scholarly journals Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss

Hippocampus ◽  
2015 ◽  
Vol 25 (7) ◽  
pp. 813-826 ◽  
Author(s):  
Rahasson R. Ager ◽  
Joy L. Davis ◽  
Andy Agazaryan ◽  
Francisca Benavente ◽  
Wayne W. Poon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Neuronal Loss ◽  
Transgenic Models ◽  
Synaptic Growth ◽  
Human Neural Stem Cells

scholarly journals Sortilin-Related Receptor Expression in Human Neural Stem Cells Derived from Alzheimer’s Disease Patients Carrying the APOE Epsilon 4 Allele

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Alen Zollo ◽  
Zoe Allen ◽  
Helle F. Rasmussen ◽  
Filomena Iannuzzi ◽  
Yichen Shi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
The Elderly ◽  
Receptor Expression ◽  
Human Neural Stem Cells ◽  
Apoe4 Allele

Alzheimer’s disease (AD) is the most common form of dementia in the elderly; important risk factors are old age and inheritance of the apolipoprotein E4 (APOE4) allele. Changes in amyloid precursor protein (APP) binding, trafficking, and sorting may be important AD causative factors. Secretase-mediated APP cleavage produces neurotoxic amyloid-beta (Aβ) peptides, which form lethal deposits in the brain. In vivo and in vitro studies have implicated sortilin-related receptor (SORL1) as an important factor in APP trafficking and processing. Recent in vitro evidence has associated the APOE4 allele and alterations in the SORL1 pathway with AD development and progression. Here, we analyzed SORL1 expression in neural stem cells (NSCs) from AD patients carrying null, one, or two copies of the APOE4 allele. We show reduced SORL1 expression only in NSCs of a patient carrying two copies of APOE4 allele with increased Aβ/SORL1 localization along the degenerated neurites. Interestingly, SORL1 binding to APP was largely compromised; this could be almost completely reversed by γ-secretase (but not β-secretase) inhibitor treatment. These findings may yield new insights into the complex interplay of SORL1 and AD pathology and point to NSCs as a valuable tool to address unsolved AD-related questions in vitro.

scholarly journals Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer's Disease

2016 ◽  
Vol 5 (3) ◽  
pp. 379-391 ◽  
Author(s):  
Lisa M. McGinley ◽  
Erika Sims ◽  
J. Simon Lunn ◽  
Osama N. Kashlan ◽  
Kevin S. Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Growth Factor ◽  
Neural Stem Cells ◽  
Cellular Therapy ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I
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