Social instability stress in adolescent male rats alters hippocampal neurogenesis and produces deficits in spatial location memory in adulthood

Hippocampus ◽  
2011 ◽  
Vol 22 (6) ◽  
pp. 1300-1312 ◽  
Author(s):  
Cheryl M. McCormick ◽  
Catherine M. Thomas ◽  
Cheryl S. Sheridan ◽  
Feather Nixon ◽  
Jennifer A. Flynn ◽  
...  
Keyword(s):  
Spatial Location ◽  
Hippocampal Neurogenesis ◽  
Male Rats ◽  
Adolescent Male ◽  
Social Instability ◽  
Location Memory

Social instability stress in adolescent male rats reduces social interaction and social recognition performance and increases oxytocin receptor binding

Neuroscience ◽  
2017 ◽  
Vol 359 ◽  
pp. 172-182 ◽  
Author(s):  
Travis E. Hodges ◽  
Jennet L. Baumbach ◽  
Marina L. Marcolin ◽  
Remco Bredewold ◽  
Alexa H. Veenema ◽  
...  
Keyword(s):  
Social Interaction ◽  
Receptor Binding ◽  
Recognition Performance ◽  
Oxytocin Receptor ◽  
Social Recognition ◽  
Male Rats ◽  
Adolescent Male ◽  
Social Instability

scholarly journals Ectopic hippocampal neurogenesis in adolescent male rats following alcohol dependence

2013 ◽  
Vol 19 (4) ◽  
pp. 687-699 ◽  
Author(s):  
Justin A. McClain ◽  
Stephanie A. Morris ◽  
S. Alexander Marshall ◽  
Kimberly Nixon
Keyword(s):  
Alcohol Dependence ◽  
Hippocampal Neurogenesis ◽  
Male Rats ◽  
Adolescent Male

Predictors of social instability stress effects on social interaction and anxiety in adolescent male rats

2018 ◽  
Vol 60 (6) ◽  
pp. 651-663 ◽  
Author(s):  
Travis E. Hodges ◽  
Jennet L. Baumbach ◽  
Cheryl M. McCormick
Keyword(s):  
Social Interaction ◽  
Male Rats ◽  
Adolescent Male ◽  
Social Instability ◽  
Stress Effects

scholarly journals Adolescent male rats exposed to social defeat exhibit altered anxiety behavior and limbic monoamines as adults.

2009 ◽  
Vol 123 (3) ◽  
pp. 564-576 ◽  
Author(s):  
Michael J. Watt ◽  
Andrew R. Burke ◽  
Kenneth J. Renner ◽  
Gina L. Forster
Keyword(s):  
Social Defeat ◽  
Male Rats ◽  
Adolescent Male ◽  
Anxiety Behavior

scholarly journals Discordant Effects of Cannabinoid 2 Receptor Antagonism/Inverse Agonism During Adolescence on Pavlovian and Instrumental Reward Learning in Adult Male Rats

2021 ◽  
Vol 13 ◽  
Author(s):  
Danna Ellner ◽  
Bryana Hallam ◽  
Jude A. Frie ◽  
Hayley H. A. Thorpe ◽  
Muhammad Shoaib ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Critical Role ◽  
Behavioral Outcomes ◽  
Endocannabinoid System ◽  
Developmental Trajectory ◽  
Male Rats ◽  
Reward Learning ◽  
Adolescent Male ◽  
High Dose ◽  
Lever Pressing

The endocannabinoid system is responsible for regulating a spectrum of physiological activities and plays a critical role in the developing brain. During adolescence, the endocannabinoid system is particularly sensitive to external insults that may change the brain’s developmental trajectory. Cannabinoid receptor type 2 (CB2R) was initially thought to predominantly function in the peripheral nervous system, but more recent studies have implicated its role in the mesolimbic pathway, a network largely attributed to reward circuitry and reward motivated behavior, which undergoes extensive changes during adolescence. It is therefore important to understand how CB2R modulation during adolescence can impact reward-related behaviors in adulthood. In this study, adolescent male rats (postnatal days 28–41) were exposed to a low or high dose of the CB2R antagonist/inverse agonist SR144528 and Pavlovian autoshaping and instrumental conditional behavioral outcomes were measured in adulthood. SR144528-treated rats had significantly slower acquisition of the autoshaping task, seen by less lever pressing behavior over time [F(2, 19) = 5.964, p = 0.010]. Conversely, there was no effect of adolescent SR144528 exposure on instrumental conditioning. These results suggest that modulation of the CB2R in adolescence differentially impacts reward-learning behaviors in adulthood.

