Improved learning and memory of contextual fear conditioning and hippocampal CA1 long-term potentiation in histidine decarboxylase knock-out mice

Hippocampus ◽  
2007 ◽  
Vol 17 (8) ◽  
pp. 634-641 ◽  
Author(s):  
Luying Liu ◽  
Shihong Zhang ◽  
Yongping Zhu ◽  
Qiuli Fu ◽  
Yuanyuan Zhu ◽  
...  
Keyword(s):  
Histidine Decarboxylase ◽  
Long Term Potentiation ◽  
Contextual Fear Conditioning ◽  
Knock Out ◽  
Contextual Fear ◽  
Term Potentiation ◽  
Hippocampal Ca1 ◽  
Improved Learning ◽  
Knock Out Mice

scholarly journals Long-term depression is independent of GluN2 subunit composition

2018 ◽  
Author(s):  
Jonathan M. Wong ◽  
John A. Gray
Keyword(s):  
Long Term Potentiation ◽  
Subunit Composition ◽  
Long Term Depression ◽  
Major Question ◽  
Knock Out ◽  
Single Receptor ◽  
Term Potentiation ◽  
Nmdar Subunit ◽  
Knock Out Mice

AbstractNMDA receptors (NMDARs) mediate major forms of both long-term potentiation (LTP) and long-term depression (LTD) and understanding how a single receptor can initiate both phenomena remains a major question in neuroscience. A prominent hypothesis implicates the NMDAR subunit composition, specifically GluN2A and GluN2B, in dictating the rules of synaptic plasticity. However, studies testing this hypotheses have yielded inconsistent and often contradictory results, especially for LTD. These inconsistent results may be due to challenges in the interpretation of subunit-selective pharmacology and in dissecting out the contributions of differential channel properties versus the interacting proteins unique to GluN2A or GluN2B. In this study, we address the pharmacological and biochemical challenges by utilizing a single-neuron genetic approach to delete NMDAR subunits in both male and female conditional knock-out mice. In addition, emerging evidence that non-ionotropic signaling through the NMDAR is sufficient for NMDAR-dependent LTD allowed the rigorous assessment of unique subunit contributions to NMDAR-dependent LTD while eliminating the variable of differential charge transfer. Here we find that neither the GluN2A nor the GluN2B subunit is strictly necessary for either non-ionotropic or ionotropic LTD.

Long-term potentiation and contextual fear conditioning increase neuronal glutamate uptake

10.1038/nn791 ◽  
2002 ◽  
Vol 5 (2) ◽  
pp. 155-161 ◽  
Author(s):  
Jonathan Levenson ◽  
Edwin Weeber ◽  
Joel C. Selcher ◽  
Lorna S. Kategaya ◽  
J. David Sweatt ◽  
...  
Keyword(s):  
Fear Conditioning ◽  
Glutamate Uptake ◽  
Long Term Potentiation ◽  
Contextual Fear Conditioning ◽  
Contextual Fear ◽  
Term Potentiation

scholarly journals Impaired Conditioned Fear and Enhanced Long-Term Potentiation inFmr2 Knock-Out Mice

2002 ◽  
Vol 22 (7) ◽  
pp. 2753-2763 ◽  
Author(s):  
Yanghong Gu ◽  
Kellie L. McIlwain ◽  
Edwin J. Weeber ◽  
Takanori Yamagata ◽  
Bisong Xu ◽  
...  
Keyword(s):  
Conditioned Fear ◽  
Long Term Potentiation ◽  
Knock Out ◽  
Term Potentiation ◽  
Knock Out Mice
Sign in / Sign up

Export Citation Format

Share Document