesis that the 5-HTTLPR differently influences response to escitalopram (an SSRI) compared with nortriptyline (a noradrenaline reuptake inhibitor).MethodThe 5-HTTLPR and 13 additional markers across the serotonin transporter gene were genotyped in 795 adults with moderate-to-severe depression treated with escitalopram or nortriptyline in the Genome Based Therapeutic Drugs for Depression (GENDEP) project.ResultsThe 5-HTTLPR moderated the response to escitalopram, with long-allele carriers improving more than short-allele homozygotes. A significant three-way interaction between 5-HTTLPR, drug and gender indicated that the effect was concentrated in males treated with escitalopram. The single-nucleotide polymorphism rs2020933 also influenced outcome.ConclusionsThe effect of 5-HTTLPR on antidepressant response is SSRI specific conditional on gender and modulated by another polymorphism at the 5' end of the serotonin transporter gene.

Methylphenidate in a Patient with Depression and Respiratory Insufficiency

2001 ◽  
Vol 31 (4) ◽  
pp. 443-449 ◽  
Author(s):  
Danusa Céspedes Guizzo Ayache ◽  
Renério Fráguas Júnior
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Insufficiency ◽  
Initial Dose ◽  
Respiratory Function ◽  
Severe Depression ◽  
Critically Ill Patient ◽  
Medical Complications ◽  
Case Description ◽  
Antidepressant Response ◽  
Ventilatory Insufficiency

Objective: We report a case of severe depression in an elderly and critically ill patient with multiple medical complications who was treated with a combination of methylphenidate and sertraline. The objective of this report is to outline the usefulness of methylphenidate as an antidepressant in a patient with respiratory insufficiency. Method: Case description. Results: The patient had a positive clinical response with initial mental confusion due to methylphenidate. An initial dose of 2.5 mg/day allowed antidepressant response and improvement of respiratory function permitting the removal of mechanical ventilation. Conclusion: Methylphenidate may be useful for patients with severe medical conditions including ventilatory insufficiency.

Organizational Justice and Health of Employees: Prospective Cohort Study.

2013 ◽  
Author(s):  
Mika Kivimaki ◽  
Marko Elovainio ◽  
Jussi Vahtera ◽  
Marianna Virtanen ◽  
Jane E. Ferrie
Keyword(s):  
Cohort Study ◽  
Organizational Justice ◽  
Prospective Cohort Study ◽  
Prospective Cohort

Cynical distrust increases breast cancer risk: Evidence from a prospective cohort study

2002 ◽  
Author(s):  
A. R. Aro ◽  
H. J. de Koning ◽  
K. Vehkalahti ◽  
P. Absetz ◽  
M. Schreck ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Prospective Cohort Study ◽  
Prospective Cohort

Cognitive Therapy Versus Medications: Acute Treatment of Severe Depression

2004 ◽  
Author(s):  
Robert J. Derubeis ◽  
Jay D. Amsterdam ◽  
John P. O'Reardon ◽  
Paula R. Young
Keyword(s):  
Cognitive Therapy ◽  
Acute Treatment ◽  
Severe Depression

Early Antidepressant Response Bodes Well

2006 ◽  
Vol 36 (13) ◽  
pp. 8-9
Author(s):  
TIMOTHY F. KIRN
Keyword(s):  
Antidepressant Response
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