Repeated stimulation of dopamine D1-like receptor and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits

Hippocampus ◽  
2014 ◽  
Vol 24 (12) ◽  
pp. 1466-1481 ◽  
Author(s):  
Giuseppe Gangarossa ◽  
Laura Ceolin ◽  
Alexia Paucard ◽  
Mireille Lerner-Natoli ◽  
Julie Perroy ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Memory Deficits ◽  
Mtor Signaling ◽  
Repeated Stimulation ◽  
Generalized Seizures ◽  
Stimulation Of

Increase in extracellular dopamine levels during clozapine-induced potentiation in the hippocampal dentate gyrus of chronically prepared rabbits

2008 ◽  
Vol 86 (5) ◽  
pp. 249-256 ◽  
Author(s):  
Takashi Kubota ◽  
Itsuki Jibiki ◽  
Akira Ishikawa ◽  
Tomomi Kawamura ◽  
Sonoko Kurokawa ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Nmda Receptor ◽  
Dentate Gyrus ◽  
Negative Symptoms ◽  
Clinical Effect ◽  
Perforant Path ◽  
Hippocampal Dentate Gyrus ◽  
Extracellular Dopamine ◽  
Stimulation Of ◽  
Synaptic Responses

We previously found that 20 mg/kg clozapine i.p. potentiated the excitatory synaptic responses elicited in the dentate gyrus by single electrical stimulation of the perforant path in chronically prepared rabbits. We called this phenomenon clozapine-induced potentiation and proved that it was an NMDA receptor-mediated event. This potentiation is presumably related to clozapine’s clinical effect on negative symptoms and cognitive dysfunctions in schizophrenia. In the present study, to investigate the mechanisms underlying clozapine-induced potentiation, we examined whether extracellular dopamine and 5-HT levels changed during the potentiation by using a microdialysis technique in the dentate gyrus. The extracellular concentrations of dopamine and 5-HT levels were measured every 5 min during all experiments. Extracellular 5-HT levels did not change, but dopamine levels eventually increased significantly during clozapine-induced potentiation. The increase in the dopamine levels occurred almost simultaneously with the induction of clozapine-induced potentiation. These results suggest that clozapine-induced potentiation is at least partly attributable to a dopamine-mediated potentiation of excitatory synaptic transmission. The present study implies that such phenomena occur also in the perforant path–dentate gyrus pathway.

Complex dynamics resulting from repeated stimulation of nonlinear oscillators at a fixed phase

1987 ◽  
Vol 125 (2-3) ◽  
pp. 119-122 ◽  
Author(s):  
John Lewis ◽  
Manjit Bachoo ◽  
Leon Glass ◽  
Canio Polosa
Keyword(s):  
Complex Dynamics ◽  
Nonlinear Oscillators ◽  
Repeated Stimulation ◽  
Fixed Phase ◽  
Stimulation Of

scholarly journals Repeated Stimulation of CRF Receptors in the BNST of Rats Selectively Induces Social but not Panic-Like Anxiety

2008 ◽  
Vol 33 (11) ◽  
pp. 2586-2594 ◽  
Author(s):  
Younglim Lee ◽  
Stephanie Fitz ◽  
Philip L Johnson ◽  
Anantha Shekhar
Keyword(s):  
Repeated Stimulation ◽  
Stimulation Of
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