scholarly journals Functional connectivity along the anterior–posterior axis of hippocampal subfields in the ageing human brain

Hippocampus ◽  
2019 ◽  
Vol 29 (11) ◽  
pp. 1049-1062 ◽  
Author(s):  
Marshall A. Dalton ◽  
Cornelia McCormick ◽  
Flavia De Luca ◽  
Ian A. Clark ◽  
Eleanor A. Maguire
Keyword(s):  
Functional Connectivity ◽  
Human Brain ◽  
Hippocampal Subfields ◽  
Anterior Posterior ◽  
Anterior Posterior Axis

scholarly journals Differences in functional connectivity along the anterior-posterior axis of human hippocampal subfields

2018 ◽  
Author(s):  
Marshall A. Dalton ◽  
Cornelia McCormick ◽  
Eleanor A. Maguire
Keyword(s):  
High Resolution ◽  
Functional Connectivity ◽  
Functional Mri ◽  
Resting State ◽  
Structural Mri ◽  
List Type ◽  
Hippocampal Subfields ◽  
Anterior Posterior ◽  
Anterior Posterior Axis ◽  
Synaptic Circuit

AbstractThere is a paucity of information about how human hippocampal subfields are functionally connected to each other and to neighbouring extra-hippocampal cortices. In particular, little is known about whether patterns of functional connectivity (FC) differ down the anterior-posterior axis of each subfield. Here, using high resolution structural MRI we delineated the hippocampal subfields in healthy young adults. This included the CA fields, separating DG/CA4 from CA3, separating the pre/parasubiculum from the subiculum, and also segmenting the uncus. We then used high resolution resting state functional MRI to interrogate FC. We first analysed the FC of each hippocampal subfield in its entirety, in terms of FC with other subfields and with the neighbouring regions, namely entorhinal, perirhinal, posterior parahippocampal and retrosplenial cortices. Next, we analysed FC for different portions of each hippocampal subfield along its anterior-posterior axis, in terms of FC between different parts of a subfield, FC with other subfield portions, and FC of each subfield portion with the neighbouring cortical regions of interest. We found that intrinsic functional connectivity between the subfields aligned generally with the tri-synaptic circuit but also extended beyond it. Our findings also revealed that patterns of functional connectivity between the subfields and neighbouring cortical areas differed markedly along the anterior-posterior axis of each hippocampal subfield. Overall, these results contribute to ongoing efforts to characterise human hippocampal subfield connectivity, with implications for understanding hippocampal function.HighlightsHigh resolution resting state functional MRI scans were collectedWe investigated functional connectivity (FC) of human hippocampal subfieldsWe specifically examined FC along the anterior-posterior axis of subfieldsFC between subfields extended beyond the canonical tri-synaptic circuitDifferent portions of subfields showed different patterns of FC with neocortex

Resting state functional connectivity of the hippocampus along the anterior–posterior axis and its association with glutamatergic metabolism

Cortex ◽  
2016 ◽  
Vol 81 ◽  
pp. 104-117 ◽  
Author(s):  
Gerd Wagner ◽  
Alexander Gussew ◽  
Stefanie Köhler ◽  
Feliberto de la Cruz ◽  
Stefan Smesny ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Resting State Functional Connectivity ◽  
Anterior Posterior ◽  
Anterior Posterior Axis

scholarly journals Anterior-Posterior Axis of Hippocampal Subfields Across Psychoses: A B-SNIP Study

2021 ◽  
pp. 100037
Author(s):  
Elisabetta C. del Re ◽  
Victor Zeng ◽  
Ney Alliey-Rodriguez ◽  
Paulo Lizano ◽  
Nicolas Bolo ◽  
...  
Keyword(s):  
Hippocampal Subfields ◽  
Anterior Posterior ◽  
Anterior Posterior Axis
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