Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF downregulation

Hippocampus ◽  
2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Francisco J. Gil-Bea ◽  
Maite Solas ◽  
Laura Mateos ◽  
Bengt Winblad ◽  
María J. Ramírez ◽  
...  
Keyword(s):  
Memory Acquisition ◽  
Cholinergic Hypofunction

scholarly journals Pharmacological rescue of cognitive function in a mouse model of chemobrain

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Lien D. Nguyen ◽  
Tom T. Fischer ◽  
Barbara E. Ehrlich
Keyword(s):  
Cognitive Impairment ◽  
Prefrontal Cortex ◽  
Calcium Oscillations ◽  
Neuronal Morphology ◽  
Post Injection ◽  
Object Recognition Test ◽  
Cognitive Changes ◽  
Memory Acquisition ◽  
Underlying Mechanisms ◽  
Trisphosphate Receptor

Abstract Background After chemotherapy, many cancer survivors suffer from long-lasting cognitive impairment, colloquially known as “chemobrain.” However, the trajectories of cognitive changes and the underlying mechanisms remain unclear. We previously established paclitaxel-induced inositol trisphosphate receptor (InsP3R)-dependent calcium oscillations as a mechanism for peripheral neuropathy, which was prevented by lithium pretreatment. Here, we investigated if a similar mechanism also underlay paclitaxel-induced chemobrain. Method Mice were injected with 4 doses of 20 mg/kg paclitaxel every other day to induced cognitive impairment. Memory acquisition was assessed with the displaced object recognition test. The morphology of neurons in the prefrontal cortex and the hippocampus was analyzed using Golgi-Cox staining, followed by Sholl analyses. Changes in protein expression were measured by Western blot. Results Mice receiving paclitaxel showed impaired short-term spatial memory acquisition both acutely 5 days post injection and chronically 23 days post injection. Dendritic length and complexity were reduced in the hippocampus and the prefrontal cortex after paclitaxel injection. Concurrently, the expression of protein kinase C α (PKCα), an effector in the InsP3R pathway, was increased. Treatment with lithium before or shortly after paclitaxel injection rescued the behavioral, cellular, and molecular deficits observed. Similarly, memory and morphological deficits could be rescued by pretreatment with chelerythrine, a PKC inhibitor. Conclusion We establish the InsP3R calcium pathway and impaired neuronal morphology as mechanisms for paclitaxel-induced cognitive impairment. Our findings suggest lithium and PKC inhibitors as candidate agents for preventing chemotherapy-induced cognitive impairment.

Prefrontal cortex nicotinic receptor inhibition by methyllycaconitine impaired cocaine-associated memory acquisition and retrieval

2021 ◽  
pp. 113212
Author(s):  
Verónica Pastor ◽  
Fernando Castillo Díaz ◽  
Valeria C. Sanabria ◽  
Juliana F. Dalto ◽  
Marta C. Antonelli ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nicotinic Receptor ◽  
Receptor Inhibition ◽  
Memory Acquisition

Why does anti-inflammatory cytokine levels increase during memory acquisition?

Neuroscience ◽  
2021 ◽  
Author(s):  
Sergei G. Levin ◽  
Ekaterina V. Pershina ◽  
Nickolay A. Bugaev-Makarovskiy ◽  
Irina Yu. Chernomorets ◽  
Maxim V. Konakov ◽  
...  
Keyword(s):  
Inflammatory Cytokine ◽  
Cytokine Levels ◽  
Memory Acquisition ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

scholarly journals Evaluating atomicity, and integrity of correct memory acquisition methods

2016 ◽  
Vol 16 ◽  
pp. S1-S10 ◽  
Author(s):  
Michael Gruhn ◽  
Felix C. Freiling
Keyword(s):  
Memory Acquisition

Involvement of opioidergic and nitrergic systems in memory acquisition and exploratory behaviors in cholestatic mice

2013 ◽  
Vol 24 (3) ◽  
pp. 180-194 ◽  
Author(s):  
Mohammad Nasehi ◽  
Morteza Piri ◽  
Kobra Abbolhasani ◽  
Mohammad R. Zarrindast
Keyword(s):  
Memory Acquisition

Hypervisor memory acquisition for ARM

2021 ◽  
Vol 37 ◽  
pp. 301106
Author(s):  
Raz Ben Yehuda ◽  
Erez Shlingbaum ◽  
Yuval Gershfeld ◽  
Shaked Tayouri ◽  
Nezer Jacob Zaidenberg
Keyword(s):  
Memory Acquisition

Integrity and Fidelity Evaluation of Digital Evidence in Live Forensics

2014 ◽  
Vol 571-572 ◽  
pp. 90-99
Author(s):  
Lian Hai Wang ◽  
Qiu Liang Xu
Keyword(s):  
Experimental Error ◽  
Good Accuracy ◽  
Digital Evidence ◽  
System Error ◽  
Accuracy And Precision ◽  
Novel Method ◽  
Memory Acquisition ◽  
Measure Error ◽  
Live Forensics

The integrity and fidelity of digital evidence are very important in live forensics. Previous research has studied the uncertainty of live forensics based on different memory snapshots. However, this kind of method is not effective in practice. In fact, memory images are usually acquired by using forensics tools instead of using snapshots. Therefore, the integrity and fidelity of live evidence should be evaluated during the acquisition process. In this paper, we give a new viewpoint that memory acquisition can be regarded as a measurement of memory data. From this viewpoint, we evaluate the integrity and fidelity of live evidence in the process of physical memory acquisition. Firstly, several definitions about memory acquisition measure error are introduced to describe the trusty. Then, we analyze the experimental error and propose some suggestions on how to reduce it. A novel method is also developed to calculate the system error in detail. The results of a case study on Windows 7 and VMware virtual machine show that the experimental error has good accuracy and precision, which demonstrate the efficacy of the proposed reducing methods. The system error is also evaluated, that is, it accounts for the whole error from 30% to 50%. Last, a method is proposed to calculate changes or error of system process.

scholarly journals Alteraciones de memoria en daño cerebral

2012 ◽  
Vol 4 (3) ◽  
pp. 73
Author(s):  
David De Noreña ◽  
Irene De la Vega Rodríguez
Keyword(s):  
Free Recall ◽  
Frontal Cortex ◽  
Medial Temporal Lobe ◽  
Anterograde Amnesia ◽  
Memory Encoding ◽  
Specific Group ◽  
Memory Impairments ◽  
Strategic Processes ◽  
Memory Acquisition ◽  
Per Se

Frontal cortex is involved in important memory processes but its role is different from that associated with structures in the medial temporal lobe and diencephalon. While damage in the latter structures produces profound and global anterograde amnesia, damage to the frontal cortex is manifested by an specific group of memory impairments and distortions like confabulations, source amnesia, prospective memory and metamemory deficit, or impaired free recall. Frontal lobes is less involved in memory acquisition per se than it is in leading the strategic processes that support memory encoding, retrieval and monitoring.

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