Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation

Hippocampus ◽  
2009 ◽  
Vol 19 (9) ◽  
pp. 844-854 ◽  
Author(s):  
Shigeki Moriguchi ◽  
Norifumi Shioda ◽  
Feng Han ◽  
Jay Z. Yeh ◽  
Toshio Narahashi ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Long Term Potentiation ◽  
Dependent Protein Kinase ◽  
Calcium Calmodulin Dependent ◽  
Kinase C ◽  
Term Potentiation ◽  
Dependent Protein ◽  
Protein Kinase C Activation

AMPA receptor phosphorylation during synaptic plasticity

2005 ◽  
Vol 33 (6) ◽  
pp. 1354-1356 ◽  
Author(s):  
J. Boehm ◽  
R. Malinow
Keyword(s):  
Protein Kinase ◽  
Long Term Potentiation ◽  
Synaptic Activity ◽  
Dependent Protein Kinase ◽  
Enhanced Transmission ◽  
Calcium Calmodulin Dependent ◽  
Term Potentiation ◽  
Dependent Protein ◽  
Biochemical Analyses

A widely studied example of vertebrate plasticity is LTP (long-term potentiation), the persistent synaptic enhancement that follows a brief period of coinciding pre- and post-synaptic activity. During LTP, different kinases, including CaMKII (calcium/calmodulin-dependent protein kinase II) and protein kinase A, become activated and play critical roles in induction and maintenance of enhanced transmission. Biochemical analyses have revealed several regulated phosphorylation sites in the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor subunits, GluR1 and GluR4. The regulated insertion of these receptors is a key event in the induction of LTP. Here, we discuss the phosphorylation of GluR1 and GluR4 and its role in receptor delivery and neuronal plasticity.

scholarly journals A Role for Superoxide in Protein Kinase C Activation and Induction of Long-term Potentiation

1998 ◽  
Vol 273 (8) ◽  
pp. 4516-4522 ◽  
Author(s):  
Eric Klann ◽  
Erik D. Roberson ◽  
Lauren T. Knapp ◽  
J. David Sweatt
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Long Term Potentiation ◽  
Kinase C ◽  
Term Potentiation ◽  
Protein Kinase C Activation
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