Increased energy expenditure during posture maintenance and exercise in early Parkinson disease

Tal Margaliot Kalifa; Nadav Ziv; Hagai Bergman; Samir Nusair; David Arkadir

doi:10.1002/hsr2.14

Increased energy expenditure during posture maintenance and exercise in early Parkinson disease

Health Science Reports ◽

10.1002/hsr2.14 ◽

2017 ◽

Vol 1 (1) ◽

pp. e14 ◽

Cited By ~ 1

Author(s):

Tal Margaliot Kalifa ◽

Nadav Ziv ◽

Hagai Bergman ◽

Samir Nusair ◽

David Arkadir

Keyword(s):

Energy Expenditure ◽

Parkinson Disease ◽

Posture Maintenance

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A compendium of G-protein–coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure

Clinical Science ◽

10.1042/cs20190579 ◽

2020 ◽

Vol 134 (5) ◽

pp. 473-512 ◽

Cited By ~ 5

Author(s):

Ryan P. Ceddia ◽

Sheila Collins

Keyword(s):

Adipose Tissue ◽

Energy Expenditure ◽

Signaling Pathways ◽

G Protein ◽

Uncoupling Protein ◽

Beige Adipocytes ◽

Nucleotide Regulation ◽

Ucp1 Expression ◽

Thermogenic Adipocytes ◽

G Protein Coupled

Abstract With the ever-increasing burden of obesity and Type 2 diabetes, it is generally acknowledged that there remains a need for developing new therapeutics. One potential mechanism to combat obesity is to raise energy expenditure via increasing the amount of uncoupled respiration from the mitochondria-rich brown and beige adipocytes. With the recent appreciation of thermogenic adipocytes in humans, much effort is being made to elucidate the signaling pathways that regulate the browning of adipose tissue. In this review, we focus on the ligand–receptor signaling pathways that influence the cyclic nucleotides, cAMP and cGMP, in adipocytes. We chose to focus on G-protein–coupled receptor (GPCR), guanylyl cyclase and phosphodiesterase regulation of adipocytes because they are the targets of a large proportion of all currently available therapeutics. Furthermore, there is a large overlap in their signaling pathways, as signaling events that raise cAMP or cGMP generally increase adipocyte lipolysis and cause changes that are commonly referred to as browning: increasing mitochondrial biogenesis, uncoupling protein 1 (UCP1) expression and respiration.

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