scholarly journals Dorsal and ventral mossy cells differ in their axonal projections throughout the dentate gyrus of the mouse hippocampus

Hippocampus ◽  
2021 ◽  
Vol 31 (5) ◽  
pp. 522-539 ◽  
Author(s):  
Justin J. Botterill ◽  
Kathleen J. Gerencer ◽  
K. Yaragudri Vinod ◽  
David Alcantara‐Gonzalez ◽  
Helen E. Scharfman
Keyword(s):  
Dentate Gyrus ◽  
Mossy Cells ◽  
Axonal Projections ◽  
Mouse Hippocampus

scholarly journals Dorsal and ventral mossy cells differ in their long-range axonal projections throughout the dentate gyrus of the mouse hippocampus

2020 ◽  
Author(s):  
Justin J. Botterill ◽  
Kathleen J. Gerencer ◽  
K. Yaragudri Vinod ◽  
David Alcantara-Gonzalez ◽  
Helen E. Scharfman
Keyword(s):  
Long Range ◽  
Molecular Layer ◽  
Calcitonin Receptor ◽  
Mossy Cells ◽  
Axonal Projections ◽  
Mouse Hippocampus ◽  
The Difference ◽  
Primary Projection ◽  
Surprising Finding ◽  
Mouse Lines

ABSTRACTGlutamatergic hilar mossy cells (MCs) have axons that terminate both near and far from their cell body but stay within the DG, making synapses in the inner molecular layer primarily. The long-range axons are considered the primary projection, and extend throughout the DG ipsilateral to the soma, and project to the contralateral DG. The specificity of long-range MC axons for the inner molecular layer (IML) has been considered to be a key characteristic of the DG. In the present study we made the surprising finding that dorsal MC axons are an exception to this rule. We used two mouse lines that allow for Cre-dependent viral labeling of MCs and their axons: dopamine receptor d2 (Drd2-Cre) and calcitonin receptor-like receptor (Crlr-Cre). A single viral injection into the dorsal DG to label dorsal MCs resulted in labeling of MC axons in both the IML and middle molecular layer (MML). Interestingly, this broad termination of MC axons applied to all long-range axons. In contrast, long-range axons of ventral MCs mainly terminated in the IML, consistent with the literature. Taken together, these results suggest that dorsal and ventral MCs differ significantly in their axonal projections, and the difference is primarily in their long-range projections. Since those projections are thought to terminate primarily on GCs, the results suggest a dorsal-ventral difference in MC activation of GCs. The surprising difference in dorsal and ventral MC projections should therefore be considered when evaluating dorsal-ventral differences in DG function.

scholarly journals Mossy Cells in the Dorsal and Ventral Dentate Gyrus Differ in their Patterns of Axonal Projections

2020 ◽  
pp. JN-RM-2455-20
Author(s):  
Carolyn R. Houser ◽  
Zechun Peng ◽  
Xiaofei Wei ◽  
Christine S. Huang ◽  
Istvan Mody
Keyword(s):  
Dentate Gyrus ◽  
Mossy Cells ◽  
Axonal Projections

Survival of mossy cells of the hippocampal dentate gyrus in humans with mesial temporal lobe epilepsy

2009 ◽  
Vol 111 (6) ◽  
pp. 1237-1247 ◽  
Author(s):  
László Seress ◽  
Hajnalka Ábrahám ◽  
Zsolt Horváth ◽  
Tamás Dóczi ◽  
József Janszky ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Temporal Lobe ◽  
Pyramidal Neurons ◽  
Hippocampal Sclerosis ◽  
Mesial Temporal Lobe Epilepsy ◽  
Drug Resistant ◽  
Hippocampal Dentate Gyrus ◽  
Mossy Cells ◽  
Mesial Temporal Lobe

