The enhancer rare germline variation rs548071605 contributes to lung cancer development

2021 ◽  
Author(s):  
Xuchun Wang ◽  
He Cheng ◽  
Yin Yang ◽  
Xianglin Zuo ◽  
Lipei Shao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Development ◽  
Germline Variation

scholarly journals Comprehensive Perspective for Lung Cancer Characterisation Based on AI Solutions Using CT Images

2020 ◽  
Vol 10 (1) ◽  
pp. 118
Author(s):  
Tania Pereira ◽  
Cláudia Freitas ◽  
José Luis Costa ◽  
Joana Morgado ◽  
Francisco Silva ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Targeted Therapies ◽  
Treatment Plan ◽  
Personalised Medicine ◽  
Growth Factor Receptor ◽  
Accurate Diagnosis ◽  
Cancer Development ◽  
Thoracic Computed Tomography ◽  
Plan Selection ◽  
Ct Image Analysis

Lung cancer is still the leading cause of cancer death in the world. For this reason, novel approaches for early and more accurate diagnosis are needed. Computer-aided decision (CAD) can be an interesting option for a noninvasive tumour characterisation based on thoracic computed tomography (CT) image analysis. Until now, radiomics have been focused on tumour features analysis, and have not considered the information on other lung structures that can have relevant features for tumour genotype classification, especially for epidermal growth factor receptor (EGFR), which is the mutation with the most successful targeted therapies. With this perspective paper, we aim to explore a comprehensive analysis of the need to combine the information from tumours with other lung structures for the next generation of CADs, which could create a high impact on targeted therapies and personalised medicine. The forthcoming artificial intelligence (AI)-based approaches for lung cancer assessment should be able to make a holistic analysis, capturing information from pathological processes involved in cancer development. The powerful and interpretable AI models allow us to identify novel biomarkers of cancer development, contributing to new insights about the pathological processes, and making a more accurate diagnosis to help in the treatment plan selection.

scholarly journals Lung cancer development in patients with connective tissue disease–related interstitial lung disease

Medicine ◽  
2016 ◽  
Vol 95 (50) ◽  
pp. e5716 ◽  
Author(s):  
Yasunori Enomoto ◽  
Naoki Inui ◽  
Katsuhiro Yoshimura ◽  
Koji Nishimoto ◽  
Kazutaka Mori ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Connective Tissue ◽  
Lung Disease ◽  
Connective Tissue Disease ◽  
Cancer Development

scholarly journals Differential Impacts of Insulin-Like Growth Factor-Binding Protein-3 (IGFBP-3) in Epithelial IGF-Induced Lung Cancer Development

Endocrinology ◽  
2011 ◽  
Vol 152 (6) ◽  
pp. 2164-2173 ◽  
Author(s):  
Woo-Young Kim ◽  
Mi-Jung Kim ◽  
Hojin Moon ◽  
Ping Yuan ◽  
Jin-Soo Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Tumor ◽  
Binding Protein ◽  
Cancer Development ◽  
Lung Carcinogenesis ◽  
Tobacco Carcinogen ◽  
Igf I ◽  
The Impact ◽  
Igfbp 3

The IGF axis has been implicated in the risk of various cancers. We previously reported a potential role of tissue-derived IGF in lung tumor formation and progression. However, the role of IGF-binding protein (IGFBP)-3, a major IGFBP, on the activity of tissue-driven IGF in lung cancer development is largely unknown. Here, we show that IGF-I, but not IGF-II, protein levels in non-small-cell lung cancer (NSCLC) were significantly higher than those in normal and hyperplastic bronchial epithelium. We found that IGF-I and IGFBP-3 levels in NSCLC tissue specimens were significantly correlated with phosphorylated IGF-IR (pIGF-IR) expression. We investigated the impact of IGFBP-3 expression on the activity of tissue-driven IGF-I in lung cancer development using mice carrying lung-specific human IGF-I transgene (Tg), a germline-null mutation of IGFBP-3, or both. Compared with wild-type (BP3+/+) mice, mice carrying heterozygous (BP3+/−) or homozygous (BP3−/−) deletion of IGFBP-3 alleles exhibited decreases in circulating IGFBP-3 and IGF-I. Unexpectedly, IGFTg mice with 50% of physiological IGFBP-3 (BP3+/−; IGFTg) showed higher levels of pIGF-IR/IR and a greater degree of spontaneous or tobacco carcinogen [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone]-induced lung tumor development and progression than did the IGFTg mice with normal (BP3+/+;IGFTg) or homozygous deletion of IGFBP-3 (BP3−/−; IGFTg). These data show that IGF-I is overexpressed in NSCLC, leading to activation of IGF-IR, and that IGFBP-3, depending on its expression level, either inhibits or potentiates IGF-I actions in lung carcinogenesis.

CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development

Oncogene ◽  
2018 ◽  
Vol 38 (14) ◽  
pp. 2580-2594 ◽  
Author(s):  
Yo-Taro Shirai ◽  
Anna Mizutani ◽  
Saori Nishijima ◽  
Masafumi Horie ◽  
Chisato Kikuguchi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Cancer Development ◽  
Cell Cycle Regulators ◽  
Small Cell Lung ◽  
Negative Cell

Inactivation of SMARCA2 by promoter hypermethylation drives lung cancer development

Gene ◽  
2019 ◽  
Vol 687 ◽  
pp. 193-199 ◽  
Author(s):  
Jixiang Wu ◽  
Keshuai He ◽  
Yajun Zhang ◽  
Jixiang Song ◽  
Zhan Shi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Promoter Hypermethylation ◽  
Cancer Development

scholarly journals Isochorismatase domain-containing protein 1 (ISOC1) participates in DNA damage repair and inflammation-related pathways to promote lung cancer development

2021 ◽  
Vol 10 (3) ◽  
pp. 1444-1456
Author(s):  
Jinghan Shi ◽  
Fujun Yang ◽  
Nanfeng Zhou ◽  
Yan Jiang ◽  
Yanfeng Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Damage ◽  
Dna Damage Repair ◽  
Cancer Development ◽  
Damage Repair

scholarly journals NFATc1 promotes anti-tumoral effector functions and memory CD8+ T cell differentiation during non-small cell lung cancer development

2018 ◽  
pp. canres.3297.2017 ◽  
Author(s):  
Lisanne Heim ◽  
Juliane Friedrich ◽  
Marina Engelhardt ◽  
Denis I Trufa ◽  
Carol I. Geppert ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Differentiation ◽  
T Cell ◽  
Small Cell Lung Cancer ◽  
Cd8 T Cell ◽  
Small Cell ◽  
T Cell Differentiation ◽  
Cancer Development ◽  
Small Cell Lung ◽  
Effector Functions
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