scholarly journals A computational model of systems memory consolidation and reconsolidation

Hippocampus ◽  
2019 ◽  
Vol 30 (7) ◽  
pp. 659-677 ◽  
Author(s):  
Peter Helfer ◽  
Thomas R. Shultz
Keyword(s):  
Computational Model ◽  
Memory Consolidation ◽  
Memory Consolidation And Reconsolidation

Dissociable stages of human memory consolidation and reconsolidation

Nature ◽  
2003 ◽  
Vol 425 (6958) ◽  
pp. 616-620 ◽  
Author(s):  
Matthew P. Walker ◽  
Tiffany Brakefield ◽  
J. Allan Hobson ◽  
Robert Stickgold
Keyword(s):  
Memory Consolidation ◽  
Human Memory ◽  
Memory Consolidation And Reconsolidation

scholarly journals Selection of stimulus parameters for enhancing slow wave sleep events with a Neural-field theory thalamocortical computational model

2021 ◽  
Author(s):  
Felipe A. Torres ◽  
Patricio Orio ◽  
María-José Escobar
Keyword(s):  
Computational Model ◽  
Slow Wave ◽  
Memory Consolidation ◽  
Closed Loop ◽  
Slow Wave Sleep ◽  
Brain Activity ◽  
Sensory Stimulation ◽  
Sleep Spindles ◽  
Slow Oscillations ◽  
Closed Loop Stimulation

AbstractSlow-wave sleep cortical brain activity, conformed by slow-oscillations and sleep spindles, plays a key role in memory consolidation. The increase of the power of the slow-wave events, obtained by auditory sensory stimulation, positively correlates to memory consolidation performance. However, little is known about the experimental protocol maximizing this effect, which could be induced by the power of slow-oscillation, the number of sleep spindles, or the timing of both events’ co-occurrence. Using a mean-field model of thalamocortical activity, we studied the effect of several stimulation protocols, varying the pulse shape, duration, amplitude, and frequency, as well as a target-phase using a closed-loop approach. We evaluated the effect of these parameters on slow-oscillations (SO) and sleep-spindles (SP), considering: (i) the power at the frequency bands of interest, (ii) the number of SO and SP, (iii) co-occurrences between SO and SP, and (iv) synchronization of SP with the up-peak of the SO. The first three targets are maximized using a decreasing ramp pulse with a pulse duration of 50 ms. Also, we observed a reduction in the number of SO when increasing the stimulus energy by rising its amplitude. To assess the target-phase parameter, we applied closed-loop stimulation at 0º, 45º, and 90º of the phase of the narrow-band filtered ongoing activity, at 0.85 Hz as central frequency. The 0º stimulation produces better results in the power and number of SO and SP than the rhythmic or aleatory stimulation. On the other hand, stimulating at 45º or 90º change the timing distribution of spindles centers but with fewer co-occurrences than rhythmic and 0º phase. Finally, we propose the application of closed-loop stimulation at the rising zero-cross point using pulses with a decreasing ramp shape and 50 ms of duration for future experimental work.Author summaryDuring the non-REM (NREM) phase of sleep, events that are known as slow oscillations (SO) and spindles (SP) can be detected by EEG. These events have been associated with the consolidation of declarative memories and learning. Thus, there is an ongoing interest in promoting them during sleep by non-invasive manipulations such as sensory stimulation. In this paper, we used a computational model of brain activity that generates SO and SP, to investigate which type of sensory stimulus –shape, amplitude, duration, periodicity– would be optimal for increasing the events’ frequency and their co-occurrence. We found that a decreasing ramp of 50 ms duration is the most effective. The effectiveness increases when the stimulus pulse is delivered in a closed-loop configuration triggering the pulse at a target phase of the ongoing SO activity. A desirable secondary effect is to promote SPs at the rising phase of the SO oscillation.

Peripheral bacterial endotoxin administration triggers both memory consolidation and reconsolidation deficits in mice

2012 ◽  
Vol 26 (1) ◽  
pp. 109-121 ◽  
Author(s):  
Dinko Kranjac ◽  
Kristina A. McLinden ◽  
Lauren E. Deodati ◽  
Mauricio R. Papini ◽  
Michael J. Chumley ◽  
...  
Keyword(s):  
Memory Consolidation ◽  
Bacterial Endotoxin ◽  
Endotoxin Administration ◽  
Memory Consolidation And Reconsolidation

scholarly journals Skill reconsolidation does not operate at a rapid micro-timescale level

2022 ◽  
Author(s):  
Jasmine Herszage ◽  
Marlene Bönstrup ◽  
Leonardo G Cohen ◽  
Nitzan Censor
Keyword(s):  
Skill Acquisition ◽  
Memory Consolidation ◽  
Time Window ◽  
Sequence Data ◽  
Early Learning ◽  
Motor Sequence ◽  
Abundant Evidence ◽  
After Hours ◽  
Stages Of Learning ◽  
Memory Consolidation And Reconsolidation

Abundant evidence shows that consolidated memories are susceptible to modifications following their reactivation through reconsolidation. Processes of memory consolidation and reconsolidation have been commonly documented after hours or days. Motivated by studies showing rapid consolidation in early stages of skill acquisition, here we asked whether skill memories are susceptible to modifications through rapid reconsolidation, even at initial stages of learning. In a set of experiments, we collected crowdsourced online motor sequence data to test whether post-reactivation interference and enhancement occur through rapid reconsolidation. Results indicate that memories forming during early learning are not susceptible to interference nor to enhancement within a rapid reconsolidation time window, relative to control conditions. This set of evidence suggests that memory reconsolidation might be dependent on consolidation at the macro-timescale level, requiring hours or days to occur.

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