scholarly journals Digenic inheritance of mutations in FOXC1 and PITX2 : Correlating transcription factor function and axenfeld-rieger disease severity

2011 ◽  
Vol 32 (10) ◽  
pp. 1144-1152 ◽  
Author(s):  
Daniel Kelberman ◽  
Lily Islam ◽  
Susan E. Holder ◽  
Thomas S. Jacques ◽  
Patrick Calvas ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Disease Severity ◽  
Digenic Inheritance ◽  
Factor Function

Soluble polyQ protein impairs transcription factor function in a yeast model system

2005 ◽  
Vol 2005 (Spring) ◽  
Author(s):  
Christian Behrends ◽  
Gregor Schaffar ◽  
Peter Breuer ◽  
Raina Boteva ◽  
Nikolay Tzvetkov ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Model System ◽  
Polyq Protein ◽  
Factor Function ◽  
Yeast Model

scholarly journals Mechanistic duality of transcription factor function in phytochrome signaling

2008 ◽  
Vol 105 (6) ◽  
pp. 2232-2237 ◽  
Author(s):  
B. Al-Sady ◽  
E. A. Kikis ◽  
E. Monte ◽  
P. H. Quail
Keyword(s):  
Transcription Factor ◽  
Factor Function

scholarly journals AP1 Transcription Factors in Epidermal Differentiation and Skin Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Richard L. Eckert ◽  
Gautam Adhikary ◽  
Christina A. Young ◽  
Ralph Jans ◽  
James F. Crish ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Dominant Negative ◽  
Epidermal Differentiation ◽  
Cancer Development ◽  
Multiple Cells ◽  
Different Levels ◽  
Factor Function

AP1 (jun/fos) transcription factors (c-jun, junB, junD, c-fos, FosB, Fra-1, and Fra-2) are key regulators of epidermal keratinocyte survival and differentiation and important drivers of cancer development. Understanding the role of these factors in epidermis is complicated by the fact that each protein is expressed, at different levels, in multiple cells layers in differentiating epidermis, and because AP1 transcription factors regulate competing processes (i.e., proliferation, apoptosis, and differentiation). Variousin vivogenetic approaches have been used to study these proteins including targeted and conditional knockdown, overexpression, and expression of dominant-negative inactivating AP1 transcription factors in epidermis. Taken together, these studies suggest that individual AP1 transcription factors have different functions in the epidermis and in cancer development and that altering AP1 transcription factor function in the basal versus suprabasal layers differentially influences the epidermal differentiation response and disease and cancer development.

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