scholarly journals Speed modulation of hippocampal theta frequency and amplitude predicts water maze learning

Hippocampus ◽  
2020 ◽  
Author(s):  
Calvin K. Young ◽  
Ming Ruan ◽  
Neil McNaughton
Keyword(s):  
Water Maze ◽  
Maze Learning ◽  
Speed Modulation ◽  
Theta Frequency ◽  
Hippocampal Theta

scholarly journals Speed modulation of hippocampal theta frequency and power predicts water maze learning

2020 ◽  
Author(s):  
Calvin K. Young ◽  
Ming Ruan ◽  
Neil McNaughton
Keyword(s):  
Spatial Learning ◽  
Cognitive Processes ◽  
Water Maze ◽  
Maze Learning ◽  
Theta Oscillations ◽  
Movement Speed ◽  
Learning Rates ◽  
Speed Modulation ◽  
Theta Frequency ◽  
Hippocampal Theta

AbstractTheta oscillations in the hippocampus have many behavioural correlates, with the magnitude and vigour of ongoing movement being the most salient. Many consider correlates of locomotion with hippocampal theta to be a confound in delineating theta contributions to cognitive processes. But, theory and empirical experiments suggest theta-movement relationships are important if spatial navigation is to support higher cognitive processes. In the current study, we tested if variations in speed modulation of hippocampal theta can predict spatial learning rates in the water maze. Using multi-step regression, we find the magnitude and robustness of hippocampal theta frequency versus speed scaling can predict water maze learning rates. Using generalised linear models, we also demonstrate that speed and water maze learning are the best predictors of hippocampal theta frequency and power. Theta oscillations recorded from the supramammillary area showed much weaker, or non-existent, relationships, which supports the idea that hippocampal theta has specific roles in speed representation and spatial learning. Our findings suggest movement-speed correlations with hippocampal theta frequency may be actively used in spatial learning.

scholarly journals Speed modulation of hippocampal theta frequency correlates with spatial memory performance

Hippocampus ◽  
2013 ◽  
Vol 23 (12) ◽  
pp. 1269-1279 ◽  
Author(s):  
Gregory R. Richard ◽  
Ali Titiz ◽  
Anna Tyler ◽  
Gregory L. Holmes ◽  
Rod C. Scott ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Memory Performance ◽  
Speed Modulation ◽  
Theta Frequency ◽  
Hippocampal Theta

Minimal driving of hippocampal theta by the supramammillary nucleus during water maze learning

Hippocampus ◽  
2010 ◽  
Vol 21 (10) ◽  
pp. 1074-1081 ◽  
Author(s):  
Ming Ruan ◽  
Calvin K. Young ◽  
Neil McNaughton
Keyword(s):  
Water Maze ◽  
Maze Learning ◽  
Supramammillary Nucleus ◽  
Hippocampal Theta

REPETITIVE DEXTROMETHORPHAN AT ADOLESCENCE AFFECTS WATER MAZE LEARNING IN FEMALE RATS

2006 ◽  
Vol 116 (2) ◽  
pp. 91-101 ◽  
Author(s):  
HEE JEONG CHO ◽  
JAE GOO KIM ◽  
JOO YOUNG LEE ◽  
SEOUL LEE ◽  
JEONG WON JAHNG
Keyword(s):  
Water Maze ◽  
Maze Learning ◽  
Female Rats

scholarly journals Flexible theta sequence compression mediated via phase precessing interneurons

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Angus Chadwick ◽  
Mark CW van Rossum ◽  
Matthew F Nolan
Keyword(s):  
Action Potentials ◽  
High Capacity ◽  
Theta Oscillations ◽  
Sequence Generation ◽  
Spike Sequences ◽  
Theta Frequency ◽  
Neural Substrate ◽  
Hippocampal Theta ◽  
Novel Model ◽  
Sequence Compression

Encoding of behavioral episodes as spike sequences during hippocampal theta oscillations provides a neural substrate for computations on events extended across time and space. However, the mechanisms underlying the numerous and diverse experimentally observed properties of theta sequences remain poorly understood. Here we account for theta sequences using a novel model constrained by the septo-hippocampal circuitry. We show that when spontaneously active interneurons integrate spatial signals and theta frequency pacemaker inputs, they generate phase precessing action potentials that can coordinate theta sequences in place cell populations. We reveal novel constraints on sequence generation, predict cellular properties and neural dynamics that characterize sequence compression, identify circuit organization principles for high capacity sequential representation, and show that theta sequences can be used as substrates for association of conditioned stimuli with recent and upcoming events. Our results suggest mechanisms for flexible sequence compression that are suited to associative learning across an animal’s lifespan.

scholarly journals Optogenetic activation of SST-positive interneurons restores hippocampal theta oscillation impairment induced by soluble amyloid beta oligomersin vivo

2018 ◽  
Author(s):  
Hyowon Chung ◽  
Kyerl Park ◽  
Hyun Jae Jang ◽  
Michael M Kohl ◽  
Jeehyun Kwag
Keyword(s):  
Learning And Memory ◽  
Peak Power ◽  
Pyramidal Neurons ◽  
Hippocampal Slices ◽  
Field Potential ◽  
Theta Oscillations ◽  
Ca1 Pyramidal Neurons ◽  
Theta Frequency ◽  
Hippocampal Theta

AbstractAbnormal accumulation of amyloid β oligomers (AβO) is a hallmark of Alzheimer’s disease (AD), which leads to learning and memory deficits. Hippocampal theta oscillations that are critical in spatial navigation, learning and memory are impaired in AD. Since GABAergic interneurons, such as somatostatin-positive (SST+) and parvalbumin-positive (PV+) interneurons, are believed to play key roles in the hippocampal oscillogenesis, we asked whether AβO selectively impairs these SST+ and PV+ interneurons. To selectively manipulate SST+ or PV+ interneuron activity in mice with AβO pathologyin vivo, we co-injected AβO and adeno-associated virus (AAV) for expressing floxed channelrhodopsin-2 (ChR2) into the hippocampus of SST-Cre or PV-Cre mice. Local field potential (LFP) recordingsin vivoin these AβO–injected mice showed a reduction in the peak power of theta oscillations and desynchronization of spikes from CA1 pyramidal neurons relative to theta oscillations compared to those in control mice. Optogenetic-activation of SST+ but not PV+ interneurons in AβO–injected mice fully restored the peak power of theta oscillations and resynchronized the theta spike phases to a level observed in control mice.In vitrowhole-cell voltage-clamp recordings in CA1 pyramidal neurons in hippocampal slices treated with AβO revealed that short-term plasticity of SST+ interneuron inhibitory inputs to CA1 pyramidal neurons at theta frequency were selectively disrupted while that of PV+ interneuron inputs were unaffected. Together, our results suggest that dysfunction in inputs from SST+ interneurons to CA1 pyramidal neurons may underlie the impairment of theta oscillations observed in AβO-injected micein vivo.Our findings identify SST+ interneurons as a target for restoring theta-frequency oscillations in early AD.

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