MicroRNA Genetic Variation: From Population Analysis to Functional Implications of Three Allele Variants Associated with Cancer

2016 ◽  
Vol 37 (10) ◽  
pp. 1060-1073 ◽  
Author(s):  
Ignasi Torruella-Loran ◽  
Hafid Laayouni ◽  
Begoña Dobon ◽  
Alicia Gallego ◽  
Ingrid Balcells ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Population Analysis ◽  
Functional Implications

Functional implications of genetic variation in human PPARγ

2009 ◽  
Vol 20 (8) ◽  
pp. 380-387 ◽  
Author(s):  
Ellen H. Jeninga ◽  
Mark Gurnell ◽  
Eric Kalkhoven
Keyword(s):  
Genetic Variation ◽  
Functional Implications

The Functional Implications of Common Genetic Variation in CYP3A5 and ABCB1 in Human Proximal Tubule Cells

2015 ◽  
Vol 12 (3) ◽  
pp. 758-768 ◽  
Author(s):  
Noël Knops ◽  
Lambertus P. van den Heuvel ◽  
Rosalinde Masereeuw ◽  
Inge Bongaers ◽  
Henriëtte de Loor ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Proximal Tubule ◽  
Common Genetic Variation ◽  
Proximal Tubule Cells ◽  
Functional Implications ◽  
Tubule Cells ◽  
Human Proximal Tubule

scholarly journals RAPD Profile Analysis of Single and Multigrain Aman Rice (Oryza sativa L.) Varieties Available in Bangladesh

2017 ◽  
Vol 27 (2) ◽  
pp. 195-205
Author(s):  
Shawon Mitra ◽  
Tahmina Islam ◽  
RH Sarker ◽  
M Imdadul Hoque
Keyword(s):  
Genetic Variation ◽  
Molecular Typing ◽  
Rapd Markers ◽  
Profile Analysis ◽  
Oryza Sativa L ◽  
Population Analysis ◽  
Rice Varieties ◽  
Rapd Profile ◽  
Single Grain ◽  
High Level

Genetic variation in 14 local Aman rice varieties of Bangladesh including single grain and multigrain rice was investigated at the DNA level by RAPD molecular typing. Fifteen random primers were initially screened against DNA from five individuals that generated highly reproducible RAPD fragments, which were then subjected to further population analysis. A total 191 RAPD fragments were generated with these primers and 153 (80.1%) were polymorphic, which indicated high level of polymorphism existed within these populations. The size of amplified fragments ranged between 450 and 6000 bp. Pair‐wise distance estimated the range of 0.03 to 0.59 between single and multigrain Aman rice varieties. Results illustrated the potential of RAPD markers to distinguish improved varieties and grain specificity at DNA level.Plant Tissue Cult. & Biotech. 27(2): 195-205, 2017 (December)

Permeability of Endometrial Blood Vessels to Exogenous Horse Radish Peroxidase in Mice. Electron Microscope Study

1973 ◽  
Vol 31 ◽  
pp. 562-563
Author(s):  
M.C. Castillo-Jessen ◽  
A. González-Angulo
Keyword(s):  
Electron Microscopy ◽  
Blood Vessels ◽  
Electron Microscope Study ◽  
Ultrastructural Level ◽  
Low Molecular Weight ◽  
Horse Radish Peroxidase ◽  
Intravascular Injection ◽  
Normal Morphology ◽  
Functional Implications ◽  
Low Molecular Weight Proteins

Information regarding the normal morphology of uterine blood vessels at ultrastructural level in mammals is scarce Electron microscopy studies dealing with endometrial vasculature despite the functional implications due to hormone priming are not available. Light microscopy observations with combined injection of dyes and microradiography along with histochemical studies does not enable us to know the detailed fine structure of the possible various types of blood vessels in this tissue. The present work has been designed to characterize the blood vessels of endometrium of mice as well as the behavior of the endothelium to injection of low molecular weight proteins during the normal estrous cycle in this animal. One hundred and forty female albino mice were sacrificed after intravascular injection of horse radish peroxidase (HRP) at 30 seconds, 5, 15, 30 and 60 minutes.

Automated 3-D cell population analysis in thick tissue sections using laser-scanning confocal-microscopy data

1993 ◽  
Vol 51 ◽  
pp. 562-563
Author(s):  
Hakan Ancin
Keyword(s):  
Laser Scanning ◽  
Population Analysis ◽  
Three Dimensional ◽  
Large Data ◽  
Laser Scanning Confocal Microscopy ◽  
Tissue Slices ◽  
Scanning Confocal Microscopy ◽  
Tissue Sections ◽  
Spatially Adaptive ◽  
Microscopy Data

This paper presents methods for performing detailed quantitative automated three dimensional (3-D) analysis of cell populations in thick tissue sections while preserving the relative 3-D locations of cells. Specifically, the method disambiguates overlapping clusters of cells, and accurately measures the volume, 3-D location, and shape parameters for each cell. Finally, the entire population of cells is analyzed to detect patterns and groupings with respect to various combinations of cell properties. All of the above is accomplished with zero subjective bias.In this method, a laser-scanning confocal light microscope (LSCM) is used to collect optical sections through the entire thickness (100 - 500μm) of fluorescently-labelled tissue slices. The acquired stack of optical slices is first subjected to axial deblurring using the expectation maximization (EM) algorithm. The resulting isotropic 3-D image is segmented using a spatially-adaptive Poisson based image segmentation algorithm with region-dependent smoothing parameters. Extracting the voxels that were labelled as "foreground" into an active voxel data structure results in a large data reduction.

Intraindividual Variability and Stability of Affect and Well-Being

GeroPsych ◽  
2013 ◽  
Vol 26 (3) ◽  
pp. 185-199 ◽  
Author(s):  
Christina Röcke ◽  
Annette Brose
Keyword(s):  
Age Differences ◽  
Well Being ◽  
Subjective Well Being ◽  
Emotional Experiences ◽  
Short Term ◽  
Regulatory Processes ◽  
Functional Implications ◽  
Methodological Approaches ◽  
Underlying Processes

Whereas subjective well-being remains relatively stable across adulthood, emotional experiences show remarkable short-term variability, with younger and older adults differing in both amount and correlates. Repeatedly assessed affect data captures both the dynamics and stability as well as stabilization that may indicate emotion-regulatory processes. The article reviews (1) research approaches to intraindividual affect variability, (2) functional implications of affect variability, and (3) age differences in affect variability. Based on this review, we discuss how the broader literature on emotional aging can be better integrated with theories and concepts of intraindividual affect variability by using appropriate methodological approaches. Finally, we show how a better understanding of affect variability and its underlying processes could contribute to the long-term stabilization of well-being in old age.

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