CHEMOTHERAPY IN HIV-POSITIVE PATIENTS WITH NON-HODGKIN LYMPHOMA: A SINGLE INSTITUTION RETROSPECTIVE STUDY

2019 ◽  
Vol 37 ◽  
pp. 532-532
Author(s):  
D. Dalu ◽  
C. Fasola ◽  
G. Bombonati ◽  
D. De Francesco
Keyword(s):  
Retrospective Study ◽  
Hodgkin Lymphoma ◽  
Hiv Positive ◽  
Single Institution ◽  
Non Hodgkin Lymphoma

Profiling of the Risk Factors and Designing of a Model to Identify Ischemic Stroke in Patients with Non-Hodgkin Lymphoma: A Multicenter Retrospective Study

2020 ◽  
Vol 83 (1) ◽  
pp. 41-48
Author(s):  
Yunfei Wei ◽  
Qingqing Yang ◽  
Qixiong Qin ◽  
Ya Chen ◽  
Xuemei Quan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Retrospective Study ◽  
Hodgkin Lymphoma ◽  
Multiple Logistic Regression Analysis ◽  
Elevated Serum ◽  
Non Hodgkin Lymphoma ◽  
Independent Risk Factors ◽  
Identification Model ◽  
D Dimer

Background: The occurrence of ischemic stroke in patients with non-Hodgkin lymphoma (NHL) is not well understood. This study aimed to determine independent risk factors to identity ischemic stroke in non-Hodgkin lymphoma-associated ischemic stroke (NHLAIS) patients. Methods: This retrospective study was conducted on NHLAIS patients and age- and gender-matched NHL patients. We collected clinical data of patients in both groups and used multiple logistic regression analysis to identify independent risk factors for NHLAIS. A receiver operating characteristic (ROC) analysis was used to establish an identification model based on potential risk factors of NHLAIS. Results: Sixty-three NHLAIS patients and 63 NHL patients were enrolled. Stage III/IV (58/63, 92.1%) and multiple arterial infarcts (44/63, 69.8%) were common among NHLAIS patients. Notably, NHLAIS patients had higher levels of serum fibrinogen (FIB), D-dimer, and ferritin (SF) and prolonged thromboplastin time and prothrombin time (PT) compared with NHL patients (all p < 0.05). Elevated FIB, D-dimer, and SF and prolonged PT were independent risk factors for NHLAIS. The area under the ROC curve of the identification model of NHLAIS patients was largest compared to that of other risk factors (0.838, 95% confidence interval: 0.759–0.899) (p < 0.05). Conclusion: This study reveals that elevated serum FIB, D-dimer, and SF and prolonged PT are potential independent risk factors of NHLAIS. The identification model established in this study may help monitor NHL patients who are at high risk of developing NHLAIS.

scholarly journals HMG-CoA reductase inhibitors (statins) use and risk of non-Hodgkin lymphoma in HIV-positive persons

AIDS ◽  
2011 ◽  
Vol 25 (14) ◽  
pp. 1771-1777 ◽  
Author(s):  
Chun Chao ◽  
Lanfang Xu ◽  
Donald I. Abrams ◽  
William J. Towner ◽  
Michael A. Horberg ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Hiv Positive ◽  
Hmg Coa Reductase ◽  
Non Hodgkin Lymphoma ◽  
Reductase Inhibitors ◽  
Hmg Coa Reductase Inhibitors ◽  
Coa Reductase

PROGNOSTIC FACTORS OF NON-HODGKIN LYMPHOMA: RETROSPECTIVE STUDY IN UNIT BLOOD SERVICE OF THE INTERNAL MEDICINE DANTEC IN DAKAR (SENEGAL)

2015 ◽  
Vol 6 ◽  
pp. 1
Author(s):  
Fatou Samba Diago Ndiaye ◽  
Seynabou Fall ◽  
Atoumane Faye ◽  
Nafissatou Diagne ◽  
Awa Cheikh Ndaw ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Prognostic Factors ◽  
Retrospective Study ◽  
Hodgkin Lymphoma ◽  
Non Hodgkin Lymphoma

scholarly journals The Cancer-Associated Virus Landscape in HIV Patients with Oral Hairy Leukoplakia, Kaposi's Sarcoma, and Non-Hodgkin Lymphoma

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Peter D. Burbelo ◽  
Joseph A. Kovacs ◽  
Jason Wagner ◽  
Ahmad Bayat ◽  
Craig S. Rhodes ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Hiv Positive ◽  
Infectious Agents ◽  
Hiv Patients ◽  
Non Hodgkin Lymphoma ◽  
Oral Hairy Leukoplakia ◽  
Hairy Leukoplakia ◽  
Antibody Levels

Although HIV-positive patients are at higher risk for developing a variety of infection-related cancers, the prevalence of infections with the seven known cancer-associated viruses has not been studied. Luciferase immunoprecipitation systems were used to evaluate antiviral antibodies in four 23-person groups: healthy blood donors and HIV-infected patients with oral hairy leukoplakia (OLP), Kaposi's sarcoma (KS), or non-Hodgkin lymphoma (NHL). Antibody profiling revealed that all HIV-positive individuals were strongly seropositive for anti-gp41 and antireverse transcriptase antibodies. However, anti-p24 HIV antibody levels were highly variable and some OLP and KS patients demonstrated weak or negative responses. Profiling two EBV antigens revealed no statistical difference in antibody levels among the three HIV-infected groups. A high frequency of KSHV infection was detected in HIV patients including 100% of KS, 78% of OLP, and 57% of NHL patients. Most HIV-infected subjects (84%) showed anti-HBV core antibodies, but only a few showed antibodies against HCV. MCV seropositivity was also common (94%) in the HIV-infected individuals and KS patients showed statistically higher antibody levels compared to the OLP and NHL patients. Overall, 68% of the HIV-infected patients showed seropositivity with at least four cancer-associated viruses. Antibody profiles against these and other infectious agents could be useful for enhancing the clinical management of HIV patients.

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