scholarly journals Physical exercise and acute restraint stress differentially modulate hippocampal brain-derived neurotrophic factor transcripts and epigenetic mechanisms in mice

Hippocampus ◽  
2015 ◽  
Vol 25 (11) ◽  
pp. 1380-1392 ◽  
Author(s):  
Alessandro Ieraci ◽  
Alessandra Mallei ◽  
Laura Musazzi ◽  
Maurizio Popoli
Keyword(s):  
Physical Exercise ◽  
Neurotrophic Factor ◽  
Restraint Stress ◽  
Brain Derived Neurotrophic Factor ◽  
Epigenetic Mechanisms ◽  
Acute Restraint Stress

Physical exercise modulates peripheral levels of brain-derived neurotrophic factor (BDNF): A systematic review of experimental studies in the elderly

2013 ◽  
Vol 56 (1) ◽  
pp. 10-15 ◽  
Author(s):  
Flávia Gomes de Melo Coelho ◽  
Sebastião Gobbi ◽  
Carla Andreza Almeida Andreatto ◽  
Danilla Icassati Corazza ◽  
Renata Valle Pedroso ◽  
...  
Keyword(s):  
Systematic Review ◽  
Physical Exercise ◽  
Neurotrophic Factor ◽  
Experimental Studies ◽  
The Elderly ◽  
Brain Derived Neurotrophic Factor

Social isolation and social support at adulthood affect epigenetic mechanisms, brain-derived neurotrophic factor levels and behavior of chronically stressed rats

2019 ◽  
Vol 366 ◽  
pp. 36-44 ◽  
Author(s):  
Juliano Viana Borges ◽  
Betânia Souza de Freitas ◽  
Vinicius Antoniazzi ◽  
Cristophod de Souza dos Santos ◽  
Kelem Vedovelli ◽  
...  
Keyword(s):  
Social Support ◽  
Social Isolation ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Epigenetic Mechanisms ◽  
And Behavior

scholarly journals Acute increases in brain-derived neurotrophic factor in plasma following physical exercise relates to subsequent learning in older adults

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jonna Nilsson ◽  
Örjan Ekblom ◽  
Maria Ekblom ◽  
Alexander Lebedev ◽  
Olga Tarassova ◽  
...  
Keyword(s):  
Older Adults ◽  
Physical Exercise ◽  
Cognitive Training ◽  
Neurotrophic Factor ◽  
Controlled Trial ◽  
Empirical Support ◽  
Brain Derived Neurotrophic Factor ◽  
Lifestyle Interventions ◽  
Training Outcome ◽  
Subsequent Learning

AbstractMultidomain lifestyle interventions represents a promising strategy to counteract cognitive decline in older age. Brain-derived neurotrophic factor (BDNF) is essential for experience-dependent plasticity and increases following physical exercise, suggesting that physical exercise may facilitate subsequent learning. In a randomized-controlled trial, healthy older adults (65–75 years) completed a 12-week behavioral intervention that involved either physical exercise immediately before cognitive training (n = 25; 13 females), physical exercise immediately after cognitive training (n = 24; 11 females), physical exercise only (n = 27; 15 females), or cognitive training only (n = 21; 12 females). We hypothesized that cognition would benefit more from cognitive training when preceded as opposed to followed by physical exercise and that the relationship between exercise-induced increases in peripheral BDNF and cognitive training outcome would be greater when cognitive training is preceded by physical exercise. Greater increases of plasma BDNF were associated with greater cognitive training gains on trained task paradigms, but only when such increases preceded cognitive training (ß = 0.14, 95% CI [0.04, 0.25]). Average cognitive training outcome did not differ depending on intervention order (ß = 0.05, 95% CI [−0.10, 0.20]). The study provides the first empirical support for a time-critical but advantageous role for post-exercise increases in peripheral BDNF for learning at an interindividual level in older adults, with implications for future multidomain lifestyle interventions.

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