Copper/Graphene/Clay Nanohybrid: A Highly Efficient Heterogeneous Nanocatalyst for the Synthesis of Novel 1,2,3-Triazolyl Carboacyclic Nucleosidesvia‘Click’Huisgen1,3-Dipolar Cycloaddition

2015 ◽  
Vol 98 (9) ◽  
pp. 1210-1224 ◽  
Author(s):  
Mohammad Navid Soltani Rad ◽  
Somayeh Behrouz ◽  
S. Jafar Hoseini ◽  
Hasan Nasrabadi ◽  
Maryam Saberi Zare
Keyword(s):  
Dipolar Cycloaddition ◽  
Heterogeneous Nanocatalyst ◽  
Highly Efficient

Copper/GanPhos-Catalyzed 1,3-Dipolar Cycloaddition of Azo­methine Ylides: An Efficient Access to Chiral Pyrrolidine Spirocycles

Synthesis ◽  
2020 ◽  
Author(s):  
Zhenjie Gan ◽  
Er-Qing Li ◽  
Ke Li ◽  
Hui Zhang
Keyword(s):  
Optically Active ◽  
Azomethine Ylides ◽  
Dipolar Cycloaddition ◽  
Reaction Conditions ◽  
Highly Efficient ◽  
Efficient Access ◽  
Stereogenic Centers

AbstractA highly efficient copper/GanPhos-catalyzed 1,3-dipolar cyclo­addition­ of azomethine ylides is reported. This viable transformation provides a series of optically active spiro[dihydronaphthalene-2,3′-pyrrolidine]s, bearing one spiro quaternary and three tertiary stereogenic centers, in good yields and with high ee values. This protocol features high diastereo- and enantioselectivity, broad substrate scope and mild reaction conditions.

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