scholarly journals Glutamate decarboxylase67 is expressed in hippocampal mossy fibers of temporal lobe epilepsy patients

Hippocampus ◽  
2011 ◽  
Vol 22 (3) ◽  
pp. 590-603 ◽  
Author(s):  
Günther Sperk ◽  
Anna Wieselthaler-Hölzl ◽  
Susanne Pirker ◽  
Ramon Tasan ◽  
Sarah S. Strasser ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Mossy Fibers

scholarly journals Aberrant hippocampal mossy fibers in temporal lobe epilepsy target excitatory and inhibitory neurons

Epilepsia ◽  
2021 ◽  
Author(s):  
Barbara Puhahn‐Schmeiser ◽  
Kathrin Leicht ◽  
Florian Gessler ◽  
Thomas M. Freiman
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Mossy Fibers ◽  
Inhibitory Neurons

scholarly journals Early detonation by sprouted mossy fibers enables aberrant dentate network activity

2018 ◽  
Author(s):  
William D. Hendricks ◽  
Gary L. Westbrook ◽  
Eric Schnell
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Probability ◽  
Granule Cells ◽  
Mossy Fiber ◽  
Glutamate Release ◽  
Mossy Fibers ◽  
Network Activity ◽  
Short Term ◽  
Dentate Granule Cells

AbstractIn temporal lobe epilepsy, sprouting of hippocampal mossy fiber axons onto dentate granule cell dendrites creates a recurrent excitatory network. However, unlike mossy fibers projecting to CA3, sprouted mossy fiber synapses depress upon repetitive activation. Thus, despite their proximal location, large presynaptic terminals, and ability to excite target neurons, the impact of sprouted mossy fiber synapses on hippocampal hyperexcitability is unclear. We find that despite their short-term depression, single episodes of sprouted mossy fiber activation in hippocampal slices initiated bursts of recurrent polysynaptic excitation. Consistent with a contribution to network hyperexcitability, optogenetic activation of sprouted mossy fibers reliably triggered action potential firing in postsynaptic dentate granule cells after single light pulses. This pattern resulted in a shift in network recruitment dynamics to an “early detonation” mode and an increased probability of release compared to mossy fiber synapses in CA3. A lack of tonic adenosine-mediated inhibition contributed to the higher probability of glutamate release thus facilitating reverberant circuit activity.Significance StatementSprouted mossy fibers are one of the hallmark histopathological findings in temporal lobe epilepsy. These fibers form recurrent excitatory synapses onto other dentate granule cells that display profound short-term depression. Here, however, we show that although these sprouted mossy fibers weaken substantially during repetitive activation, their initial high probability of glutamate release can activate reverberant network activity. Furthermore, we find that a lack of tonic adenosine inhibition enables this high probability of release and, consequently, recurrent network activity.

Neuropeptide Y biosynthesis is markedly induced in mossy fibers during temporal lobe epilepsy of the rat

1990 ◽  
Vol 112 (2-3) ◽  
pp. 143-148 ◽  
Author(s):  
Josef Marksteiner ◽  
Martin Ortler ◽  
Romuald Bellmann ◽  
Günther Sperk
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Neuropeptide Y ◽  
Temporal Lobe ◽  
Mossy Fibers

Theory of mind and social competence in children and adolescents with temporal lobe epilepsy.

2019 ◽  
Vol 33 (7) ◽  
pp. 986-995 ◽  
Author(s):  
Elizabeth Stewart ◽  
Cathy Catroppa ◽  
Linda Gonzalez ◽  
Deepak Gill ◽  
Richard Webster ◽  
...  
Keyword(s):  
Theory Of Mind ◽  
Social Competence ◽  
Temporal Lobe Epilepsy ◽  
Children And Adolescents ◽  
Temporal Lobe

Decreased Dopamine D2/D3-Receptor Binding in the Temporal Lobe and the Bilateral Basal Ganglia in patients with Temporal Lobe Epilepsy

2012 ◽  
Vol 43 (01) ◽  
Author(s):  
VE Bernedo Paredes ◽  
H Schwartz ◽  
M Gartenschläger ◽  
M Gartenschläger ◽  
HG Buchholz ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Receptor Binding ◽  
D3 Receptor ◽  
Dopamine D2

PSYCHIATRIC CO-MORBIDITY IN PEDIATRIC SURGICALLY TREATED TEMPORAL LOBE EPILEPSY

2006 ◽  
Vol 37 (S 1) ◽  
Author(s):  
C Waisburg ◽  
E Sherman ◽  
L Byron ◽  
A Chapman ◽  
G Ainsworth ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Co Morbidity

Developmental progress in paediatric temporal lobe epilepsy

2006 ◽  
Vol 37 (03) ◽  
Author(s):  
IEB Tuxhorn ◽  
H Freitag ◽  
C Krahn-Peper ◽  
F Behne ◽  
H Pannek ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Developmental Progress

White matter changes in post-surgical temporal lobe epilepsy

2008 ◽  
Vol 39 (01) ◽  
Author(s):  
JC Schoene-Bake ◽  
J Faber ◽  
CE Elger ◽  
B Weber
Keyword(s):  
White Matter ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
White Matter Changes
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