New psychoactive substances as part of polydrug abuse within opioid maintenance treatment revealed by comprehensive high-resolution mass spectrometric urine drug screening

2016 ◽  
Vol 31 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Pertti Heikman ◽  
Mira Sundström ◽  
Anna Pelander ◽  
Ilkka Ojanperä
Keyword(s):  
High Resolution ◽  
Maintenance Treatment ◽  
Mass Spectrometric ◽  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
Opioid Maintenance Treatment ◽  
Polydrug Abuse ◽  
Urine Drug ◽  
Resolution Mass ◽  
Urine Drug Screening

Screening new psychoactive substances in urban wastewater using high resolution mass spectrometry

2016 ◽  
Vol 408 (16) ◽  
pp. 4297-4309 ◽  
Author(s):  
Iria González-Mariño ◽  
Emma Gracia-Lor ◽  
Renzo Bagnati ◽  
Claudia P. B. Martins ◽  
Ettore Zuccato ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
Urban Wastewater ◽  
High Resolution Mass ◽  
Resolution Mass

scholarly journals New Synthetic Cathinones and Phenylethylamine Derivatives Analysis in Hair: A Review

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6143
Author(s):  
Vittorio Bolcato ◽  
Claudia Carelli ◽  
Alessandra Radogna ◽  
Francesca Freni ◽  
Matteo Moretti ◽  
...  
Keyword(s):  
Drugs Of Abuse ◽  
Mass Spectrometric ◽  
New Psychoactive Substances ◽  
Tandem Mass ◽  
Psychoactive Substances ◽  
New Class ◽  
Synthetic Cathinone ◽  
Tandem Mass Spectrometric ◽  
Emerging Substances ◽  
Resolution Mass

The analysis of psychoactive substances in hair is of great importance for both clinical and forensic toxicologists since it allows one to evaluate past and continuative exposure to xenobiotics. In particular, a new challenge is represented by new psychoactive substances: Among this new class of drugs of abuse, synthetic cathinone and phenethylamine derivatives are often detected in biological samples. Hence, there is a growing need to develop new analytical procedures or improve old ones in order to conduct evaluations of these emerging substances. This study is a systematic review of all the instrumental and experimental data available in the literature. A total of 32 articles were included in the review. Acidic solvents proved to be the most reliable solutions for extraction. Gas chromatography and liquid chromatography coupled to tandem mass spectrometric and high-resolution mass spectrometric systems represent the majority of the involved instrumental techniques. Sensitivity must be maintained at the pg/mg level to detect any occurrences up to occasional consumption. In total, 23 out of 32 articles reported real positive samples. The most frequently detected substance in hair was mephedrone, followed by butylone, methylone, MDPV, and α-pyrrolidinophenone-type substances.

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