scholarly journals Immediate‐early gene Homer1a intranuclear transcription focus intensity as a measure of relative neural activation

Hippocampus ◽  
2018 ◽  
Vol 29 (6) ◽  
pp. 481-490
Author(s):  
Wing K. L. Witharana ◽  
Benjamin J. Clark ◽  
Vivek Trivedi ◽  
Lilia Mesina ◽  
Bruce L. McNaughton
Keyword(s):  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Neural Activation ◽  
Focus Intensity

scholarly journals 5-HT2A receptor loss does not alter acute fluoxetine-induced anxiety and exhibit sex-dependent regulation of cortical immediate early gene expression

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Minal Jaggar ◽  
Toshali Banerjee ◽  
Noelia Weisstaub ◽  
Jay A. Gingrich ◽  
Vidita A. Vaidya
Keyword(s):  
Immediate Early Gene ◽  
Brain Regions ◽  
Early Gene ◽  
Immediate Early ◽  
Neural Activation ◽  
Serum Corticosterone ◽  
Viral Oncogene ◽  
Female Mice ◽  
Murine Osteosarcoma ◽  
Viral Oncogene Homolog

Abstract Background: Acute treatment with the selective serotonin reuptake inhibitor (SSRI), fluoxetine (Flx), induces anxiety-like behavioral effects. The serotonin2A receptor (5-HT2A) is implicated in the modulation of anxiety-like behavior, however its contribution to the anxiogenic effects of acute Flx remains unclear. Here, we examined the role of the 5-HT2A receptor in the effects of acute Flx on anxiety-like behavior, serum corticosterone levels, neural activation and immediate early gene (IEG) expression in stress-responsive brain regions, using 5-HT2A receptor knockout (5-HT2A−/−) mice of both sexes. Methods: 5-HT2A−/− and wild-type (WT) male and female mice received a single administration of Flx or vehicle, and were examined for anxiety-like behavior, serum corticosterone levels, FBJ murine osteosarcoma viral oncogene homolog peptide (c-Fos) positive cell numbers in stress-responsive brain regions of the hypothalamus and prefrontal cortex (PFC), and PFC IEG expression. Results: The increased anxiety-like behavior and enhanced corticosterone levels evoked by acute Flx were unaltered in 5-HT2A−/− mice of both sexes. 5-HT2A−/− female mice exhibited a diminished neural activation in the hypothalamus in response to acute Flx. Further, 5-HT2A−/− male, but not female, mice displayed altered baseline expression of several IEGs (brain-derived neurotrophic factor (Bdnf), Egr2, Egr4, FBJ osteosarcoma gene (Fos), FBJ murine osteosarcoma viral oncogene homolog B (Fosb), Fos-like antigen 2 (Fosl2), Homer scaffolding protein (Homer) 1-3 (Homer1-3), Jun proto-oncogene (Jun)) in the PFC. Conclusion: Our results indicate that the increased anxiety and serum corticosterone levels evoked by acute Flx are not influenced by 5-HT2A receptor deficiency. However, the loss of function of the 5-HT2A receptor alters the degree of neural activation of the paraventricular nucleus (PVN) of the hypothalamus in response to acute Flx, and baseline expression of several IEGs in the PFC in a sexually dimorphic manner.

Phylogenetic relatedness and immediate early gene expression in black-capped chickadees

2012 ◽  
Author(s):  
Christopher B. Sturdy ◽  
Marc T. Avey ◽  
Laurie L. Bloomfield ◽  
Julie E. Elie ◽  
Todd M. Freeberg ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Phylogenetic Relatedness ◽  
Early Gene Expression

scholarly journals Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells

2004 ◽  
Vol 557 (3) ◽  
pp. 773-783 ◽  
Author(s):  
Guoxiang Yuan ◽  
Gautam Adhikary ◽  
Andrew A. McCormick ◽  
John. J. Holcroft ◽  
Ganesh K. Kumar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pc12 Cells ◽  
Intermittent Hypoxia ◽  
Gene Activation ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early

Activation of HIV LTR-directed expression: Analysis with pseudorabies virus immediate early gene

Virology ◽  
1989 ◽  
Vol 172 (1) ◽  
pp. 92-99 ◽  
Author(s):  
R. Yuan ◽  
C. Bohan ◽  
F.C.H. Shiaoj ◽  
R. Robinson ◽  
H.J. Kaplan ◽  
...  
Keyword(s):  
Expression Analysis ◽  
Pseudorabies Virus ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early
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