Dentate gyrus and hilus transection blocks seizure propagation and granule cell dispersion in a mouse model for mesial temporal lobe epilepsy

Hippocampus ◽  
2011 ◽  
Vol 21 (3) ◽  
pp. 334-343 ◽  
Author(s):  
Johan Pallud ◽  
Ute Häussler ◽  
Mélanie Langlois ◽  
Sophie Hamelin ◽  
Bertrand Devaux ◽  
...  
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Temporal Lobe ◽  
Granule Cell ◽  
Mesial Temporal Lobe Epilepsy ◽  
Cell Dispersion ◽  
Mesial Temporal Lobe ◽  
Seizure Propagation

scholarly journals Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy

Seizure ◽  
2012 ◽  
Vol 21 (9) ◽  
pp. 685-690 ◽  
Author(s):  
Rafael Scarpa da Costa Neves ◽  
Ivanda de Souza Silva Tudesco ◽  
Anaclara Prada Jardim ◽  
Luís Otávio Sales Ferreira Caboclo ◽  
Carmen Lancellotti ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Granule Cell ◽  
Memory Impairment ◽  
Mesial Temporal Lobe Epilepsy ◽  
Cell Dispersion ◽  
Mesial Temporal Lobe ◽  
With Memory

Survival of mossy cells of the hippocampal dentate gyrus in humans with mesial temporal lobe epilepsy

2009 ◽  
Vol 111 (6) ◽  
pp. 1237-1247 ◽  
Author(s):  
László Seress ◽  
Hajnalka Ábrahám ◽  
Zsolt Horváth ◽  
Tamás Dóczi ◽  
József Janszky ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Temporal Lobe ◽  
Pyramidal Neurons ◽  
Hippocampal Sclerosis ◽  
Mesial Temporal Lobe Epilepsy ◽  
Drug Resistant ◽  
Hippocampal Dentate Gyrus ◽  
Mossy Cells ◽  
Mesial Temporal Lobe

Object Hippocampal sclerosis can be identified in most patients with mesial temporal lobe epilepsy (TLE). Surgical removal of the sclerotic hippocampus is widely performed to treat patients with drug-resistant mesial TLE. In general, both epilepsy-prone and epilepsy-resistant neurons are believed to be in the hippocampal formation. The hilar mossy cells of the hippocampal dentate gyrus are usually considered one of the most vulnerable types of neurons. The aim of this study was to clarify the fate of mossy cells in the hippocampus in epileptic humans. Methods Of the 19 patients included in this study, 15 underwent temporal lobe resection because of drug-resistant TLE. Four patients were used as controls because they harbored tumors that had not invaded the hippocampus and they had experienced no seizures. Histological evaluation of resected hippocampal tissues was performed using immunohistochemistry. Results Mossy cells were identified in the control as well as the epileptic hippocampi by using cocaine- and amphetamine-regulated transcript peptide immunohistochemistry. In most cases the number of mossy cells was reduced and thorny excrescences were smaller in the epileptic hippocampi than in controls; however, there was a significant loss of pyramidal cells and a partial loss of granule cells in the same epileptic hippocampi in which mossy cell loss was apparent. The loss of mossy cells could be correlated with the extent of hippocampal sclerosis, patient age at seizure onset, duration of epilepsy, and frequency of seizures. Conclusions In many cases large numbers of mossy cells were present in the hilus of the dentate gyrus when most pyramidal neurons of the CA1 and CA3 areas of the Ammon's horn were lost, suggesting that mossy cells may not be more vulnerable to epileptic seizures than the hippocampal pyramidal neurons.

Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy

2011 ◽  
Vol 42 (1) ◽  
pp. 35-47 ◽  
Author(s):  
Christophe Heinrich ◽  
Sari Lähteinen ◽  
Fumio Suzuki ◽  
Laharie Anne-Marie ◽  
Susanne Huber ◽  
...  
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Mesial Temporal Lobe Epilepsy ◽  
Mesial Temporal Lobe

scholarly journals Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy

2021 ◽  
Author(s):  
Célia Lentini ◽  
Marie d’Orange ◽  
Nicolás Marichal ◽  
Marie-Madeleine Trottmann ◽  
Rory Vignoles ◽  
...  
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Seizure Activity ◽  
Mesial Temporal Lobe Epilepsy ◽  
Reactive Glia ◽  
Mesial Temporal Lobe

Impaired reelin processing and secretion by Cajal-Retzius cells contributes to granule cell dispersion in a mouse model of temporal lobe epilepsy

Hippocampus ◽  
2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Venceslas Duveau ◽  
Amrita Madhusudan ◽  
Matteo Caleo ◽  
Irene Knuesel ◽  
Jean-Marc Fritschy
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Granule Cell ◽  
Cell Dispersion ◽  
Retzius Cells

scholarly journals Impaired hippocampal rhythmogenesis in a mouse model of mesial temporal lobe epilepsy

2007 ◽  
Vol 104 (44) ◽  
pp. 17530-17535 ◽  
Author(s):  
T. Dugladze ◽  
I. Vida ◽  
A. B. Tort ◽  
A. Gross ◽  
J. Otahal ◽  
...  
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Mesial Temporal Lobe Epilepsy ◽  
Mesial Temporal Lobe
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