scholarly journals Genetic inactivation of synaptosomal-associated protein 25 (SNAP-25) in adult hippocampal neural progenitors impairs pattern discrimination learning but not survival or structural maturation of newborn dentate granule cells

Hippocampus ◽  
2018 ◽  
Vol 28 (10) ◽  
pp. 735-744 ◽  
Author(s):  
Kymberly C. Gustus ◽  
Lu Li ◽  
Praveen Chander ◽  
Jason P. Weick ◽  
Michael C. Wilson ◽  
...  
Keyword(s):  
Discrimination Learning ◽  
Granule Cells ◽  
Pattern Discrimination ◽  
Neural Progenitors ◽  
Dentate Granule Cells ◽  
Genetic Inactivation

scholarly journals Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Qingying Tang ◽  
Shuxia Chen ◽  
Hui Wu ◽  
Honghua Song ◽  
Yongjun Wang ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Granule Cells ◽  
Spine Density ◽  
Drug Induced ◽  
Distinct Cell Type ◽  
Cognitive Behaviors ◽  
Dentate Granule Cells ◽  
Rat Pups ◽  
Cognitive Deficiency ◽  
Underlying Mechanisms

AbstractCongenital hypothyroidism (CH), a common neonatal endocrine disorder, can result in cognitive deficits if delay in diagnose and treatment. Dentate gyrus (DG) is the severely affected subregion of the hippocampus by the CH, where the dentate granule cells (DGCs) reside in. However, how CH impairs the cognitive function via affecting DGCs and the underlying mechanisms are not fully elucidated. In the present study, the CH model of rat pups was successfully established, and the aberrant dendrite growth of the DGCs and the impaired cognitive behaviors were observed in the offspring. Transcriptome analysis of hippocampal tissues following rat CH successfully identified that calcium/calmodulin-dependent protein kinase IV (CaMKIV) was the prominent regulator involved in mediating deficient growth of DGC dendrites. CaMKIV was shown to be dynamically regulated in the DG subregion of the rats following drug-induced CH. Interference of CaMKIV expression in the primary DGCs significantly reduced the spine density of dendrites, while addition of T3 to the primary DGCs isolated from CH pups could facilitate the spine growth of dendrites. Insights into relevant mechanisms revealed that CH-mediated CaMKIV deficiency resulted in the significant decrease of phosphorylated CREB in DGCs, in association with the abnormality of dendrites. Our results have provided a distinct cell type in hippocampus that is affected by CH, which would be beneficial for the treatment of CH-induced cognitive deficiency.

scholarly journals Pten Knockdown In Vivo Increases Excitatory Drive onto Dentate Granule Cells

2011 ◽  
Vol 31 (11) ◽  
pp. 4345-4354 ◽  
Author(s):  
B. W. Luikart ◽  
E. Schnell ◽  
E. K. Washburn ◽  
A. L. Bensen ◽  
K. R. Tovar ◽  
...  
Keyword(s):  
Granule Cells ◽  
Dentate Granule Cells ◽  
Excitatory Drive

scholarly journals The type 1 interleukin 1 receptor is not required for the death of murine hippocampal dentate granule cells and microglia activation

2008 ◽  
Vol 1194 ◽  
pp. 8-20 ◽  
Author(s):  
G. Jean Harry ◽  
Jason A. Funk ◽  
Christian Lefebvre d'Hellencourt ◽  
Christopher A. McPherson ◽  
Mineyoshi Aoyama
Keyword(s):  
Granule Cells ◽  
Interleukin 1 ◽  
Microglia Activation ◽  
Dentate Granule Cells
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