Trifluoromethylpyridine-SubstitutedN-Heterocyclic Carbenes Related to Natural Products: Synthesis, Structure, and Potential Antitumor Activity of some Corresponding Gold(I), Rhodium(I), and Iridium(I) Complexes

2016 ◽  
Vol 99 (6) ◽  
pp. 469-481 ◽  
Author(s):  
Elena Maftei ◽  
Catalin V. Maftei ◽  
Peter G. Jones ◽  
Matthias Freytag ◽  
M. Heiko Franz ◽  
...  
Keyword(s):  
Natural Products ◽  
Antitumor Activity ◽  
Heterocyclic Carbenes ◽  
Potential Antitumor ◽  
Natural Products Synthesis

Novel 1,2,4-oxadiazoles and trifluoromethylpyridines related to natural products: synthesis, structural analysis and investigation of their antitumor activity

Tetrahedron ◽  
2016 ◽  
Vol 72 (9) ◽  
pp. 1185-1199 ◽  
Author(s):  
Catalin V. Maftei ◽  
Elena Fodor ◽  
Peter G. Jones ◽  
Constantin G. Daniliuc ◽  
M. Heiko Franz ◽  
...  
Keyword(s):  
Natural Products ◽  
Structural Analysis ◽  
Antitumor Activity ◽  
Natural Products Synthesis

Natural Products from Cyanobacteria with Antimicrobial and Antitumor Activity

2014 ◽  
Vol 14 (9) ◽  
pp. 820-828 ◽  
Author(s):  
Maria Silva-Stenico ◽  
Ramon Kaneno ◽  
Fabiana Zambuzi ◽  
Marcelo Vaz ◽  
Danillo Alvarenga ◽  
...  
Keyword(s):  
Natural Products ◽  
Antitumor Activity

Application of a Validated QSTR Model for Repurposing COX-2 Inhibitor Coumarin Derivatives as Potential Antitumor Agents

2019 ◽  
Vol 19 (13) ◽  
pp. 1121-1128 ◽  
Author(s):  
Gulcin Tugcu ◽  
Hande Sipahi ◽  
Ahmet Aydin
Keyword(s):  
Antitumor Activity ◽  
Drug Development ◽  
Linear Model ◽  
Cell Lines ◽  
Cyclooxygenase 2 ◽  
Large Set ◽  
Coumarin Derivatives ◽  
Antitumor Compounds ◽  
Cyclooxygenase 2 Inhibitors ◽  
Potential Antitumor

Background: The discovery of novel potent molecules for both cancer prevention and treatment has been continuing over the past decade. In recent years, identification of new, potent, and safe anticancer agents through drug repurposing has been regarded as an expeditious alternative to traditional drug development. The cyclooxygenase-2 is known to be over-expressed in several types of human cancer. For this reason cyclooxygenase-2 inhibition may be useful tool for cancer chemotherapy. Objective: The first aim of the study was to develop a validated linear model to predict antitumor activity. Subsequently, applicability of the model for repurposing these cyclooxygenase-2 inhibitors as antitumor compounds to abridge drug development process. Method: We performed a quantitative structure-toxicity relationship (QSTR) study on a set of coumarin derivatives using a large set of molecular descriptors. A linear model predicting growth inhibition on leukemia CCRF cell lines was developed and consequently validated internally and externally. Accordingly, the model was applied on a set of 143 cyclooxygenase-2 inhibitor coumarin derivatives to explore their antitumor activity. Results: The results indicated that the developed QSAR model would be useful for estimating inhibitory activity of coumarin derivatives on leukemia cell lines. Electronegativity was found to be a prominent property of the molecules in describing antitumor activity. The applicability domain of the developed model highlighted the potential antitumor compounds. Conclusion: The promising results revealed that applied integrated in silico approach for repurposing by combining both the biological activity similarity and the molecular similarity via the computational method could be efficiently used to screen potential antitumor compounds among cyclooxygenase-2 inhibitors.

Current Status on Natural Products with Antitumor Activity from Brazilian Marine Sponges

2012 ◽  
Vol 13 (1) ◽  
pp. 235-244 ◽  
Author(s):  
Mario Luiz Conte da Frota Junior ◽  
Renata Biegelmeyer da Silva ◽  
Beatriz Mothes ◽  
Amelia Teresinha Henriques ◽  
Jose Claudio Fonseca Moreira
Keyword(s):  
Natural Products ◽  
Antitumor Activity ◽  
Marine Sponges ◽  
Current Status

Recent applications of asymmetric organocatalytic annulation reactions in natural product synthesis

2021 ◽  
Author(s):  
Nengzhong Wang ◽  
Zugen Wu ◽  
Junjie Wang ◽  
Nisar Ullah ◽  
Yixin Lu
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Natural Product Synthesis ◽  
Natural Products Synthesis

A comprehensive and updated summary of asymmetric organocatalytic annulation reactions is presented; in particular, the applications of these annulation strategies to natural products synthesis are highlighted.

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