scholarly journals Towards a functional organization of the medial temporal lobe memory system: Role of the parahippocampal and medial entorhinal cortical areas

Hippocampus ◽  
2008 ◽  
Vol 18 (12) ◽  
pp. 1314-1324 ◽  
Author(s):  
Howard Eichenbaum ◽  
Paul A. Lipton
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Functional Organization ◽  
Memory System ◽  
Cortical Areas

scholarly journals Against memory systems

2002 ◽  
Vol 357 (1424) ◽  
pp. 1111-1121 ◽  
Author(s):  
David Gaffan
Keyword(s):  
Temporal Lobe ◽  
Cortical Neurons ◽  
Medial Temporal Lobe ◽  
Temporal Cortex ◽  
Memory Systems ◽  
Memory System ◽  
Memory Processing ◽  
Multiple Memory Systems ◽  
Cortical Areas ◽  
Severe Impairment

The medial temporal lobe is indispensable for normal memory processing in both human and non–human primates, as is shown by the fact that large lesions in it produce a severe impairment in the acquisition of new memories. The widely accepted inference from this observation is that the medial temporal cortex, including the hippocampal, entorhinal and perirhinal cortex, contains a memory system or multiple memory systems, which are specialized for the acquisition and storage of memories. Nevertheless, there are some strong arguments against this idea: medial temporal lesions produce amnesia by disconnecting the entire temporal cortex from neuromodulatory afferents arising in the brainstem and basal forebrain, not by removing cortex; the temporal cortex is essential for perception as well as for memory; and response properties of temporal cortical neurons make it impossible that some kinds of memory trace could be stored in the temporal lobe. All cortex is plastic, and it is possible that the same rules of plasticity apply to all cortical areas; therefore, memory traces are stored in widespread cortical areas rather than in a specialized memory system restricted to the temporal lobe. Among these areas, the prefrontal cortex has an important role in learning and memory, but is best understood as an area with no specialization of function.

scholarly journals Functional organization of the medial temporal lobe memory system following neonatal hippocampal lesion in rhesus monkeys

2017 ◽  
Vol 222 (9) ◽  
pp. 3899-3914 ◽  
Author(s):  
Loïc J. Chareyron ◽  
Pamela Banta Lavenex ◽  
David G. Amaral ◽  
Pierre Lavenex
Keyword(s):  
Temporal Lobe ◽  
Hippocampal Lesion ◽  
Rhesus Monkeys ◽  
Medial Temporal Lobe ◽  
Functional Organization ◽  
Memory System

scholarly journals The Role of Frontal Cortical and Medial-Temporal Lobe Brain Areas in Learning a Bayesian Prior Belief on Reversals

2015 ◽  
Vol 35 (33) ◽  
pp. 11751-11760 ◽  
Author(s):  
Anthony I. Jang ◽  
Vincent D. Costa ◽  
Peter H. Rudebeck ◽  
Yogita Chudasama ◽  
Elisabeth A. Murray ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Prior Belief ◽  
Brain Areas ◽  
Bayesian Prior

A8 THE ROLE OF HMPAO IMAGING OF THE PRECUNEUS AND MEDIAL TEMPORAL LOBE IN SUSPECTED ALZHEIMER??S DISEASE

2005 ◽  
Vol 26 (3) ◽  
pp. 273
Author(s):  
P.M. Kemp ◽  
S.M.A. Hoffmann ◽  
C. Holmes ◽  
A. Ward ◽  
L. Bolt ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe

scholarly journals Distinct Cortical Anatomy Linked to Subregions of the Medial Temporal Lobe Revealed by Intrinsic Functional Connectivity

2008 ◽  
Vol 100 (1) ◽  
pp. 129-139 ◽  
Author(s):  
Itamar Kahn ◽  
Jessica R. Andrews-Hanna ◽  
Justin L. Vincent ◽  
Abraham Z. Snyder ◽  
Randy L. Buckner
Keyword(s):  
Functional Connectivity ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Temporal Cortex ◽  
Memory System ◽  
Retrosplenial Cortex ◽  
The Body ◽  
Parallel Pathways ◽  
Ventral Medial Prefrontal Cortex ◽  
Adjacent Structures

The hippocampus and adjacent cortical structures in the medial temporal lobe (MTL) contribute to memory through interactions with distributed brain areas. Studies of monkey and rodent anatomy suggest that parallel pathways converge on distinct subregions of the MTL. To explore the cortical areas linked to subregions of the MTL in humans, we examined cortico-cortical and hippocampal-cortical correlations using high-resolution, functional connectivity analysis in 100 individuals. MTL seed regions extended along the anterior to posterior axis and included hippocampus and adjacent structures. Results revealed two separate brain pathways that correlated with distinct subregions within the MTL. The body of the hippocampus and posterior parahippocampal cortex correlated with lateral parietal cortex, regions along the posterior midline including posterior cingulate and retrosplenial cortex, and ventral medial prefrontal cortex. By contrast, anterior hippocampus and the perirhinal/entorhinal cortices correlated with distinct regions in the lateral temporal cortex extending into the temporal pole. The present results are largely consistent with known connectivity in the monkey and provide a novel task-independent dissociation of the parallel pathways supporting the MTL memory system in humans. The cortical pathways include regions that have undergone considerable areal expansion in humans, providing insight into how the MTL memory system has evolved to support a diverse array of cognitive domains.

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