Two New Megastigmane Glycosides and a New Iridoid Glycoside from Gelsemium elegans

2011 ◽  
Vol 94 (6) ◽  
pp. 1130-1138 ◽  
Author(s):  
Qiu-Ping Zhang ◽  
Bin-Feng Zhang ◽  
Gui-Xin Chou ◽  
Zheng-Tao Wang
Keyword(s):  
Iridoid Glycoside ◽  
Megastigmane Glycosides

scholarly journals Two Labdane Diterpene and Megastigmane Glycosides from Aquilegia hybrida

2008 ◽  
Vol 56 (7) ◽  
pp. 1009-1012 ◽  
Author(s):  
Hitoshi Yoshimitsu ◽  
Makiko Nishida ◽  
Toshihiro Nohara
Keyword(s):  
Labdane Diterpene ◽  
Megastigmane Glycosides

A new iridoid glycoside from Gardenia jasminoides

2007 ◽  
Vol 18 (10) ◽  
pp. 1221-1223 ◽  
Author(s):  
Xiao Qin Zhou ◽  
Zhi Ming Bi ◽  
Ping Li ◽  
Dan Tang ◽  
Hai Xia Cai
Keyword(s):  
Iridoid Glycoside ◽  
Gardenia Jasminoides

scholarly journals Cornel Iridoid Glycoside Improves Locomotor Impairment and Decreases Spinal Cord Damage in Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-12
Author(s):  
Wen-jing Tang ◽  
Deng-lei Ma ◽  
Cui-cui Yang ◽  
Li Zhang ◽  
Ya-li Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Rating Scale ◽  
Iridoid Glycoside ◽  
Neurotrophin Receptor ◽  
Intragastric Administration ◽  
P75 Neurotrophin Receptor ◽  
Lesion Site ◽  
Cord Injury ◽  
Locomotor Impairment ◽  
Cornel Iridoid Glycoside

Purpose. This study was to investigate the effects of cornel iridoid glycoside (CIG) on spinal cord injury (SCI) in rats. Methods. The thoracic cord (at T9) of rats was injured by clip compression for 30 sec. Locomotor function was assessed using the Basso, Beattie, and Bresnahan (BBB) rating scale. Neuroanatomic stereological parameters as well as Nogo-A, p75 neurotrophin receptor (p75NTR), and ROCKII expression were measured by histological processing, immunohistochemistry, and stereological analyses. The axons passing through the lesion site were detected by BDA tracing. Results. Intragastric administration of CIG (60 and 180 mg/kg) improved the locomotor impairment at 10, 17, 24, and 31 days post-injury (dpi) compared with untreated SCI model rats. CIG treatment decreased the volume of the lesion epicenter (LEp) and increased the volume of spared tissue and the number of surviving neurons in the injured spinal cord at 31 dpi. CIG promoted the growth of BDA-positive axons and their passage through the lesion site and decreased the expression of Nogo-A, p75NTR, and ROCKII both in and around the LEp. Conclusion. CIG improved the locomotor impairment, decreased tissue damage, and downregulated the myelin-associated inhibition signaling pathway in SCI rats. The results suggest that CIG may be beneficial for SCI therapy.

Specioside: A New Iridoid Glycoside From Catalpa speciosa

1980 ◽  
Vol 43 (4) ◽  
pp. 524-526 ◽  
Author(s):  
Sha'aban F. El-Naggar ◽  
Raymond W. Doskotch
Keyword(s):  
Iridoid Glycoside

Capturing Acyltransferase(s) Transforming Final Step in the Biosynthesis of a Major Iridoid Glycoside, (Picroside-II) in a Himalayan Medicinal Herb, Picrorhiza kurroa

2021 ◽  
Author(s):  
ANJALI KHARB ◽  
Shilpa Sharma ◽  
Ashish Sharma ◽  
Neeti Nirwal ◽  
Roma Pandey ◽  
...  
Keyword(s):  
Gene Expression ◽  
De Novo ◽  
Iridoid Glycoside ◽  
Ligand Docking ◽  
Comparative Transcriptome ◽  
Picrorhiza Kurroa ◽  
Final Structure ◽  
Picroside Ii ◽  
Preferential Binding ◽  
Real Time Qpcr

Abstract BackgroundPicrorhiza kurroa has been reported as an age-old ayurvedic hepatoprotection to treat hepatic disorders due to the presence of iridoids such as picroside-II (P-II), picroside-I, and kutkoside. The acylation of catalpol and vanilloyl coenzyme A by acyltransferases (ATs) is critical step in P-II biosynthesis. Since accumulation of P-II occurs only in roots, rhizomes and stolons, uprooting of this critically endangered herb has been the only source of this compound. Recently, we reported that P-II acylation likely happen in roots, while stolons serve as the vital P-II storage compartment. Therefore, developing an alternate engineered platform for P-II biosynthesis require identification of P-II specific AT/s.Methods and results In that direction, egg-NOG function annotated 815 ATs from de novo RNA sequencing of tissue culture based ‘shoots-only’ system and nursery grown shoots, roots, and stolons varying in P-II content, were cross-compared in silico to arrive at ATs sequences unique and/or common to stolons and roots. Verification for organ and accession-wise upregulation in gene expression of these ATs by qPCR has shortlisted six putative ‘P-II-forming’ ATs. Further, six-frame translation, ab initio protein structure modelling and protein-ligand molecular docking of these ATs signified one MBOAT domain containing AT with preferential binding to the vanillic acid CoA thiol ester as well as with P-II., implying that this could be potential AT decorating final structure of P-II. ConclusionOrgan-wise comparative transcriptome mining coupled with reverse transcription real time qPCR and protein-ligand docking led to the identification of an acyltransferases, contributing to the final structure of P-II.

Two iridoid glycoside caffeoyl esters from Premna odorata

1989 ◽  
Vol 28 (2) ◽  
pp. 513-515 ◽  
Author(s):  
Hideaki Otsuka ◽  
Naoko Kubo ◽  
Kazuo Yamasaki ◽  
William G. Padolina
Keyword(s):  
Iridoid Glycoside

scholarly journals A New Iridoid Glycoside from Santisukia pagetii

Heterocycles ◽  
2022 ◽  
Vol 104 (3) ◽  
Author(s):  
Tripetch Kanchanapoom ◽  
Poolsak Sahakitpichan ◽  
Nitirat Chimnoi ◽  
Chutima Srinroch ◽  
Chaleaw Petchthong ◽  
...  
Keyword(s):  
Iridoid Glycoside

Gmelinoiridoside, a New Iridoid Glycoside from Gmelina philippensis

2014 ◽  
Author(s):  
Jih-Jung Chen ◽  
Ming-Jen Cheng ◽  
Hsiang-Ruei Liao ◽  
Ping-Jyun Sung ◽  
Tai-Chi Wang ◽  
...  
Keyword(s):  
Iridoid Glycoside

Alangionosides CF, megastigmane glycosides from Alangium premnifolium

1995 ◽  
Vol 38 (6) ◽  
pp. 1431-1435 ◽  
Author(s):  
Hideaki Otsuka ◽  
Kenji Kamada ◽  
Masami Yao ◽  
Kaori Yuasa ◽  
Ikuko Kida ◽  
...  
Keyword(s):  
Megastigmane Glycosides
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