scholarly journals Putative Prostate Cancer Risk SNP in an Androgen Receptor‐Binding Site of the Melanophilin Gene Illustrates Enrichment of Risk SNPs in Androgen Receptor Target Sites

2015 ◽  
Vol 37 (1) ◽  
pp. 52-64 ◽  
Author(s):  
Huajie Bu ◽  
Narisu Narisu ◽  
Bettina Schlick ◽  
Johannes Rainer ◽  
Thomas Manke ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Binding Site ◽  
Receptor Binding ◽  
Prostate Cancer Risk ◽  
Receptor Binding Site ◽  
Target Sites ◽  
Risk Snps

scholarly journals Association of prostate cancer risk with snps in regions containing androgen receptor binding sites captured by ChIP-On-chip analyses

The Prostate ◽  
2011 ◽  
Vol 72 (4) ◽  
pp. 376-385 ◽  
Author(s):  
Yizhen Lu ◽  
Jielin Sun ◽  
Andrew K. Kader ◽  
Seong-Tae Kim ◽  
Jin-Woo Kim ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Receptor Binding ◽  
Binding Sites ◽  
Prostate Cancer Risk ◽  
On Chip

Polymorphisms in the androgen receptor and the prostate-specific antigen genes and prostate cancer risk

The Prostate ◽  
2005 ◽  
Vol 65 (1) ◽  
pp. 58-65 ◽  
Author(s):  
Claudia A. Salinas ◽  
Melissa A. Austin ◽  
Elaine O. Ostrander ◽  
Janet L. Stanford
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Prostate Cancer Risk

scholarly journals Cag Repeat Number in the Androgen Receptor Gene and Prostate Cancer

2012 ◽  
Vol 15 (1) ◽  
pp. 31-36 ◽  
Author(s):  
S Madjunkova ◽  
A Eftimov ◽  
V Georgiev ◽  
D Petrovski ◽  
A Dimovski ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Receptor Gene ◽  
Prostate Cancer Risk ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Cag Repeats ◽  
Repeat Number

Cag Repeat Number in the Androgen Receptor Gene and Prostate CancerProstate cancer (PC) is the second leading cause of cancer deaths in men. The effects of androgens on prostatic tissue are mediated by the androgen receptor (AR) gene. The 5' end of exon 1 of the AR gene includes a polymorphic CAG triplet repeat that numbers between 10 to 36 in the normal population. The length of the CAG repeats is inversely related to the transactivation function of the AR gene. There is controversy over association between short CAG repeat numbers in the AR gene and PC. This retrospective case-control study evaluates the possible effect of short CAG repeats on the AR gene in prostate cancer risk in Macedonian males. A total of 392 male subjects, 134 PC patients, 106 patients with benign prostatic hyperplasia (BPH) and 152 males from the general Macedonian population were enrolled in this study. The CAG repeat length was determined by fluorescent polymerase chain reaction (PCR) amplification of exon1 of the AR gene followed by capillary electrophoresis (CE) on a genetic analyzer. The mean repeat length in PC patients was 21.5 ±2.65, in controls 22.28 ±2.86 (p = 0.009) and in BPH patients 22.1 ±2.52 (p = 0.038). Short CAG repeats (<19) were found in 21.64% of PC patients vs. 9.43% in BPH patients (p = 0.0154). We also found an association of low Gleason score (<7) with short CAG repeat (<19) in PC patients (p = 0.0306), and no association between the age at diagnosis of PC and BPH and CAG repeat length. These results suggest that reduced CAG repeat length may be associated with increased prostate cancer risk in Macedonian men.

scholarly journals Androgen receptor polymorphisms: Association with prostate cancer risk, relapse and overall survival

1999 ◽  
Vol 84 (5) ◽  
pp. 458-465 ◽  
Author(s):  
Stephen M. Edwards ◽  
Mike D. Badzioch ◽  
Ralph Minter ◽  
Rifat Hamoudi ◽  
Nadine Collins ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Overall Survival ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Prostate Cancer Risk

Abstract 2566: Comprehensive analysis to identify functional basis of prostate cancer risk SNPs

2016 ◽  
Author(s):  
Mridu Middha ◽  
Xing Xu ◽  
Riina-Minna Vaananen ◽  
James Hayes ◽  
Pekka Taimen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Comprehensive Analysis ◽  
Functional Basis ◽  
Risk Snps

scholarly journals GGN repeat length and GGN/CAG haplotype variations in the androgen receptor gene and prostate cancer risk in south Indian men

2006 ◽  
Vol 51 (11) ◽  
pp. 998-1005 ◽  
Author(s):  
Krishnaswamy Vijayalakshmi ◽  
Kumarasamy Thangaraj ◽  
Singh Rajender ◽  
Venkatesan Vettriselvi ◽  
Perumal Venkatesan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Receptor Gene ◽  
Prostate Cancer Risk ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
South Indian ◽  
Indian Men

Androgen Receptor Length Polymorphism Associated with Prostate Cancer Risk in Hispanic Men

2002 ◽  
Vol 168 (5) ◽  
pp. 2245-2248 ◽  
Author(s):  
IVANA BALIC ◽  
STANLEY T. GRAHAM ◽  
DEAN A. TROYER ◽  
BETSY A. HIGGINS ◽  
BRAD H. POLLOCK ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Length Polymorphism ◽  
Prostate Cancer Risk ◽  
Hispanic Men
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