scholarly journals Gender and Cell-Type-Specific Effects of the Transcription-Coupled Repair Protein, ERCC6/CSB, on Repeat Expansion in a Mouse Model of the Fragile X-Related Disorders

2014 ◽  
Vol 35 (3) ◽  
pp. 341-349 ◽  
Author(s):  
Xiao-Nan Zhao ◽  
Karen Usdin
Keyword(s):  
Mouse Model ◽  
Fragile X ◽  
Repeat Expansion ◽  
Cell Type ◽  
Specific Effects ◽  
Repair Protein ◽  
Cell Type Specific ◽  
Transcription Coupled Repair

scholarly journals Cell-Type Specific Channelopathies in the Prefrontal Cortex of the fmr1-/y Mouse Model of Fragile X Syndrome

eNeuro ◽  
2015 ◽  
Vol 2 (6) ◽  
pp. ENEURO.0114-15.2015 ◽  
Author(s):  
Brian E. Kalmbach ◽  
Daniel Johnston ◽  
Darrin H. Brager
Keyword(s):  
Prefrontal Cortex ◽  
Mouse Model ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Cell Type ◽  
Cell Type Specific

scholarly journals Cell Type-Specific mRNA Dysregulation in Hippocampal CA1 Pyramidal Neurons of the Fragile X Syndrome Mouse Model

2017 ◽  
Vol 10 ◽  
Author(s):  
Laura Ceolin ◽  
Nathalie Bouquier ◽  
Jihane Vitre-Boubaker ◽  
Stéphanie Rialle ◽  
Dany Severac ◽  
...  
Keyword(s):  
Mouse Model ◽  
Fragile X Syndrome ◽  
Pyramidal Neurons ◽  
Fragile X ◽  
Cell Type ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1 ◽  
Cell Type Specific ◽  
Specific Mrna

scholarly journals Cell type-specific effects ofYersinia pseudotuberculosisvirulence effectors

2009 ◽  
Vol 11 (12) ◽  
pp. 1750-1767 ◽  
Author(s):  
Anna Fahlgren ◽  
Linda Westermark ◽  
Karen Akopyan ◽  
Maria Fällman
Keyword(s):  
Cell Type ◽  
Specific Effects ◽  
Cell Type Specific

scholarly journals MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective

PLoS Genetics ◽  
2018 ◽  
Vol 14 (10) ◽  
pp. e1007719 ◽  
Author(s):  
Xiaonan Zhao ◽  
Yongwei Zhang ◽  
Kenneth Wilkins ◽  
Winfried Edelmann ◽  
Karen Usdin
Keyword(s):  
Mouse Model ◽  
Fragile X ◽  
Repeat Expansion

scholarly journals Cell type-specific effects of isoflurane on two distinct afferent inputs to cortical layer 1

2020 ◽  
Author(s):  
Caitlin A. Murphy ◽  
Matthew I. Banks
Keyword(s):  
Ex Vivo ◽  
Brain Slices ◽  
Pyramidal Cells ◽  
Cellular Level ◽  
Cortical Layer ◽  
Cell Type ◽  
Specific Effects ◽  
Primary Mouse ◽  
Cell Type Specific ◽  
Synaptic Responses

ABSTRACTBackgroundWhile their behavioral effects are well-characterized, the mechanisms by which anaesthetics induce loss of consciousness are largely unknown. Anaesthetics may disrupt integration and propagation of information in corticothalamic networks. Recent studies have shown that isoflurane diminishes synaptic responses of thalamocortical (TC) and corticocortical (CC) afferents in a pathway-specific manner. However, whether the synaptic effects of isoflurane observed in extracellular recordings persist at the cellular level has yet to be explored.MethodsHere, we activate TC and CC layer 1 inputs in non-primary mouse neocortex in ex vivo brain slices and explore the degree to which isoflurane modulates synaptic responses in pyramidal cells and in two inhibitory cell populations, somatostatin-positive (SOM+) and parvalbumin-positive (PV+) interneurons.ResultsWe show that the effects of isoflurane on synaptic responses and intrinsic properties of these cells varies among cell type and by cortical layer. Layer 1 inputs to L4 pyramidal cells were suppressed by isoflurane at both TC and CC synapses, while those to L2/3 pyramidal cells and PV+ interneurons were not. TC inputs to SOM+ cells were rarely observed at all, while CC inputs to SOM+ interneurons were robustly suppressed by isoflurane.ConclusionsThese results suggest a mechanism by which isoflurane disrupts integration and propagation of thalamocortical and intracortical signals.

Cell type-specific effects of BDNF in modulating dendritic architecture of hippocampal neurons

2018 ◽  
Vol 223 (8) ◽  
pp. 3689-3709 ◽  
Author(s):  
Marta Zagrebelsky ◽  
N. Gödecke ◽  
A. Remus ◽  
Martin Korte
Keyword(s):  
Hippocampal Neurons ◽  
Cell Type ◽  
Specific Effects ◽  
Cell Type Specific

scholarly journals Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer’s Disease

2019 ◽  
Vol 13 ◽  
Author(s):  
Corinna Höfling ◽  
Emira Shehabi ◽  
Peer-Hendrik Kuhn ◽  
Stefan F. Lichtenthaler ◽  
Maike Hartlage-Rübsamen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgene Expression ◽  
Tg2576 Mouse ◽  
Cell Type ◽  
Model Of Alzheimer’S Disease ◽  
Cell Type Specific
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