Mossy fiber sprouting and pyramidal cell dispersion in the hippocampal CA2 region in a mouse model of temporal lobe epilepsy

Hippocampus ◽  
2015 ◽  
Vol 26 (5) ◽  
pp. 577-588 ◽  
Author(s):  
Ute Häussler ◽  
Katrin Rinas ◽  
Antje Kilias ◽  
Ulrich Egert ◽  
Carola A. Haas
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Pyramidal Cell ◽  
Mossy Fiber ◽  
Mossy Fiber Sprouting ◽  
Cell Dispersion

scholarly journals High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy

Epilepsia ◽  
2013 ◽  
Vol 54 (9) ◽  
pp. 1535-1541 ◽  
Author(s):  
Kathleen Heng ◽  
Megan M. Haney ◽  
Paul S. Buckmaster
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Mossy Fiber ◽  
High Dose ◽  
Mossy Fiber Sprouting

scholarly journals Correlations Between Granule Cell Dispersion, Mossy Fiber Sprouting, and Hippocampal Cell Loss in Temporal Lobe Epilepsy

Epilepsia ◽  
1999 ◽  
Vol 40 (10) ◽  
pp. 1393-1401 ◽  
Author(s):  
Bouchaib El Bahh ◽  
Veronique Lespinet ◽  
Dominique Lurton ◽  
Monique Coussemacq ◽  
Gildas Le Gal La Salle ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Granule Cell ◽  
Mossy Fiber ◽  
Cell Loss ◽  
Mossy Fiber Sprouting ◽  
Hippocampal Cell ◽  
Cell Dispersion

Spontaneous Excitatory Currents and κ-Opioid Receptor Inhibition in Dentate Gyrus Are Increased in the Rat Pilocarpine Model of Temporal Lobe Epilepsy

1997 ◽  
Vol 78 (4) ◽  
pp. 1860-1868 ◽  
Author(s):  
Michele L. Simmons ◽  
Gregory W. Terman ◽  
Charles Chavkin
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Opioid Receptor ◽  
Temporal Lobe ◽  
Mossy Fiber ◽  
Perforant Path ◽  
Mossy Fiber Sprouting ◽  
Receptor Inhibition ◽  
Excitatory Activity ◽  
Pilocarpine Model

Simmons, Michele L., Gregory W. Terman, and Charles Chavkin. Spontaneous excitatory currents and κ-opioid receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy. J. Neurophysiol. 78: 1860–1868, 1997. Temporal lobe epilepsy is associated with a characteristic pattern of synaptic reorganization in the hippocampal formation, consisting of neuronal loss and aberrant growth of mossy fiber collaterals into the dentate gyrus inner molecular layer. We have used the rat pilocarpine model of temporal lobe epilepsy to study the functional consequences of mossy fiber sprouting on excitatory activity and κ-opioid receptor-mediated inhibition. Using the whole cell voltage-clamp technique, we found that abnormal excitatory activity was evident in granule cells of the dentate gyrus from pilocarpine-treated rats. The frequency of spontaneous excitatory postsynaptic currents (EPSCs) was increased greatly in cells from tissue in which significant mossy fiber sprouting had developed. In the presence of bicuculline, giant spontaneous EPSCs, with large amplitudes and long durations, were seen only in association with mossy fiber sprouting. Giant EPSCs also could be evoked by low-intensity stimulation of the perforant path. Mossy fibers release not only excitatory amino acids, but also opioid peptides. κ-Opioid receptor-mediated inhibition in normal Sprague-Dawley rats was seen only in hippocampal sections from the ventral pole. In pilocarpine-treated rats, however, kappa receptor-mediated effects were seen in both ventral and more dorsal sections. Thus in this model of temporal lobe epilepsy, several types of abnormal excitatory activity were observed, thereby supporting the idea that mossy fiber sprouting leads to recurrent excitatory connections. At the same time, inhibition of excitatory activity by κ-opioid receptors was increased, perhaps representing an endogenous anticonvulsant mechanism.

Impaired reelin processing and secretion by Cajal-Retzius cells contributes to granule cell dispersion in a mouse model of temporal lobe epilepsy

Hippocampus ◽  
2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Venceslas Duveau ◽  
Amrita Madhusudan ◽  
Matteo Caleo ◽  
Irene Knuesel ◽  
Jean-Marc Fritschy
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Granule Cell ◽  
Cell Dispersion ◽  
Retzius Cells

scholarly journals Association Between the Density of Mossy Fiber Sprouting and Seizure Frequency in Experimental and Human Temporal Lobe Epilepsy

Epilepsia ◽  
2000 ◽  
Vol 41 (s6) ◽  
pp. S24-S29 ◽  
Author(s):  
Asla Pitkanen ◽  
Jari Nissinen ◽  
Katarzyna Lukasiuk ◽  
Leena Jutila ◽  
Leo Paljarvi ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Seizure Frequency ◽  
Mossy Fiber ◽  
Mossy Fiber Sprouting ◽  
Human Temporal Lobe
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