Rapid Determination of Gallamine Triethiodide (Flaxedil®) and Pancuronium Bromide (Pavulon®) in Pharmaceutical and Urine Matrices by Means of Modified-Carbon-Paste Ion-Selective Electrodes

2005 ◽  
Vol 88 (4) ◽  
pp. 861-872 ◽  
Author(s):  
Alaa A. Salem ◽  
Barsoum N. Barsoum ◽  
Dalia M. El Said
Keyword(s):  
Rapid Determination ◽  
Pancuronium Bromide ◽  
Ion Selective Electrodes ◽  
Carbon Paste ◽  
Gallamine Triethiodide

All-Solid-State, PVC Membrane, and Carbon Paste Ion-Selective Electrodes for Determination of Donepezil Hydrochloride in Pharmaceutical Formulation

2017 ◽  
Vol 100 (5) ◽  
pp. 1414-1419
Author(s):  
Nesreen Khamees ◽  
Tagreed Abdel-Fattah Mohamed ◽  
Abeer Rashad Derar ◽  
Azza Aziz
Keyword(s):  
Solid State ◽  
Pharmaceutical Formulation ◽  
Pvc Membrane ◽  
Ion Selective Electrodes ◽  
Carbon Paste ◽  
Pharmaceutical Tablets ◽  
Carbon Paste Electrodes ◽  
Potentiometric Response ◽  
Donepezil Hydrochloride

Abstract All-solid-state, polyvinyl chloride (PVC) membrane, and carbon paste potentiometric ion-selective electrodes (ISEs) were proposed for the determination of donepezil hydrochloride (DON) in the drug substance and a pharmaceutical formulation. The potentiometric response toward DON was based on the existence ofdonepezil-tetraphenyl borate (DON-TPB) in a PVC membrane or a carbon paste in the presence of dioctylphthalate. In contrast, the solid-state electrode was prepared by direct incorporation of DON-TPB into a commercial nail varnish without external additives. The electrodes exhibited Nernstian slopes of 55.0, 57.0, and 53.0 mV/decade over the concentration ranges of 1 × 10−5 to 1 × 10−3, 1 × 10−4 to 10−2, and 1 × 10−4 to 5 × 10−3 for the solid-state, PVC membrane, and carbon paste electrodes, respectively. The response of the electrodes is independent of pH in the range of 2–≤8. The electrodes showed good selectivity for DON with respect to a number of inorganic cations and amino acids. The electrodes were used for the determination of DON in pure solution and in pharmaceutical tablets with high accuracy (±2%) and precision (RSD ≤2%). The solid-state electrode is simple, economical, and rapid when compared to the PVC membrane and carbon paste electrodes.

Simple and rapid determination of iodide in table salt by stripping potentiometry at a carbon-paste electrode

2002 ◽  
Vol 372 (7-8) ◽  
pp. 795-800 ◽  
Author(s):  
Ivan Švancara ◽  
Božidar Ogorevc ◽  
Milko Nović ◽  
Karel Vytřas
Keyword(s):  
Carbon Paste Electrode ◽  
Rapid Determination ◽  
Table Salt ◽  
Carbon Paste ◽  
Paste Electrode
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