Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress-induced decrease in cell proliferation and BDNF expression in rat hippocampus

Hippocampus ◽  
2006 ◽  
Vol 16 (6) ◽  
pp. 551-559 ◽  
Author(s):  
Haiyun Xu ◽  
Zhong Chen ◽  
Jue He ◽  
Samson Haimanot ◽  
Xiaokun Li ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Restraint Stress ◽  
Rat Hippocampus ◽  
Chronic Restraint Stress ◽  
Bdnf Expression ◽  
Synergetic Effects

scholarly journals Mustard Leaf Extract Suppresses Psychological Stress in Chronic Restraint Stress-Subjected Mice by Regulation of Stress Hormone, Neurotransmitters, and Apoptosis

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3640
Author(s):  
Kyung-A. Hwang ◽  
Hye-Jeong Hwang ◽  
Yu Jin Hwang ◽  
Young Jun Kim
Keyword(s):  
Restraint Stress ◽  
Leaf Extract ◽  
Caspase 3 ◽  
Chronic Restraint Stress ◽  
Stress Hormone ◽  
Induce Stress ◽  
Bdnf Expression ◽  
Stress Effects ◽  
Cytokine Levels ◽  
The Brain

Mustard leaf (Brassica juncea var. crispifolia L. H. Bailey) has been reported to have psychological properties such as anti-depressant activities. However, studies on chronic stress and depression caused by restraint have not been conducted. Therefore, this study aimed to evaluate the effects of a mustard leaf (ML) extract on chronic restraint stress (CRS) in mice. Male mice were subjected to a CRS protocol for a period of four weeks to induce stress. The results showed that the ML extract (100 and 500 mg/kg/perorally administered for four weeks) significantly decreased corticosterone levels and increased neurotransmitters levels in stressed mice. Apoptosis by CRS exposure was induced by Bcl-2 and Bax expression regulation and was suppressed by reducing caspase-3 and poly (ADP-ribose) polymerase expression after treatment with the ML extract. Our results confirmed that apoptosis was regulated by increased expression of brain-derived neurotrophic factor (BDNF). Additionally, cytokine levels were regulated by the ML extract. In conclusion, our results showed that the ML extract relieved stress effects by regulating hormones and neurotransmitters in CRS mice, BDNF expression, and apoptosis in the brain. Thus, it can be suggested that the studied ML extract is an agonist that can help relieve stress and depression.

scholarly journals Links between gut dysbiosis and neurotransmitter disturbance in chronic restraint stress-induced depressive behaviours: the role of inflammation

2021 ◽  
Author(s):  
Hai-long Yang ◽  
Meng-Meng Li ◽  
Man-Fei Zhou ◽  
Huai-Sha Xu ◽  
Fei Huan ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Restraint Stress ◽  
Forced Swim Test ◽  
Preference Test ◽  
16S Rrna Gene Sequencing ◽  
Rrna Gene ◽  
Chronic Restraint Stress ◽  
Bdnf Expression ◽  
Behavioural Tests ◽  
Neurotransmitter Metabolism

Abstract Accumulating evidence has shown that inflammation, the gut microbiota and neurotransmitters are closely associated with the pathophysiology of depression. However, the links between the gut microbiota and neurotransmitter metabolism remain poorly understood. The present study aimed to investigate the neuroinflammatory reactions in chronic restraint stress (CRS)-induced depression and to delineate the potential links between the gut microbiota and neurotransmitter metabolism. C57BL/6 mice were subjected to chronic restraint stress for 5 weeks, followed by behavioural tests (the sucrose preference test, forced swim test, open field test and elevated plus maze) and analysis. The results showed that CRS significantly increased IL-1β, IL-2, IL-6 and TNFα levels and decreased BDNF expression, accompanied by the activation of IκBα-p-NF-κB signalling in the mouse hippocampus. In addition, the neurotransmitter metabolomics results showed that CRS resulted in decreased levels of plasma 5-HT, DA, and NE and their corresponding metabolites, and gut microbiota fecal metabolites with the 16S rRNA gene sequencing indicated that CRS caused marked microbiota dysbiosis in mice, with a significant increase in Helicobacter, Lactobacillus, and Oscillibacter and a decrease in Parabacteroides, Ruminococcus, and Prevotella. Notably, CRS-induced depressive behaviours and the disturbance of neurotransmitter metabolism and microbiota dysbiosis can be substantially restored by dexamethasone (DXMS) administration. Furthermore, a Pearson heatmap focusing on correlations between the microbiota, behaviours and neurotransmitters showed that Helicobacter, Lactobacillus, and Oscillibacter were positively correlated with depressive behaviours but were negatively correlated with neurotransmitter metabolism, and Parabacteroides and Ruminococcus were negatively correlated with depressive behaviours but were positively correlated with neurotransmitter metabolism. Taken together, the results suggest that inflammation is involved in microbiota dysbiosis and the disturbance of neurotransmitter metabolism in CRS-induced depressive changes, and the delineation of the potential links between the microbiota and neurotransmitter metabolism will provide novel strategies for depression treatment.

scholarly journals The ROCK Inhibitor Fasudil Prevents Chronic Restraint Stress-Induced Depressive-Like Behaviors and Dendritic Spine Loss in Rat Hippocampus

2016 ◽  
pp. pyw108 ◽  
Author(s):  
Gonzalo García-Rojo ◽  
Cristóbal Fresno ◽  
Natalia Vilches ◽  
Gabriela Díaz-Véliz ◽  
Sergio Mora ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Restraint Stress ◽  
Rat Hippocampus ◽  
Chronic Restraint Stress ◽  
Rock Inhibitor

scholarly journals Effects of escitalopram and paroxetine on mTORC1 signaling in the rat hippocampus under chronic restraint stress

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Mi Kyoung Seo ◽  
Cheol Min Choi ◽  
Roger S. McIntyre ◽  
Hye Yeon Cho ◽  
Chan Hong Lee ◽  
...  
Keyword(s):  
Restraint Stress ◽  
Rat Hippocampus ◽  
Chronic Restraint Stress ◽  
Mtorc1 Signaling

scholarly journals Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: Reversal by tianeptine

2004 ◽  
Vol 101 (7) ◽  
pp. 2179-2184 ◽  
Author(s):  
Lawrence P. Reagan ◽  
Daniel R. Rosell ◽  
Gwendolyn E. Wood ◽  
Michael Spedding ◽  
Carmen Muñoz ◽  
...  
Keyword(s):  
Protein Expression ◽  
Restraint Stress ◽  
Rat Hippocampus ◽  
Chronic Restraint Stress ◽  
Mrna And Protein Expression

scholarly journals Effects of treadmill exercise on cell proliferation and BDNF expression in the rat hippocampus after traumatic brain injury

2008 ◽  
Vol 17 (3) ◽  
pp. 363-372 ◽  
Author(s):  
Lee Hee Hyuk ◽  
Chang-Ju Kim ◽  
Jin hwan Yoon ◽  
김성은 ◽  
JongOh Kim ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Cell Proliferation ◽  
Brain Injury ◽  
Treadmill Exercise ◽  
Rat Hippocampus ◽  
Bdnf Expression
Sign in / Sign up

Export Citation Format

Share Document