scholarly journals Understanding the Genomic Structure of Copy-Number Variation of the Low-Affinity Fcγ Receptor Region Allows Confirmation of the Association ofFCGR3BDeletion with Rheumatoid Arthritis

2017 ◽  
Vol 38 (4) ◽  
pp. 390-399 ◽  
Author(s):  
Raheleh Rahbari ◽  
Luciana W Zuccherato ◽  
German Tischler ◽  
Belinda Chihota ◽  
Hasret Ozturk ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Copy Number Variation ◽  
Copy Number ◽  
Genomic Structure ◽  
Fcγ Receptor ◽  
Number Variation

Copy Number Variation of the GeneNCF1Is Associated with Rheumatoid Arthritis

2012 ◽  
Vol 16 (1) ◽  
pp. 71-78 ◽  
Author(s):  
Lina M. Olsson ◽  
Annika Nerstedt ◽  
Anna-Karin Lindqvist ◽  
Åsa C.M. Johansson ◽  
Patrik Medstrand ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Copy Number Variation ◽  
Copy Number ◽  
Number Variation

scholarly journals Effect of MPG Gene rs2858056 Polymorphism, Copy Number Variation, and Level of Serum MPG Protein on the Risk for Rheumatoid Arthritis

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0120699 ◽  
Author(s):  
Chung-Ming Huang ◽  
Shih-Yin Chen ◽  
Po-Hao Huang ◽  
Fuu-Jen Tsai
Keyword(s):  
Rheumatoid Arthritis ◽  
Copy Number Variation ◽  
Copy Number ◽  
Number Variation

Contribution of Fc  receptor IIIA gene 158V/F polymorphism and copy number variation to the risk of ACPA-positive rheumatoid arthritis

2008 ◽  
Vol 68 (11) ◽  
pp. 1775-1780 ◽  
Author(s):  
M M Thabet ◽  
T W J Huizinga ◽  
R B Marques ◽  
G Stoeken-Rijsbergen ◽  
A M Bakker ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Copy Number Variation ◽  
Copy Number ◽  
Fc Receptor ◽  
Number Variation

scholarly journals Association of VPREB1 Gene Copy Number Variation and Rheumatoid Arthritis Susceptibility

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Muhammad Muaaz Aslam ◽  
Peter John ◽  
Kang-Hsien Fan ◽  
Attya Bhatti ◽  
Eleanor Feingold ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
B Cells ◽  
Copy Number Variation ◽  
Copy Number ◽  
Gene Copy Number ◽  
Total Sample ◽  
Gene Copy ◽  
Pakistani Population ◽  
Gene Copy Number Variation ◽  
Number Variation

Objective. Copy number variation (CNV) is a structural variation in the human genome that has been associated with multiple clinical phenotypes. B cells are important components of rheumatoid arthritis- (RA-) mediated immune response; hence, CNV in the regulators of B cells (such as VPREB1) can influence RA susceptibility. In this study, we aimed to explore the association of CNV in the VPREB1 gene with RA susceptibility in the Pakistani population. Methods. A total of 1,106 subjects (616 RA cases, 490 healthy controls) were selected from three rheumatology centers in Pakistan. VPREB1 CNV was determined using the TaqMan® CN assay (Hs02879734_cn, Applied Biosystems, Foster City, CA, USA), and CNV was estimated by using CopyCaller® (version 2.1; Applied Biosystems, USA) software. Odds ratio (OR) was calculated by logistic regression with sex and age as covariates in R. Results. A significant association between >2 VPREB1 CNV and RA risk was observed with an OR of 3.92 (95% CI: 1.27 - 12.12; p=0.01746) in the total sample. Whereas <2 CNV showed a significantly protective effect against RA risk in women with an OR of 0.48 (95% CI: 0.29-0.79; p=0.00381). Conclusion. CNV>2 of VPREB1 is a risk factor for RA in the total Pakistani population, while CNV<2 is protective in women.

The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis

2011 ◽  
Vol 48 (11) ◽  
pp. 1338-1343 ◽  
Author(s):  
Seon-Hee Yim ◽  
Yeun-Jun Chung ◽  
Eun-Heui Jin ◽  
Seung-Cheol Shim ◽  
Ji-Young Kim ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Copy Number Variation ◽  
Copy Number ◽  
Potential Role ◽  
Gene Copy Number ◽  
Gene Copy ◽  
Gene Copy Number Variation ◽  
Number Variation

Identification of Novel Germline and Tumor-Specific Nucleotide Variants and Copy Number Variation in Clival Chordomas by Exome Sequencing

2015 ◽  
Vol 76 (S 01) ◽  
Author(s):  
Georgios Zenonos ◽  
Peter Howard ◽  
Maureen Lyons-Weiler ◽  
Wang Eric ◽  
William LaFambroise ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Exome Sequencing ◽  
Copy Number ◽  
Number Variation ◽  
Specific Nucleotide

The impact of paralog genes: detection of copy number variation in spinal muscle atrophy patients

BIOCELL ◽  
2018 ◽  
Vol 42 (3) ◽  
pp. 87-91 ◽  
Author(s):  
Sergio LAURITO ◽  
Juan A. CUETO ◽  
Jimena PEREZ ◽  
Mar韆 ROQU�
Keyword(s):  
Copy Number Variation ◽  
Muscle Atrophy ◽  
Copy Number ◽  
Number Variation ◽  
The Impact
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