The 185delAG mutation (c.68_69delAG) in theBRCA1 gene triggers translation reinitiation at a downstream AUG codon

2006 ◽  
Vol 27 (10) ◽  
pp. 1024-1029 ◽  
Author(s):  
Monique Buisson ◽  
Olga Anczuków ◽  
Almoutassem B. Zetoune ◽  
Mark D. Ware ◽  
Sylvie Mazoyer
Keyword(s):  
185Delag Mutation

scholarly journals Absence of 185delAG mutation of the BRCA1 gene and 6174delT mutation of the BRCA2 gene in Ashkenazi Jewish men with prostate cancer

1998 ◽  
Vol 78 (6) ◽  
pp. 771-773 ◽  
Author(s):  
S Lehrer ◽  
F Fodor ◽  
RG Stock ◽  
NN Stone ◽  
C Eng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Brca2 Gene ◽  
Brca1 Gene ◽  
Ashkenazi Jewish ◽  
185Delag Mutation

CdSe Quantum Dots Based Nano-Biosensor for Detection of 185delAG Mutation in BRCA1 Gene, Responsible for Breast Cancer

2017 ◽  
Vol 27 (6) ◽  
pp. 1911-1917 ◽  
Author(s):  
Bagher Eftekhari-Sis ◽  
Sajede Karaminejad ◽  
Fatemeh Malekan ◽  
Hessamaddin Younesi Araghi ◽  
Ali Akbari
Keyword(s):  
Breast Cancer ◽  
Quantum Dots ◽  
Brca1 Gene ◽  
Cdse Quantum Dots ◽  
185Delag Mutation

scholarly journals Germline mutations in the BRCA1 gene predisposing to breast and ovarian cancers in Upper Silesia population.

2002 ◽  
Vol 49 (2) ◽  
pp. 351-356 ◽  
Author(s):  
Ewa Grzybowska ◽  
Marzena Siemińska ◽  
Helena Zientek ◽  
Ewa Kalinowska ◽  
Jadwiga Michalska ◽  
...  
Keyword(s):  
Bilateral Breast Cancer ◽  
Brca1 Gene ◽  
Germline Mutations ◽  
Ovarian Cancers ◽  
Frequent Mutations ◽  
Allele Specific ◽  
Specific Amplification ◽  
185Delag Mutation ◽  
Healthy Persons ◽  
Pcr Test

Germline mutations in the BRCA1 or BRCA2 genes predispose their carriers to breast or/and ovary cancers during their lifetime. The most frequent mutations: 5382insC, 185delAG, C61G and 4153delA in BRCA1, and 6174delT and 9631delC in BRCA2 were studied in a group of 148 probands admitted for genetic counseling, using allele-specific amplification (ASA) PCR test. Fifteen carriers of three different mutations: 5382insC, 185delAG and C61G in BRCA1 were found. Two families carried the 185delAG mutation and additional two C61G in BRCA1. Nobody carried the mutation 4153delA in BRCA1 nor 6174delT or 9631delC in BRCA2. Most of the carriers of a germline mutation were observed among the patients who developed bilateral breast cancer (17%). The lowest frequency of the germline mutations was found in the healthy persons who had two or more relatives affected with breast or ovarian cancer.

Sign in / Sign up

Export Citation Format

Share Document