scholarly journals Deficits in hippocampal-dependent transfer generalization learning accompany synaptic dysfunction in a mouse model of amyloidosis

Hippocampus ◽  
2015 ◽  
Vol 26 (4) ◽  
pp. 455-471 ◽  
Author(s):  
Karienn S. Montgomery ◽  
George Edwards ◽  
Yona Levites ◽  
Ashok Kumar ◽  
Catherine E. Myers ◽  
...  
Keyword(s):  
Mouse Model ◽  
Synaptic Dysfunction

scholarly journals Imbalance in the response of pre- and post-synaptic components to amyloidopathy

2019 ◽  
Author(s):  
Terri-Leigh Stephen ◽  
Francesco Tamagnini ◽  
Judith Piegsa ◽  
Katherine Sung ◽  
Joshua Harvey ◽  
...  
Keyword(s):  
Mouse Model ◽  
Synaptic Dysfunction ◽  
Functional Impairments ◽  
Synaptic Terminals ◽  
Diffuse Part ◽  
Initial Area ◽  
Synapse Density ◽  
Synaptic Dynamics ◽  
Underlying Pathology ◽  
Over Time

AbstractAlzheimer’s disease (AD)-associated synaptic dysfunction drives the progression of pathology from its earliest stages. Aβ species, both soluble and in plaque deposits, have been causally related to the progressive, structural and functional impairments observed in AD. It is, however, still unclear how Aβ plaques develop over time and how they progressively affect local synapse density and turnover. Here we observed, in a mouse model of AD, that Aβ plaques grow faster in the earlier stages of the disease and if their initial area is > 500 µm2; this may be due to deposition occurring in the diffuse part of the plaque. In addition, synaptic turnover is higher in the presence of amyloid pathology and this is paralleled by a reduction in pre-but not post-synaptic densities. Plaque proximity does not appear to have an impact on synaptic dynamics. These observations indicate an imbalance in the response of the pre- and post-synaptic terminals and that therapeutics, alongside targeting the underlying pathology, need to address changes in synapse dynamics.

scholarly journals Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease

Aging Cell ◽  
2018 ◽  
Vol 17 (4) ◽  
pp. e12791 ◽  
Author(s):  
David Baglietto-Vargas ◽  
Gilberto Aleph Prieto ◽  
Agenor Limon ◽  
Stefania Forner ◽  
Carlos J. Rodriguez-Ortiz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Synaptic Dysfunction ◽  
Model Of Alzheimer’S Disease

scholarly journals Identifying early markers of synaptic dysfunction in a mouse model of tauopathy

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Soraya Meftah ◽  
Jonathan Witton ◽  
Annalisa Cavallini ◽  
Tracey K. Murray ◽  
Lukasz Jankowski ◽  
...  
Keyword(s):  
Mouse Model ◽  
Synaptic Dysfunction ◽  
Early Markers

P4-052: Dissociation of synaptic dysfunction and behavior in a tauopathy mouse model (PrP-MAPT) of Alzheimer's disease

2009 ◽  
Vol 5 (4S_Part_15) ◽  
pp. P446-P447
Author(s):  
Margaret Zaleska ◽  
Robert A. Crozier ◽  
Nathalie Breysse ◽  
Reka Hosszu ◽  
Mark R. Bowlby ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Synaptic Dysfunction ◽  
And Behavior
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