Object Hippocampal sclerosis can be identified in most patients with mesial temporal lobe epilepsy (TLE). Surgical removal of the sclerotic hippocampus is widely performed to treat patients with drug-resistant mesial TLE. In general, both epilepsy-prone and epilepsy-resistant neurons are believed to be in the hippocampal formation. The hilar mossy cells of the hippocampal dentate gyrus are usually considered one of the most vulnerable types of neurons. The aim of this study was to clarify the fate of mossy cells in the hippocampus in epileptic humans. Methods Of the 19 patients included in this study, 15 underwent temporal lobe resection because of drug-resistant TLE. Four patients were used as controls because they harbored tumors that had not invaded the hippocampus and they had experienced no seizures. Histological evaluation of resected hippocampal tissues was performed using immunohistochemistry. Results Mossy cells were identified in the control as well as the epileptic hippocampi by using cocaine- and amphetamine-regulated transcript peptide immunohistochemistry. In most cases the number of mossy cells was reduced and thorny excrescences were smaller in the epileptic hippocampi than in controls; however, there was a significant loss of pyramidal cells and a partial loss of granule cells in the same epileptic hippocampi in which mossy cell loss was apparent. The loss of mossy cells could be correlated with the extent of hippocampal sclerosis, patient age at seizure onset, duration of epilepsy, and frequency of seizures. Conclusions In many cases large numbers of mossy cells were present in the hilus of the dentate gyrus when most pyramidal neurons of the CA1 and CA3 areas of the Ammon's horn were lost, suggesting that mossy cells may not be more vulnerable to epileptic seizures than the hippocampal pyramidal neurons.

scholarly journals Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory

Science ◽  
2018 ◽  
Vol 359 (6377) ◽  
pp. 787-790 ◽  
Author(s):  
Anh D. Bui ◽  
Theresa M. Nguyen ◽  
Charles Limouse ◽  
Hannah K. Kim ◽  
Gergely G. Szabo ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Dentate Gyrus ◽  
Mossy Cells ◽  
Convulsive Seizures

scholarly journals Differential Timing and Coordination of Neurogenesis and Astrogenesis in Developing Mouse Hippocampal Subregions

2020 ◽  
Vol 10 (12) ◽  
pp. 909
Author(s):  
Allison M. Bond ◽  
Daniel A. Berg ◽  
Stephanie Lee ◽  
Alan S. Garcia-Epelboim ◽  
Vijay S. Adusumilli ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Postnatal Development ◽  
Fundamental Principle ◽  
Mammalian Brain ◽  
Early Postnatal Development ◽  
Neocortical Development ◽  
Mouse Hippocampus ◽  
Cornu Ammonis ◽  
Low Levels ◽  
Differential Timing

Neocortical development has been extensively studied and therefore is the basis of our understanding of mammalian brain development. One fundamental principle of neocortical development is that neurogenesis and gliogenesis are temporally segregated processes. However, it is unclear how neurogenesis and gliogenesis are coordinated in non-neocortical regions of the cerebral cortex, such as the hippocampus, also known as the archicortex. Here, we show that the timing of neurogenesis and astrogenesis in the Cornu Ammonis (CA) 1 and CA3 regions of mouse hippocampus mirrors that of the neocortex; neurogenesis occurs embryonically, followed by astrogenesis during early postnatal development. In contrast, we find that neurogenesis in the dentate gyrus begins embryonically but is a protracted process which peaks neonatally and continues at low levels postnatally. As a result, astrogenesis, which occurs during early postnatal development, overlaps with the process of neurogenesis in the dentate gyrus. During all stages, neurogenesis overwhelms astrogenesis in the dentate gyrus. In addition, we find that the timing of peak astrogenesis varies by hippocampal subregion. Together, our results show differential timing and coordination of neurogenesis and astrogenesis in developing mouse hippocampal subregions and suggest that neurogenesis and gliogenesis occur simultaneously during dentate gyrus development, challenging the conventional principle that neurogenesis and gliogenesis are temporally separated processes.

scholarly journals Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus

Neuron ◽  
2017 ◽  
Vol 93 (3) ◽  
pp. 677-690.e5 ◽  
Author(s):  
Douglas GoodSmith ◽  
Xiaojing Chen ◽  
Cheng Wang ◽  
Sang Hoon Kim ◽  
Hongjun Song ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Granule Cells ◽  
Spatial Representations ◽  
Mossy Cells

scholarly journals Acute restraint stress decreases c-fos immunoreactivity in hilar mossy cells of the adult dentate gyrus

2017 ◽  
Vol 222 (5) ◽  
pp. 2405-2419 ◽  
Author(s):  
Jillian N. Moretto ◽  
Áine M. Duffy ◽  
Helen E. Scharfman
Keyword(s):  
Dentate Gyrus ◽  
Restraint Stress ◽  
Mossy Cells ◽  
Acute Restraint Stress
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