scholarly journals ROHMM – A Flexible Hidden Markov Model Framework To Detect Runs of Homozygosity From Genotyping Data

2021 ◽  
Author(s):  
Gökalp Çelik ◽  
Timur Tuncalı
Keyword(s):  
Markov Model ◽  
Hidden Markov Model ◽  
Hidden Markov ◽  
Runs Of Homozygosity ◽  
Model Framework

scholarly journals Bayesian hidden Markov models for delineating the pathology of Alzheimer’s disease

2017 ◽  
Vol 28 (7) ◽  
pp. 2112-2124 ◽  
Author(s):  
Kai Kang ◽  
Jingheng Cai ◽  
Xinyuan Song ◽  
Hongtu Zhu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Markov Model ◽  
Cognitive Decline ◽  
Hidden Markov Model ◽  
Hidden Markov ◽  
Semiparametric Regression ◽  
Model Framework

Alzheimer’s disease is a firmly incurable and progressive disease. The pathology of Alzheimer’s disease usually evolves from cognitive normal, to mild cognitive impairment, to Alzheimer’s disease. The aim of this paper is to develop a Bayesian hidden Markov model to characterize disease pathology, identify hidden states corresponding to the diagnosed stages of cognitive decline, and examine the dynamic changes of potential risk factors associated with the cognitive normal–mild cognitive impairment–Alzheimer’s disease transition. The hidden Markov model framework consists of two major components. The first one is a state-dependent semiparametric regression for delineating the complex associations between clinical outcomes of interest and a set of prognostic biomarkers across neurodegenerative states. The second one is a parametric transition model, while accounting for potential covariate effects on the cross-state transition. The inter-individual and inter-process differences are taken into account via correlated random effects in both components. Based on the Alzheimer’s Disease Neuroimaging Initiative data set, we are able to identify four states of Alzheimer’s disease pathology, corresponding to common diagnosed cognitive decline stages, including cognitive normal, early mild cognitive impairment, late mild cognitive impairment, and Alzheimer’s disease and examine the effects of hippocampus, age, gender, and APOE-[Formula: see text] on degeneration of cognitive function across the four cognitive states.

Hidden Markov model framework for industrial maintenance activities

2014 ◽  
Vol 228 (3) ◽  
pp. 230-242 ◽  
Author(s):  
Bernard Roblès ◽  
Manuel Avila ◽  
Florent Duculty ◽  
Pascal Vrignat ◽  
Stephane Bégot ◽  
...  
Keyword(s):  
Markov Model ◽  
Hidden Markov Model ◽  
Hidden Markov ◽  
Model Framework ◽  
Industrial Maintenance ◽  
Maintenance Activities
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