Reconsolidation-induced rescue of a remote fear memory blocked by an early cortical inhibition: Involvement of the anterior cingulate cortex and the mediation by the thalamic nucleus reuniens

Hippocampus ◽  
2017 ◽  
Vol 27 (5) ◽  
pp. 596-607 ◽  
Author(s):  
Rodrigo O. Sierra ◽  
Lizeth K. Pedraza ◽  
Querusche K. Zanona ◽  
Fabiana Santana ◽  
Flávia Z. Boos ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Thalamic Nucleus ◽  
Cingulate Cortex ◽  
Fear Memory ◽  
Anterior Cingulate ◽  
Cortical Inhibition ◽  
Nucleus Reuniens

scholarly journals Spine growth in the anterior cingulate cortex is necessary for the consolidation of contextual fear memory

2011 ◽  
Vol 108 (20) ◽  
pp. 8456-8460 ◽  
Author(s):  
G. Vetere ◽  
L. Restivo ◽  
C. J. Cole ◽  
P. J. Ross ◽  
M. Ammassari-Teule ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Fear Memory ◽  
Anterior Cingulate ◽  
Contextual Fear ◽  
Contextual Fear Memory

Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation

2020 ◽  
Vol 168 ◽  
pp. 108028 ◽  
Author(s):  
Ying-Zhi Deng ◽  
Yu-Chen Lu ◽  
Wei-Wei Wu ◽  
Li Cheng ◽  
Gui-Ying Zan ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Thalamic Nucleus ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Itch Sensation

scholarly journals Pavlovian Fear Memory Induced by Activation in the Anterior Cingulate Cortex

2005 ◽  
Vol 1 ◽  
pp. 1744-8069-1-6 ◽  
Author(s):  
Jianrong Tang ◽  
Shanelle Ko ◽  
Hoi-Ki Ding ◽  
Chang-Shen Qiu ◽  
Amelita A Calejesan ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Metabotropic Glutamate Receptors ◽  
Cingulate Cortex ◽  
Fear Memory ◽  
Anterior Cingulate ◽  
Tail Flick ◽  
Direct Stimulation ◽  
Metabotropic Glutamate ◽  
Excitatory Activity

Identifying higher brain central region(s) that are responsible for the unpleasantness of pain is the focus of many recent studies. Here we show that direct stimulation of the anterior cingulate cortex (ACC) in mice produced fear-like freezing responses and induced long-term fear memory, including contextual and auditory fear memory. Auditory fear memory required the activation of N-methyl-D-aspartate (NMDA) receptors in the amygdala. To test the hypothesis that neuronal activity in the ACC contributes to unpleasantness, we injected a GABAA receptor agonist, muscimol bilaterally into the ACC. Both contextual and auditory memories induced by foot shock were blocked. Furthermore, activation of metabotropic glutamate receptors in the ACC enhanced behavioral escape responses in a noxious hot-plate as well as spinal nociceptive tail-flick reflex. Our results provide strong evidence that the excitatory activity in the ACC contribute to pain-related fear memory as well as descending facilitatory modulation of spinal nociception.

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