Nicotine-induced impairments of spatial cognition and long-term potentiation in adolescent male rats

2013 ◽  
Vol 33 (2) ◽  
pp. 203-213 ◽  
Author(s):  
G Han ◽  
L An ◽  
B Yang ◽  
L Si ◽  
T Zhang
Keyword(s):  
Young Adult ◽  
Learning And Memory ◽  
Long Term Potentiation ◽  
Male Rats ◽  
Adolescent Male ◽  
Control Group ◽  
Adult Offspring ◽  
Behavioral Impairment ◽  
Term Potentiation

The aim of the present study was to investigate whether cognitive behavioral impairment, induced by nicotine in offspring rats, was associated with the alteration of hippocampal short-term potentiation (STP) and long-term potentiation (LTP) and to discuss the potential underlying mechanism. Young adult offspring rats were randomly divided into three groups. The groups include: control group (CC), nicotine group 1 (NC), in which their mothers received nicotine from gestational day 3 (GD3) to GD18, and nicotine group 2 (CN), in which young adult offspring rats received nicotine from postnatal day 42 (PD42) to PD56. Morris water maze (MWM) test was performed and then field excitatory postsynaptic potentials elicited by the stimulation of perforant pathway were recorded in the hippocampal dentate gyrus region. The results of the MWM test showed that learning and memory were impaired by either prenatal or postnatal nicotine exposure. In addition, it was found that there was no statistical difference of the MWM data between both nicotine treatments. In the electrophysiological test, LTP and STP were significantly inhibited in both NC and CN groups in comparison with the CC group. Notably, STP in CN group was also lower than that in the NC group. These findings suggested that both prenatal and postnatal exposure to nicotine induced learning and memory deficits, while the potential mechanism might be different from each other due to their dissimilar impairments of synaptic plasticity.

Choline chloride modulates learning, memory, and synaptic plasticity impairments in maternally separated adolescent male rats

2021 ◽  
Author(s):  
Sarieh Shahraki ◽  
Khadijeh Esmaeilpour ◽  
Mohammad Shabani ◽  
Gholamreza Sepehri ◽  
Mohammad Amin Rajizadeh ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Choline Chloride ◽  
Male Rats ◽  
Adolescent Male

scholarly journals Effects of long‐term paroxetine or bupropion treatment on puberty onset, reproductive and feeding parameters in adolescent male rats

Andrologia ◽  
2019 ◽  
Vol 51 (6) ◽  
pp. e13268 ◽  
Author(s):  
Ahmet Yardimci ◽  
Nazife Ulker ◽  
Ozgur Bulmus ◽  
Nalan Kaya ◽  
Neriman Colakoglu ◽  
...  
Keyword(s):  
Male Rats ◽  
Adolescent Male ◽  
Feeding Parameters ◽  
Puberty Onset

Repeated exposure to chlorpyrifos alters the performance of adolescent male rats in animal models of depression and anxiety

2011 ◽  
Vol 32 (4) ◽  
pp. 355-361 ◽  
Author(s):  
Wen-Qiang Chen ◽  
Li Yuan ◽  
Rui Xue ◽  
Yun-Feng Li ◽  
Rui-Bin Su ◽  
...  
Keyword(s):  
Animal Models ◽  
Repeated Exposure ◽  
Male Rats ◽  
Adolescent Male ◽  
Depression And Anxiety ◽  
Animal Models Of Depression
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