Renal effects of long‐term lithium therapy, revisited

2021 ◽  
Author(s):  
M. Kâzım Yazıcı ◽  
Elçin Özçelik Eroğlu ◽  
Aygün Ertuğrul ◽  
A. Elif Anıl Yağcıoğlu ◽  
Esen Ağaoğlu ◽  
...  
Keyword(s):  
Lithium Therapy ◽  
Renal Effects

Renal effects of long‐term lithium therapy in the elderly: a cross‐sectional study

2008 ◽  
Vol 23 (7) ◽  
pp. 685-692 ◽  
Author(s):  
Els J. M. van Melick ◽  
Arend E. Meinders ◽  
Tonko O. Hoffman ◽  
Toine C. G. Egberts
Keyword(s):  
The Elderly ◽  
Cross Sectional Study ◽  
Lithium Therapy ◽  
Sectional Study ◽  
Cross Sectional ◽  
Renal Effects

Long-term Effects of Cognitive-Behavioural Therapy and Lithium Therapy on Depression in the Elderly

1995 ◽  
Vol 167 (5) ◽  
pp. 653-658 ◽  
Author(s):  
K. C. M. Wilson ◽  
M. Scott ◽  
M. Abou-Saleh ◽  
R. Burns ◽  
J. R. M. Copeland
Keyword(s):  
Maintenance Therapy ◽  
Cognitive Behavioural Therapy ◽  
Rating Scale ◽  
Behavioural Therapy ◽  
Lithium Therapy ◽  
Controlled Study ◽  
Depression Severity ◽  
Cognitive Behavioural

BackgroundWe examine the effects of cognitive-behavioural therapy (CBT) as an adjuvant to acute physical treatment and lithium maintenance therapy in reducing depression severity over a follow-up year in elderly depressed patients.MethodThe study consists of three phases. During the acute treatment and continuation phase, 17 of 31 patients received CBT as an adjuvant to treatment as usual. During the maintenance phase of 1 year, subjects were entered into a double-blind, placebo-controlled study of low-dose lithium therapy.ResultsReceiving adjuvant CBT significantly reduced patients' scores on the Hamilton Rating Scale for Depression during the follow-up year (repeated measures analyses of variance; P = 0.007). No significant differences were found between lithium and placebo maintenance therapy.ConclusionsCBT can be adapted as an adjuvant therapy in the treatment of severely depressed elderly patients and reduces depression severity during follow-up. The prophylactic failure of long-term lithium therapy may be explained through poor compliance.

Lithium-associated hyperparathyroidism

2020 ◽  
Vol 81 (11) ◽  
pp. 1-9
Author(s):  
Simon Mifsud ◽  
Kyle Cilia ◽  
Emma L Mifsud ◽  
Mark Gruppetta
Keyword(s):  
Glycogen Synthase ◽  
Early Recognition ◽  
Bipolar Disorders ◽  
Lithium Therapy ◽  
Acute Effects ◽  
Recurrent Depression ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Acute And Chronic Effects

Lithium is a mood stabiliser widely used in the treatment and prophylaxis of mania, bipolar disorders and recurrent depression. Treatment with lithium can give rise to various endocrine and metabolic abnormalities, including thyroid dysfunction, nephrogenic diabetes insipidus and hypercalcaemia. Lithium may induce hypercalcaemia through both acute and chronic effects. The initial acute effects are potentially reversible and occur as a result of lithium's action on the calcium-sensing receptor pathway and glycogen synthase kinase 3, giving rise to a biochemical picture similar to that seen in familial hypocalciuric hypercalcaemia. In the long term, chronic lithium therapy leads to permanent changes within the parathyroid glands by either unmasking hyperparathyroidism in patients with a subclinical parathyroid adenoma or possibly by initiating multiglandular hyperparathyroidism. The latter biochemical picture is identical to that of primary hyperparathyroidism. Lithium-associated hyperparathyroidism, especially in patients on chronic lithium therapy, is associated with increased morbidity. Hence, regular monitoring of calcium levels in patients on lithium therapy is of paramount importance as early recognition of lithium-associated hyperparathyroidism can improve outcomes. This review focuses on the definition, pathophysiology, presentation, investigations and management of lithium-associated hyperparathyroidism.

Uranium in Drinking Water: Renal Effects of Long-Term Ingestion by an Aboriginal Community

2009 ◽  
Vol 64 (4) ◽  
pp. 228-241 ◽  
Author(s):  
Maria L. Limson Zamora ◽  
Jan M. Zielinski ◽  
Gerry B. Moodie ◽  
Renato A. F. Falcomer ◽  
Wendy C. Hunt ◽  
...  
Keyword(s):  
Drinking Water ◽  
Aboriginal Community ◽  
Renal Effects

Acute Lithium-Induced Tremor

1983 ◽  
Vol 143 (1) ◽  
pp. 40-41 ◽  
Author(s):  
S. Pullinger ◽  
P. Tyrer
Keyword(s):  
Drug Treatment ◽  
Antipsychotic Drugs ◽  
Signs And Symptoms ◽  
Lithium Therapy ◽  
Physiological Tremor ◽  
Antiparkinsonian Drug ◽  
Extrapyramidal Signs ◽  
Extrapyramidal Effects ◽  
Acute Lithium

It has recently been found that tremor in patients on long-term lithium therapy has a lower frequency than that of normal physiological tremor and is likely to have an extrapyramidal component (Tyrer et al, 1981). Other extrapyramidal signs and symptoms have been found with chronic lithium therapy (Shopsin and Gershon, 1975; Baastrup et al, 1976; Branchey et al, 1976; Asnis et al, 1979). These extrapyramidal effects differ from the pseudoparkinsonism produced by antipsychotic drugs in that they do not respond to antiparkinsonian drug treatment (Schou, 1970; Tyrer et al, 1980).

Renal Effects of Long Term 5-ASA

2008 ◽  
Vol 103 ◽  
pp. S438
Author(s):  
Harshna Patel ◽  
Aiala Brar ◽  
Khursheed Jeejeebhoy
Keyword(s):  
Renal Effects

Long-term exposure to mercury vapours and renal effects in artisanal gold miners in Colombia

2013 ◽  
Vol 2013 (1) ◽  
pp. 4097
Author(s):  
Laura Andrea Rodriguez-Villamizar ◽  
Luz Helena Sanchez-Rodriguez ◽  
Yolanda Vargas-Fiallo ◽  
Oscar Florez-Vargas
Keyword(s):  
Renal Effects ◽  
Gold Miners

A Double-Blind Trial of Long-Term Lithium Therapy in Mental Defectives

1974 ◽  
Vol 124 (578) ◽  
pp. 52-57 ◽  
Author(s):  
Graham J. Naylor ◽  
J. M. Donald ◽  
David Le Poidevin ◽  
Andrew H. Reid
Keyword(s):  
Therapeutic Effect ◽  
Affective Disorders ◽  
Lithium Therapy ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
Mental Defectives

The therapeutic effect of lithium in mania was first described by Cade (1949), but the possibility that lithium could have a prophylactic action in recurrent affective disorders was not suggested until some years later (Hartigan, 1963; Baastrup, 1964). The early studies of the prophylactic action of lithium were open trials, in which both investigator and patient knew that the patient was receiving the drug. More recently, controlled double-blind studies have confirmed these early reports (Melia, 1970; Coppenet al., 1971; Cundallet al., 19712).

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